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Organs-on-Chips as a Platform for Studying Effects of Microgravity on Human Physiology: Blood-Brain Barrier-Chip in Health and Disease

Award Number: UH3TR002188
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2017
PERIOD OF PERFORMANCE END DATE: 02/28/2022

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Organs-on-Chips as a Platform for Studying Effects of Microgravity on Human Physiology: Blood-Brain Barrier-Chip in Health and Disease - Abstract In response to the National Institutes of Health (NIH), -Center for the Advancement of Science in Space (CASIS), -Request for Application (RFA), -Targeted Research (TR), -16-019 we propose to apply the Organ- Chip technology of Emulate Inc., to assess the effects of space flight in human organs in vitro. Emulate is a newly founded start-up based on technology developed at the Wyss Institute at Harvard University in Cambridge, Massachusetts. The proposed work focuses on the development of automated hardware for space to enable experiments in human, in vivo relevant microphysiological systems for understanding of the impact of microgravity and other space flight-imposed stressors on human physiology, disease development and response to drugs. The organ we will apply to all proposed studies is the blood-brain barrier (BBB)-Chip, both in normal and inflamed states, which causes a major compromise in the BBB and allows for evaluation of clinically relevant endpoints. In this proposal, we will first validate Emulate’s Organ-Chip technology, and the automated instrumentation to be developed together with implementation partners SpaceTango, in terrestrial experiments simulating the space flight protocols. Next, we will use the platform to conduct two separate organ-chip experiments on the International Space Station (ISS) to understand the effects of this unique environment on BBB physiology. Further, terrestrial experiments will assess the specific contribution of each of the individual, primary cell stressors in space that can be simulated on Earth. Imaging, biochemical, and transcriptomic data from all studies over different time points will be analyzed, compared and provide the inputs for building a model of the system. We believe that our integrative approach will reveal new aspects of the effects of microgravity on the BBB in normal and disease states, and provide insights into drug discovery for this critical organ that maintains homeostasis or propagates a number of serious diseases. Successful implementation of our space compatible hardware and our BBB-Chip findings will provide an in vivo relevant, in vitro platform available to the scientific community for the evaluation of the impact of microgravity in physiology and disease of a number of human organs, and support drug development in novel, clinically relevant ways.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	EMULATE INC	27 DRYDOCK AVE	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	4	12/15/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	EMULATE, INC.	27 DRYDOCK AVE FL 5	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	4	3/1/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	EMULATE, INC.	27 DRYDOCK AVE FL 5	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	3	8/22/2021	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $892,952 )
2020	2020	EMULATE, INC.	27 DRYDOCK AVE FL 5	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	4	3/12/2020	NON-COMPETING CONTINUATION	$892,952
														Subtotal = $892,952

Issue Date FY: 2019 ( Subtotal = $859,237 )
2019	2019	EMULATE, INC.	27 DRYDOCK AVE FL 5	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	3	4/25/2019	EXTENSION WITH OR WITHOUT FUNDS	$859,237
														Subtotal = $859,237

Grand Total All Awards = $1,752,189

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Organs-on-Chips as a Platform for Studying Effects of Microgravity on Human Physiology: Blood-Brain Barrier-Chip in Health and Disease

Award Number: UH3TR002188

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2017

PERIOD OF PERFORMANCE END DATE: 02/28/2022

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