Thursday, November 21, 2024 11/21/2024

Clinical and Translational Science Award

Award Number: UL1TR001873
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SOCIAL SERVICES

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Project Summary/Abstract In response to NOT-OD-24-031 Notice of Special Interest (NOSI, we propose to conduct research on bioethical issues in the return of individual research results (IRR) that would support the development of an evidence base to inform future policy directions. We intend to capitalize on a unique opportunity to assess the views of a large number of research participants at Columbia University Irving Medical Center (CUIMC) who constitute an unusual sample in two critical ways: 1) they are highly diverse; and 2) all will already have received IRR as part of the NHGRI-sponsored eMERGE-IV study. We will use this sample to explore the experiences and preferences of people with lived experience of receiving their own research results. A consensus has evolved that IRR should be offered for return to research participants, as summarized in a 2018 report by the National Academies of Science, Engineering and Medicine. Most of the extant studies address the return of genetic/genomic results and show a strong desire to receive individual results and largely benign responses to those results. Although outside the realm of genetics the body of literature on return of research results is much smaller (e.g., for receipt of disease-associated biomarkers), similar albeit somewhat more variable findings have been demonstrated. Participants’ consistent preferences to receive individual research results have led to calls to focus future research on the major outstanding questions involved in return of results: which results should be offered for return, when should results be returned, how should results be returned, and what participant characteristics may help to identify and satisfy participant preferences? Ascertaining experienced participants’ views on these issues is the key focus of this proposal, expanding the focus to a broader range of research results (e.g., biomedical markers of health, behavior, and environmental exposures) and analyzed through four Specific Aims exploring: 1) How do research participants’ preferences for return of individual research results vary by type of result? 2) How are participants’ preferences affected by their demographic characteristics, including race/ethnicity, education, income, and health insurance status? 3) To what extent are participants’ preferences for return of individual research results affected by their perceptions of the potential benefits and risks of their receipt? 4) What are participants’ preferences for the means of IRR and the information and support that should accompany them? Our results will inform future studies, policies and practices for the return of study results at Columbia, within the CTSA consortium, and across the larger biomedical community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	001	9	10/22/2024	SUPPLEMENT FOR EXPANSION	$0
2025	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	000	9	10/22/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $10,449,750 )
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	001	9	6/12/2024	NON-COMPETING CONTINUATION	$10,288,366
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	002	9	8/7/2024	SUPPLEMENT FOR EXPANSION	$161,384
2024	2023	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	000	8	2/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $10,449,750

Issue Date FY: 2023 ( Subtotal = $10,583,633 )
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	005	8	7/26/2023	NON-COMPETING CONTINUATION	$10,299,800
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	007	8	9/12/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	006	8	8/21/2023	SUPPLEMENT FOR EXPANSION	$283,833
2023	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	004	7	6/6/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	003	7	5/23/2023	NON-COMPETING CONTINUATION	$0
2023	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	000	7	1/28/2023	NON-COMPETING CONTINUATION	$0
2023	2021	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	002	6	5/1/2023	COMPETING CONTINUATION	$9,735
2023	2020	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	001	5	2/2/2023	NON-COMPETING CONTINUATION	-$9,735
														Subtotal = $10,583,633

Issue Date FY: 2022 ( Subtotal = $10,262,967 )
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	004	7	8/5/2022	SUPPLEMENT FOR EXPANSION	$100,172
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	003	7	7/30/2022	NON-COMPETING CONTINUATION	$10,162,796
2022	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	002	6	11/11/2021	COMPETING CONTINUATION	$1,198,398
2022	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	000	5	11/7/2021	SUPPLEMENT FOR EXPANSION	-$1
2022	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	001	5	11/11/2021	NON-COMPETING CONTINUATION	-$1,198,398
														Subtotal = $10,262,967

Issue Date FY: 2021 ( Subtotal = $10,120,986 )
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	001	6	6/28/2021	COMPETING CONTINUATION	$10,120,986
2021	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	000	5	11/24/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $10,120,986

Issue Date FY: 2020 ( Subtotal = $9,526,151 )
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	002	5	9/12/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	000	5	5/26/2020	NON-COMPETING CONTINUATION	$9,364,151
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	001	5	7/10/2020	SUPPLEMENT FOR EXPANSION	$162,000
														Subtotal = $9,526,151

Issue Date FY: 2019 ( Subtotal = $10,015,359 )
2019	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	002	4	9/17/2019	SUPPLEMENT FOR EXPANSION	$639,915
2019	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	001	4	5/30/2019	NON-COMPETING CONTINUATION	$9,375,444
2019	2018	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	000	3	11/22/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $10,015,359

Issue Date FY: 2018 ( Subtotal = $9,337,463 )
2018	2018	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	000	3	6/12/2018	NON-COMPETING CONTINUATION	$9,337,463
														Subtotal = $9,337,463

Issue Date FY: 2017 ( Subtotal = $9,340,650 )
2017	2017	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	001	2	9/1/2017	NON-COMPETING CONTINUATION	$934,066
2017	2017	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	National Center for Advancing Translational Sciences	000	2	6/15/2017	NON-COMPETING CONTINUATION	$8,406,584
														Subtotal = $9,340,650

Issue Date FY: 2016 ( Subtotal = $9,345,565 )
2016	2016	COLUMBIA UNIVERSITY, SCHOOL OF ARTS & SCIENCES	106 LOW LIBRARY	NEW YORK-NEW YORK	NY	10027		USA	National Center for Advancing Translational Sciences	000	1	7/1/2016	NEW	$9,345,565
														Subtotal = $9,345,565

Grand Total All Awards = $88,982,524

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Clinical and Translational Science Award

Award Number: UL1TR001873

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SOCIAL SERVICES

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