Wednesday, February 5, 2025 2/5/2025

Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU)

Award Number: UM1AI069399
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU) SF 424 (R&R) Other Project Information – Project Summary The Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU), current NIAID CRMS site 60338, is a collaboration between the Chiang Mai University-Research Institute for Health Sciences (CMU- RIHES) in Chiang Mai, Thailand, and the Thai Red Cross AIDS Research Centre (TRC-ARC) in Bangkok, Thailand. The specific aims of this application are 1) to renew the THAI CTU as a Clinical Trials Unit to provide scientific, administrative expertise, and infrastructure to conduct clinical studies developed by the four NIH HIV/AIDS Clinical Trials Networks: HIV/AIDS Adult Therapeutics, HIV/AIDS Maternal, Adolescent and Pediatric Therapeutics, HIV Prevention, and HIV Vaccines; and 2) to participate in the development of clinical trials and provide four Clinical Research Sites (CRS) to conduct clinical trials proposed by the four Networks. This CTU renewal involves a change of THAI CTU Principal Investigators from "Suwat Chariyalertsak and Kiat Ruxrungtham" to “Khuanchai Supparatpinyo and Kiat Ruxrungtham". The THAI CTU and its four CRSs will contribute scientifically to the Networks and recruit HIV+ and HIV- participants to clinical studies according to HIV/AIDS research priorities: 1) HIV/AIDS adult therapeutics: 1) interventions to reduce HIV reservoirs; 2) novel and durable interventions targeting HIV treatment; 3) treatment and prevention of drug-sensitive and drug-resistant tuberculosis; 4) treatment and prevention of HIV-related, non-infectious co-morbidities; and 5) studied strategies to cure hepatitis B virus infection in people with and without HIV. High national incidence of viral hepatitis and endemicity of carriage facilitates research on HBV and HCV infections, particularly for cure of hepatitis B. 2) HIV/AIDS maternal, adolescent and pediatric therapeutics: 1) optimization of antiretroviral treatment for these populations; 2) interventions for ART-free remission; 3) treatment and prevention of tuberculosis; 4) treatment and prevention of HIV-related co-morbidities; and 5) treatment and prevention of co-infections. 3) HIV prevention: 1) evaluation of long-acting antiretroviral agents and delivery systems for pre- exposure prophylaxis; 2) evaluation of multipurpose prevention technologies for HIV, pregnancy, sexually transmitted infections, and opioid dependence; 3) evaluation of broadly neutralizing antibodies for pre-exposure prophylaxis; and 4) integrated strategies for HIV prevention. 4) HIV vaccines: 1) evaluation of passive immunization to reduce HIV acquisition in adults; 2) investigation of vaccination of infants; 3) evaluation of immunological, microbiological, and diagnostic technologies for TB vaccination; and 4) research on epidemiological, behavioral, and social sciences for optimization of outcomes of HIV vaccination.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $892,978 )
2025	2025	CHIANG MAI UNIVERSITY RESEARCH INSTITUTE FOR HEALTH SCIENCES	110 INTAVAROROS ROAD	CHIANG MAI				THA	Allergy and Infectious Diseases Research	000	19	11/27/2024	NON-COMPETING CONTINUATION	$892,978
														Subtotal = $892,978

Issue Date FY: 2024 ( Subtotal = $1,956,974 )
2024	2024	CHIANG MAI UNIVERSITY RESEARCH INSTITUTE FOR HEALTH SCIENCES	110 INTAVAROROS ROAD	CHIANG MAI				THA	Allergy and Infectious Diseases Research	001	18	6/26/2024	NON-COMPETING CONTINUATION	$934,570
2024	2024	CHIANG MAI UNIVERSITY RESEARCH INSTITUTE FOR HEALTH SCIENCES	110 INTAVAROROS ROAD	CHIANG MAI				THA	Allergy and Infectious Diseases Research	002	18	7/18/2024	SUPPLEMENT FOR EXPANSION	$87,834
2024	2024	CHIANG MAI UNIVERSITY RESEARCH INSTITUTE FOR HEALTH SCIENCES	110 INTAVAROROS ROAD	CHIANG MAI				THA	Allergy and Infectious Diseases Research	000	18	11/16/2023	NON-COMPETING CONTINUATION	$934,570
														Subtotal = $1,956,974

Issue Date FY: 2023 ( Subtotal = $2,101,022 )
2023	2023	CHIANG MAI UNIVERSITY RESEARCH INSTITUTE FOR HEALTH SCIENCES	110 INTAVAROROS ROAD	CHIANG MAI				THA	Allergy and Infectious Diseases Research	001	17	5/25/2023	NON-COMPETING CONTINUATION	$1,132,089
2023	2023	CHIANG MAI UNIVERSITY RESEARCH INSTITUTE FOR HEALTH SCIENCES	110 INTAVAROROS ROAD	MUANG				THA	Allergy and Infectious Diseases Research	000	17	11/16/2022	NON-COMPETING CONTINUATION	$968,933
														Subtotal = $2,101,022

Issue Date FY: 2022 ( Subtotal = $2,102,686 )
2022	2022	CHIANG MAI UNIVERSITY RESEARCH INSTITUTE FOR HEALTH SCIENCES	110 INTAVAROROS ROAD	MUANG				THA	Allergy and Infectious Diseases Research	001	16	6/14/2022	NON-COMPETING CONTINUATION	$820,047
2022	2022	CHIANG MAI UNIVERSITY RESEARCH INSTITUTE FOR HEALTH SCIENCES	110 INTAVAROROS ROAD	MUANG	CHIANG MAI			THA	Allergy and Infectious Diseases Research	000	16	11/12/2021	NON-COMPETING CONTINUATION	$1,282,637
2022	2020	CHIANG MAI UNIVERSITY RESEARCH INSTITUTE FOR HEALTH SCIENCES	110 INTAVAROROS ROAD	MUANG				THA	Allergy and Infectious Diseases Research	002	14	9/26/2022	NON-COMPETING CONTINUATION	$2
														Subtotal = $2,102,686

Issue Date FY: 2021 ( Subtotal = $2,124,233 )
2021	2021	CHIANG MAI UNIVERSITY RESEARCH INSTITUTE FOR HEALTH SCIENCES	110 INTAVAROROS ROAD	MUANG	CHIANG MAI			THA	Allergy and Infectious Diseases Research	002	15	5/27/2021	COMPETING CONTINUATION	$2
2021	2021	CHIANG MAI UNIVERSITY - RESEARCH INSTITUTE FOR HEALTH SCIENCES	PO BOX 80 CMU, 110 INTAVAROROS ROAD	MUANG	CHIANG MAI			THA	Allergy and Infectious Diseases Research	000	15	11/27/2020	COMPETING CONTINUATION	$1,062,117
2021	2021	CHIANG MAI UNIVERSITY RESEARCH INSTITUTE FOR HEALTH SCIENCES	110 INTAVAROROS ROAD	MUANG	CHIANG MAI			THA	Allergy and Infectious Diseases Research	003	15	6/3/2021	COMPETING CONTINUATION	$1,062,116
2021	2020	CHIANG MAI UNIVERSITY RESEARCH INSTITUTE FOR HEALTH SCIENCES	110 INTAVAROROS ROAD	MUANG	CHIANG MAI			THA	Allergy and Infectious Diseases Research	001	14	5/27/2021	NON-COMPETING CONTINUATION	-$2
														Subtotal = $2,124,233

Issue Date FY: 2020 ( Subtotal = $2,034,744 )
2020	2020	CHIANG MAI UNIVERSITY - RESEARCH INSTITUTE FOR HEALTH SCIENCES	PO BOX 80 CMU, 110 INTAVAROROS ROAD	MUANG	CHIANG MAI	50202		THA	Allergy and Infectious Diseases Research	001	14	6/4/2020	NON-COMPETING CONTINUATION	$1,017,372
2020	2020	CHIANG MAI UNIVERSITY - RESEARCH INSTITUTE FOR HEALTH SCIENCES	PO BOX 80 CMU, 110 INTAVAROROS ROAD	MUANG	CHIANG MAI	50202		THA	Allergy and Infectious Diseases Research	000	14	11/25/2019	NON-COMPETING CONTINUATION	$1,017,372
														Subtotal = $2,034,744

Issue Date FY: 2019 ( Subtotal = $2,180,389 )
2019	2019	CHIANG MAI UNIVERSITY - RESEARCH INSTITUTE FOR HEALTH SCIENCES	PO BOX 80 CMU, 110 INTAVAROROS ROAD	MUANG	CHIANG MAI	50202		THA	Allergy and Infectious Diseases Research	001	13	5/17/2019	NON-COMPETING CONTINUATION	$1,090,194
2019	2019	CHIANG MAI UNIVERSITY - RESEARCH INSTITUTE FOR HEALTH SCIENCES	PO BOX 80 CMU, 110 INTAVAROROS ROAD	MUANG	CHIANG MAI	50202		THA	Allergy and Infectious Diseases Research	000	13	11/16/2018	NON-COMPETING CONTINUATION	$1,090,195
														Subtotal = $2,180,389

Issue Date FY: 2018 ( Subtotal = $1,090,498 )
2018	2018	CHIANG MAI UNIVERSITY - RESEARCH INSTITUTE FOR HEALTH SCIENCES	PO BOX 80 CMU, 110 INTAVAROROS ROAD	MUANG	CHIANG MAI	50202		THA	Allergy and Infectious Diseases Research	001	12	2/28/2018	NON-COMPETING CONTINUATION	$171,778
2018	2018	CHIANG MAI UNIVERSITY - RESEARCH INSTITUTE FOR HEALTH SCIENCES	PO BOX 80 CMU, 110 INTAVAROROS ROAD	MUANG	CHIANG MAI	50202		THA	Allergy and Infectious Diseases Research	003	12	8/10/2018	NON-COMPETING CONTINUATION	$59,828
2018	2018	CHIANG MAI UNIVERSITY - RESEARCH INSTITUTE FOR HEALTH SCIENCES	PO BOX 80 CMU, 110 INTAVAROROS ROAD	MUANG	CHIANG MAI	50202		THA	Allergy and Infectious Diseases Research	000	12	11/29/2017	NON-COMPETING CONTINUATION	$343,557
2018	2018	CHIANG MAI UNIVERSITY - RESEARCH INSTITUTE FOR HEALTH SCIENCES	PO BOX 80 CMU, 110 INTAVAROROS ROAD	MUANG	CHIANG MAI	50202		THA	Allergy and Infectious Diseases Research	002	12	5/18/2018	NON-COMPETING CONTINUATION	$515,335
														Subtotal = $1,090,498

Issue Date FY: 2017 ( Subtotal = $1,026,858 )
2017	2017	CHIANG MAI UNIVERSITY - RESEARCH INSTITUTE FOR HEALTH SCIENCES	PO BOX 80 CMU, 110 INTAVAROROS ROAD	MUANG	CHIANG MAI	50202		THA	Allergy and Infectious Diseases Research	000	11	11/9/2016	NON-COMPETING CONTINUATION	$1,026,858
														Subtotal = $1,026,858

Issue Date FY: 2016 ( Subtotal = $1,209,654 )
2016	2016	RESEARCH INSTITUTE FOR HEALTH SCIENCES	POST OFFICE BOX 80 CMU	CHIANG MAI				THA	Allergy and Infectious Diseases Research	000	10	11/17/2015	NON-COMPETING CONTINUATION	$1,146,054
2016	2016	RESEARCH INSTITUTE FOR HEALTH SCIENCES	POST OFFICE BOX 80 CMU	CHIANG MAI				THA	Allergy and Infectious Diseases Research	001	10	8/4/2016	NON-COMPETING CONTINUATION	$63,600
														Subtotal = $1,209,654

Issue Date FY: 2015 ( Subtotal = $1,080,500 )
2015	2015	RESEARCH INSTITUTE FOR HEALTH SCIENCES	POST OFFICE BOX 80 CMU	CHIANG MAI				THA	Allergy and Infectious Diseases Research	000	9	10/31/2014	NON-COMPETING CONTINUATION	$1,080,500
														Subtotal = $1,080,500

Issue Date FY: 2014 ( Subtotal = $1,571,102 )
2014	2014	RESEARCH INSTITUTE FOR HEALTH SCIENCES	POST OFFICE BOX 80 CMU	CHIANG MAI				THA	Allergy and Infectious Diseases Research	004	8	8/7/2014	COMPETING CONTINUATION	$28,756
2014	2014	RESEARCH INSTITUTE FOR HEALTH SCIENCES	POST OFFICE BOX 80 CMU	CHIANG MAI				THA	Allergy and Infectious Diseases Research	003	8	2/13/2014	COMPETING CONTINUATION	$162,229
2014	2014	RESEARCH INSTITUTE FOR HEALTH SCIENCES	POST OFFICE BOX 80 CMU	CHIANG MAI				THA	Allergy and Infectious Diseases Research	002	8	12/20/2013	COMPETING CONTINUATION	$399,406
2014	2014	RESEARCH INSTITUTE FOR HEALTH SCIENCES	POST OFFICE BOX 80 CMU	CHIANG MAI				THA	Allergy and Infectious Diseases Research	001	8	12/10/2013	COMPETING CONTINUATION	$980,711
2014	2013	RESEARCH INSTITUTE FOR HEALTH SCIENCES	POST OFFICE BOX 80 CMU	CHIANG MAI				THA	Allergy and Infectious Diseases Research	000	7	12/9/2013	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $1,571,102

Issue Date FY: 2013 ( Subtotal = $1,561,607 )
2013	2013	RESEARCH INSTITUTE FOR HEALTH SCIENCES	POST OFFICE BOX 80 CMU	CHIANG MAI				THA	Allergy and Infectious Diseases Research	003	7	12/9/2013	EXTENSION WITH OR WITHOUT FUNDS	$0
2013	2013	RESEARCH INSTITUTE FOR HEALTH SCIENCES	Research Institute for Health Scien	CHIANG MAI				THA	Allergy and Infectious Diseases Research	002	7	6/14/2013	EXTENSION WITH OR WITHOUT FUNDS	$156,164
2013	2013	RESEARCH INSTITUTE FOR HEALTH SCIENCES	Research Institute for Health Scien	CHIANG MAI				THA	Allergy and Infectious Diseases Research	001	7	1/24/2013	EXTENSION WITH OR WITHOUT FUNDS	$1,405,443
2013	2012	RESEARCH INSTITUTE FOR HEALTH SCIENCES	POST OFFICE BOX 80 CMU	CHIANG MAI				THA	Allergy and Infectious Diseases Research	000	6	10/16/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,561,607

Issue Date FY: 2012 ( Subtotal = $1,307,793 ) (Continued on the next page)
2012	2012	RESEARCH INSTITUTE FOR HEALTH SCIENCES	POST OFFICE BOX 80 CMU	CHIANG MAI				THA	Allergy and Infectious Diseases Research	003	6	10/16/2012	NON-COMPETING CONTINUATION	$0
2012	2012	RESEARCH INSTITUTE FOR HEALTH SCIENCES	Research Institute for Health Scien	CHIANG MAI				THA	Allergy and Infectious Diseases Research	002	6	7/18/2012	NON-COMPETING CONTINUATION	$126,024
Grand Total All Awards = $22,241,038

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Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU)

Award Number: UM1AI069399

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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