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University of Wisconsin Institute for Clinical and Translational Research

Award Number: UL1TR002373
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SOCIAL SERVICES
PERIOD OF PERFORMANCE START DATE: 09/21/2017
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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University of Wisconsin Institute for Clinical and Translational Research - Contact PD/PI: Brasier, Allan OVERALL ABSTRACT. This application is for renewal for the Clinical and Translational Science Award (CTSA) at the University of Wisconsin-Madison (UW) Institute for Clinical and Translational Research (ICTR). Through meaningful collaborations with partnering schools and our “spoke” organization, Marshfield Clinic Research Institute, we expand support and innovation to accelerate clinical and translational research (CTR) across our Hub. Over the past funding period, our KL2 scholars have successfully competed for $131M in extramural funding. Our evidence-based CTR mentorship trained 501 master facilitators in 51 CTSAs. We engaged regional networks in 90% of the counties in Wisconsin. Recently, ICTR led multiple impactful mid- course corrections enabling our students, staff, and scientists to effectively address health inequities revealed by the COVID-19 pandemic. Building on user needs assessments, SWOT analyses, and institute-wide strategic planning we developed an Innovation Scorecard that serves as a roadmap to use continuous improvement to address ongoing challenges in conducting efficient, rigorous, and engaged CTR. Our application addresses 5 impactful Aims aligned with objectives in our Innovation Scorecard, each testing explicit hypotheses. These Aims are: 1) Expand skills, efficacy, and resiliency of the CTR workforce to engage effectively in multidisciplinary approaches to CTR. We test an eco-systems approach to promote trainee resiliency, and propose to enhance academic recognition of clinical research, mentorship, and team science. 2) Use bidirectional community engagement and inclusion training for increased involvement of historically underrepresented groups in CTR leading to improved health equity. We will test whether incorporating innovative stakeholder engagement, dissemination and implementation, and team science approaches improve the fidelity and sustainability of interventions in health systems and communities. 3) Employ intentional, systems-level change strategies to break barriers in diversity, equity, and inclusion leading to a campus culture of “inclusive excellence.” We test evidence-based interventions on workforce diversity and ability of translational reams to engage historically underrepresented groups in CTR. 4) Support a sustainable informatics ecosystem to transform data to knowledge, enhance integration of research into health care delivery, and promote rigor and reproducibility in CTR. We will provide and support secure data sharing, interoperable systems, disease-focused registries and well-trained informaticians to advance data-driven CTR. 5) Integrate a “concept-to-closure” support model for clinical research engaging UW Health regional and national networks. We integrate support for CTR within UW Health. We will test whether communities of practice for clinical trialists will enhance our CTR capacity. ICTR’s broad reach, experienced leadership, high-functioning infrastructure, and partnerships will enable us to advance translational science as a rigorous discipline, providing disruptive innovations in CTR. Project Summary/Abstract Page 271 Contact PD/PI: Brasier, Allan OVERALL


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $8,885,006 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	001	8	7/9/2024	NON-COMPETING CONTINUATION	$8,885,006
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	002	8	9/5/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	000	7	12/22/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $8,885,006

Issue Date FY: 2023 ( Subtotal = $8,999,709 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	005	7	7/12/2023	NON-COMPETING CONTINUATION	$8,885,006
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	000	6	12/9/2022	SUPPLEMENT FOR EXPANSION	$114,703
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	006	7	9/26/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	004	6	4/21/2023	COMPETING CONTINUATION	$220,194
2023	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	001	6	3/22/2023	COMPETING CONTINUATION	$0
2023	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	002	5	4/21/2023	NON-COMPETING CONTINUATION	-$216,885
2023	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	003	4	4/21/2023	SUPPLEMENT FOR EXPANSION	-$3,309
														Subtotal = $8,999,709

Issue Date FY: 2022 ( Subtotal = $8,745,944 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	002	6	7/28/2022	COMPETING CONTINUATION	$8,745,944
2022	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	001	5	7/20/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	000	4	3/29/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	003	5	9/13/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $8,745,944

Issue Date FY: 2021 ( Subtotal = $6,431,609 )
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	004	5	6/22/2021	NON-COMPETING CONTINUATION	$6,334,971
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	000	4	12/14/2020	SUPPLEMENT FOR EXPANSION	$96,638
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	002	4	4/17/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	003	4	4/22/2021	NON-COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	001	4	3/15/2021	NON-COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	005	4	6/23/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $6,431,609

Issue Date FY: 2020 ( Subtotal = $6,446,765 )
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Trans-NIH Research Support	001	4	8/19/2020	SUPPLEMENT FOR EXPANSION	$276,463
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	000	4	7/1/2020	NON-COMPETING CONTINUATION	$6,170,302
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	002	4	9/14/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $6,446,765

Issue Date FY: 2019 ( Subtotal = $6,171,746 )
2019	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	001	3	7/15/2019	NON-COMPETING CONTINUATION	$6,171,746
2019	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	000	2	4/17/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $6,171,746

Issue Date FY: 2018 ( Subtotal = $6,178,941 )
2018	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	000	2	8/1/2018	NON-COMPETING CONTINUATION	$6,178,941
														Subtotal = $6,178,941

Issue Date FY: 2017 ( Subtotal = $6,237,009 )
2017	2017	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	National Center for Advancing Translational Sciences	000	1	9/21/2017	NEW	$6,237,009
														Subtotal = $6,237,009

Grand Total All Awards = $58,096,729

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University of Wisconsin Institute for Clinical and Translational Research

Award Number: UL1TR002373

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SOCIAL SERVICES

PERIOD OF PERFORMANCE START DATE: 09/21/2017

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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