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Center for Clinical and Translational Science and Training

Award Number: UL1TR001425
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SOCIAL SERVICES
PERIOD OF PERFORMANCE START DATE: 08/14/2015
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Center for Clinical and Translational Science and Training - Contact PD/PI: Heubi, James E OVERALL ABSTRACT The Center for Clinical and Translational Science and Training (CCTST) was established at the University of Cincinnati (UC) in 2005 and awarded an institutional Clinical and Translational Science Award (CTSA) in 2009. Since that time, basic science research, genomics, technology, and drug development have made remarkable progress, warranting new solutions for translating research to practice. Concurrent with these discoveries, the CCTST has created innovative solutions for our program functions, including biomedical informatics, biostatistics and study design, regulatory and ethics, community engagement and team science, recruitment and support for clinical trials, patient care interactions, pilot grants, and translational workforce development. With the competitive renewal application and the current revision and creation of CCTST 3.0, we will continue to utilize the guiding principles of learning health systems to develop stronger bidirectional relationships with our community and expeditiously bring discoveries to application. Indeed, we intend to capture this tremendous opportunity to better align the clinical/operational mission of the health system with the research mission of the University and its affiliates. The overarching goal of the CCTST is to maximize the impact of clinical and translational research to improve individual and population health locally and nationally, through 1) engaging stakeholders to collaboratively translate research into improved health care practice and community wellness across the lifespan; 2) developing a diverse, multidisciplinary workforce to conduct innovative, team-based, community-engaged translational research and to disseminate and implement findings that will improve health outcomes and reduce disparities; and 3) optimizing the use of biomedical data across the translational research continuum using innovative data science methods to advance discovery, dissemination, and implementation. For each of the programs and optional functions, these aims serve as the basis for planned innovative activities and to facilitate cross-core integration. We specifically target learning health systems as an optional module for this application because of the expertise available at Cincinnati Children's Hospital Medical Center that can be leveraged across the CCTST and its health care affiliates. In fulfilling these aims, CCTST 3.0 will catalyze the translation of discoveries into improved health outcomes locally and nationally. Page 307 Project Summary/Abstract Contact PD/PI: Heubi, James E NARRATIVE The CTSA consortium has matured to the point that 57 sites are working together to advance science with the goal to improve the health of the nation. The University of Cincinnati Center for Clinical and Translational Science and Training has become a portal of entry for clinical and translational investigators to obtain support for the completion of their studies across the spectrum of translational science, from the bench to population health. With this revised renewal application, we will develop additional innovative methods to produce high quality research, share these discoveries, collaborate with other CTSA hubs, and have a measurable impact on the health of our community using the principles of a learning health system. Page 308


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	001	9	12/9/2024	NON-COMPETING CONTINUATION	$0
2025	2024	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	000	9	11/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $4,520,152 )
2024	2024	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	001	9	4/11/2024	NON-COMPETING CONTINUATION	$4,520,152
2024	2023	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	000	8	1/19/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,520,152

Issue Date FY: 2023 ( Subtotal = $4,520,152 )
2023	2023	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	001	8	4/25/2023	NON-COMPETING CONTINUATION	$4,520,152
2023	2022	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	000	7	10/27/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,520,152

Issue Date FY: 2022 ( Subtotal = $4,520,152 )
2022	2022	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	007	7	9/22/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	006	7	4/25/2022	NON-COMPETING CONTINUATION	$4,520,152
2022	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	004	6	3/1/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	003	6	1/21/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	002	6	12/7/2021	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	005	6	4/20/2022	NON-COMPETING CONTINUATION	$0
2022	2020	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	001	5	11/1/2021	COMPETING CONTINUATION	$430,786
2022	2018	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	000	4	11/1/2021	NON-COMPETING CONTINUATION	-$430,786
														Subtotal = $4,520,152

Issue Date FY: 2021 ( Subtotal = $4,617,480 )
2021	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	002	6	5/24/2021	NON-COMPETING CONTINUATION	$4,540,391
2021	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	005	6	6/23/2021	SUPPLEMENT FOR EXPANSION	$77,089
2021	2020	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	004	5	6/9/2021	COMPETING CONTINUATION	-$758,916
2021	2020	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	001	5	4/5/2021	COMPETING CONTINUATION	$758,916
2021	2018	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	000	4	4/5/2021	NON-COMPETING CONTINUATION	-$758,916
2021	2018	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	003	4	6/9/2021	NON-COMPETING CONTINUATION	$758,916
														Subtotal = $4,617,480

Issue Date FY: 2020 ( Subtotal = $4,542,253 )
2020	2020	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	003	5	9/15/2020	COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	002	5	8/28/2020	SUPPLEMENT FOR EXPANSION	$109,875
2020	2020	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	000	5	3/27/2020	COMPETING CONTINUATION	$4,432,378
2020	2020	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	001	5	5/13/2020	COMPETING CONTINUATION	$0
														Subtotal = $4,542,253

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	000	4	1/26/2019	NON-COMPETING CONTINUATION	$0
2019	2018	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	001	4	9/5/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $3,459,900 )
2018	2018	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	000	4	4/26/2018	NON-COMPETING CONTINUATION	$3,459,900
2018	2018	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	001	4	9/24/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,459,900

Issue Date FY: 2017 ( Subtotal = $3,720,928 )
2017	2017	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	001	3	8/30/2017	NON-COMPETING CONTINUATION	$342,179
2017	2017	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Trans-NIH Research Support	002	3	9/20/2017	SUPPLEMENT FOR EXPANSION	$301,546
2017	2017	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	National Center for Advancing Translational Sciences	000	3	6/1/2017	NON-COMPETING CONTINUATION	$3,077,203
														Subtotal = $3,720,928

Issue Date FY: 2016 ( Subtotal = $4,434,523 )
2016	2016	UNIVERSITY OF CINCINNATI	PO BOX 210225	CINCINNATI	OH	45221	HAMILTON	USA	National Center for Advancing Translational Sciences	000	2	4/13/2016	NON-COMPETING CONTINUATION	$3,418,842
2016	2016	UNIVERSITY OF CINCINNATI	PO BOX 210225	CINCINNATI	OH	45221	HAMILTON	USA	National Center for Advancing Translational Sciences	001	2	7/8/2016	SUPPLEMENT FOR EXPANSION	$1,015,681
														Subtotal = $4,434,523

Issue Date FY: 2015 ( Subtotal = $3,187,599 )
2015	2015	UNIVERSITY OF CINCINNATI	PO BOX 210225	CINCINNATI	OH	45221	HAMILTON	USA	National Center for Advancing Translational Sciences	000	1	8/14/2015	NEW	$3,187,599
														Subtotal = $3,187,599

Grand Total All Awards = $37,523,139

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Center for Clinical and Translational Science and Training

Award Number: UL1TR001425

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SOCIAL SERVICES

PERIOD OF PERFORMANCE START DATE: 08/14/2015

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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