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Wake Forest Clinical and Translational Science Award

Award Number: UL1TR001420
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SOCIAL SERVICES
PERIOD OF PERFORMANCE START DATE: 08/13/2015
PERIOD OF PERFORMANCE END DATE: 08/31/2024

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Wake Forest Clinical and Translational Science Award - Contact PD/PI: MCCLAIN, DONALD A. Summary: Overall When the Wake Forest (WF) Clinical and Translational Science Institute (CTSI) joined the CTSA consortium in August 2015, our goal was to use our resources to catalyze WF’s transformation into an exemplary Learning Health System in which “science, informatics, incentives, and culture are aligned for continuous improvement and innovation, with best practices seamlessly embedded in the delivery process and new knowledge captured as an integral by-product of the delivery experience.” We seek to extend this framework by integrating traditional academic goals of T0 – T4 discovery, translation, and scholarship to form a new vision—the Academic Learning Health System (aLHS). In our initial 3 years of funding, we have progressed towards our goal, establishing an integrated research governance model, with the CTSI at its core, to realize efficiencies and address roadblocks that hamper translational progress. We established Translational Catalysts to link the academic and clinical enterprises and designed training programs to develop the skills our workforce needs to make the aLHS a reality. We developed foundational informatics infrastructures essential to learning and growing, engaged communities and stakeholders to integrate diverse perspectives into the fabric of our aLHS, and created a milieu for nurturing innovative translational methods. We became a valued member of the CTSA national network, actively collaborating with 20 CTSA hubs, and shared our world-class nonhuman primate models with the consortium. With these successes, we turn to the next 5 years with strong assets in leadership, structure, scholarship, and culture that uniquely position us to realize the aLHS ideal. We will fully integrate our new Translational Catalysts – biomedical informatics, implementation science, precision medicine, healthcare innovation, and clinical trials – and use them, along with incentives for academic engagement, to mobilize our growing clinical network. We will develop, implement, and broadly disseminate improved methods and processes that will increase the efficiency, safety, and reproducibility of preclinical and clinical science. We will partner with our community to integrate special populations, and support health research across the lifespan. We will train our workforce for new roles, especially in team environments, with new training programs (e.g., TL1 aLHS Scholars Program, the Learning TREE online educational platform for individualized learning, Research-in-Action) and broaden our highly successful KL2 training for early-career faculty. We will serve as a hub for biomedical informatics, accelerating progress by enhancing existing resources, promoting collaboration and data sharing, and building new capacity. We will remain committed to inclusiveness, mutual respect, and multiple perspectives to act as a catalyst for change and healthy equity. We will further extend the reach of the aLHS into the communities served by our expanding health system and will broaden our collaborations with other CTSA hubs to share best practices and export the aLHS model – all guided by our ultimate goal of improving the health of our region and nation. Page 243 Project Summary/Abstract Contact PD/PI: MCCLAIN, DONALD A. Narrative: Overall The Wake Forest Clinical and Translational Science Institute seeks to become the model of an integrated Academic Learning Health System in which we develop, implement, offer tailored training tools, and broadly disseminate improved methods and processes to increase the efficiency, safety, and reproducibility of preclinical and clinical science. We will build on our achievements to fully integrate our new Translational Catalysts – biomedical informatics, implementation science, precision medicine, healthcare innovation and clinical trials – and use them to develop and test initiatives, deploying research findings across our growing clinical network. We will remain comm


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$1,496,098 )
2025	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	000	9	2/11/2025	NON-COMPETING CONTINUATION	-$1,496,098
														Subtotal = -$1,496,098

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	003	9	8/29/2024	NON-COMPETING CONTINUATION	$0
2024	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	002	9	4/25/2024	NON-COMPETING CONTINUATION	$0
2024	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	000	9	1/8/2024	NON-COMPETING CONTINUATION	$0
2024	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	001	9	1/22/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $3,927,951 )
2023	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	001	9	7/1/2023	NON-COMPETING CONTINUATION	$3,927,951
2023	2022	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	000	8	6/7/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,927,951

Issue Date FY: 2022 ( Subtotal = $3,891,888 )
2022	2022	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	000	8	7/18/2022	NON-COMPETING CONTINUATION	$3,927,951
2022	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	001	7	9/21/2022	SUPPLEMENT FOR EXPANSION	-$43,271
2022	2018	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	002	4	9/26/2022	NON-COMPETING CONTINUATION	$7,208
														Subtotal = $3,891,888

Issue Date FY: 2021 ( Subtotal = $4,089,025 )
2021	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	001	7	6/29/2021	NON-COMPETING CONTINUATION	$3,927,951
2021	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	000	6	1/20/2021	SUPPLEMENT FOR EXPANSION	$51,533
2021	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	002	7	6/30/2021	SUPPLEMENT FOR EXPANSION	$109,541
														Subtotal = $4,089,025

Issue Date FY: 2020 ( Subtotal = $3,948,176 )
2020	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	003	6	6/26/2020	NON-COMPETING CONTINUATION	$3,824,885
2020	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	004	6	7/6/2020	SUPPLEMENT FOR EXPANSION	$123,291
2020	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	000	5	11/23/2019	COMPETING CONTINUATION	$0
2020	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	002	5	2/7/2020	COMPETING CONTINUATION	$1,274,282
2020	2018	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	001	4	2/7/2020	NON-COMPETING CONTINUATION	-$1,274,282
														Subtotal = $3,948,176

Issue Date FY: 2019 ( Subtotal = $3,824,885 )
2019	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	001	5	6/27/2019	COMPETING CONTINUATION	$3,824,885
2019	2018	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	000	4	6/27/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,824,885

Issue Date FY: 2018 ( Subtotal = $3,388,470 )
2018	2018	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	000	4	4/19/2018	NON-COMPETING CONTINUATION	$3,388,470
														Subtotal = $3,388,470

Issue Date FY: 2017 ( Subtotal = $2,610,385 )
2017	2017	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	002	3	9/19/2017	NON-COMPETING CONTINUATION	-$754,842
2017	2017	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	000	3	4/27/2017	NON-COMPETING CONTINUATION	$3,028,705
2017	2017	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	001	3	9/7/2017	NON-COMPETING CONTINUATION	$336,522
														Subtotal = $2,610,385

Issue Date FY: 2016 ( Subtotal = $3,365,310 )
2016	2016	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	000	2	3/29/2016	NON-COMPETING CONTINUATION	$3,365,310
														Subtotal = $3,365,310

Issue Date FY: 2015 ( Subtotal = $3,232,083 )
2015	2015	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	National Center for Advancing Translational Sciences	000	1	8/13/2015	NEW	$3,232,083
														Subtotal = $3,232,083

Grand Total All Awards = $30,782,074

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Wake Forest Clinical and Translational Science Award

Award Number: UL1TR001420

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SOCIAL SERVICES

PERIOD OF PERFORMANCE START DATE: 08/13/2015

PERIOD OF PERFORMANCE END DATE: 08/31/2024

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