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The Early Growth and Development Study Cohort of the ECHO Program

Award Number: UH3OD023389
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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The Early Growth and Development Study Cohort of the ECHO Program - Project Summary The combined economic and personal effects of children’s neurodevelopmental problems, such as conduct disorder, ADHD, and depression and anxiety symptoms are substantial. At the same time, there is growing evidence that dimensions of positive health can support children in leading meaningful, productive lives. In the current proposal we address knowledge gaps related to the timing of psychosocial environmental exposures and when their effects on child neurodevelopment and positive health emerge, and at what ages children’s risk factors and assets are most potent in affecting developmental trajectories. We also propose to examine the transition to adolescence. Adolescence can be a turning point in child development given rapid changes in the brain, emotional, and social system, yet longitudinal studies from infancy to adolescence with large cohorts of children from diverse backgrounds are sorely lacking. Last, children’s neurodevelopment and positive health are rarely examined in concert, leading to incomplete assessments of children’s mental health at all phases of development. This application seeks to fill some of these knowledge gaps through participation in the Environmental influences on Child Health Outcomes (ECHO) Cohort Study Sites for Pediatric Follow Up Program. In this application, we propose to follow an existing sample of 1,000 children from the Early Growth and Development Study (EGDS) cohort who are enrolled as Level 2 participants in the ECHO Program and have ECHO Cohort Protocol data elements beginning in the prenatal period. EGDS is a nationwide sample of children living with either their adoptive or biological parent(s). Children will be age 7 – 20 years old and assessed annually using the ECHO Cohort Protocol in the proposed study. We have been highly successful in achieving our planned recruitment and enrollment rates, collecting and sharing data with the ECHO Program, and contributing to ECHO-wide science and manuscripts in the current ECHO funding cycle. We will build on our successes and infrastructure to contribute to ECHO’s goals through leading collaborative ECHO Cohort science, with a dual focus on ECHO Cohort Protocol core data elements and on two specialized child outcome areas: Neurodevelopment and Child Positive Health. Through three specific aims, we will: (1) leverage ECHO Cohort Protocol core data elements to examine the immediate and latent impact of early exposures on child health outcomes across different developmental periods in diverse contexts; (2) leverage data from specialized outcomes to test predictors of change in neurodevelopment and positive health in adolescence; and, (3) implement data-driven check points every quarter to assess our retention of existing cohort participants, with an emphasis on diversity and implementation of the protocol with high fidelity. Our overall goal is to work collaboratively with the ECHO Program to advance the understanding of predictors and outcomes of child health in order to inform programs, practices, and policies that will improve the health of children for generations to come.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF OREGON	1776 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	000	10	1/14/2026	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $612,553 )
2025	2025	UNIVERSITY OF OREGON	1776 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	001	10	8/26/2025	EXTENSION WITH OR WITHOUT FUNDS	$210,877
2025	2025	UNIVERSITY OF OREGON	1776 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	000	10	7/7/2025	EXTENSION WITH OR WITHOUT FUNDS	$369,689
2025	2025	UNIVERSITY OF OREGON	1776 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	002	10	8/28/2025	EXTENSION WITH OR WITHOUT FUNDS	$31,987
														Subtotal = $612,553

Issue Date FY: 2024 ( Subtotal = -$464,892 )
2024	2022	UNIVERSITY OF OREGON	1776 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	000	7	4/2/2024	NON-COMPETING CONTINUATION	-$464,892
														Subtotal = -$464,892

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	000	7	5/15/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $2,955,666 )
2022	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	002	7	9/1/2022	NON-COMPETING CONTINUATION	$2,955,666
2022	2021	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	001	6	7/26/2022	NON-COMPETING CONTINUATION	$0
2022	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	000	3	2/12/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $2,955,666

Issue Date FY: 2021 ( Subtotal = $3,023,945 )
2021	2021	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	000	6	8/26/2021	NON-COMPETING CONTINUATION	$2,955,666
2021	2021	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Child Health and Human Development Extramural Research	001	6	9/2/2021	SUPPLEMENT FOR EXPANSION	$68,279
														Subtotal = $3,023,945

Issue Date FY: 2020 ( Subtotal = $3,338,048 )
2020	2020	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	001	5	8/17/2020	NON-COMPETING CONTINUATION	$2,955,666
2020	2020	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	004	5	9/22/2020	SUPPLEMENT FOR EXPANSION	$155,034
2020	2020	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	003	5	8/19/2020	SUPPLEMENT FOR EXPANSION	$155,030
2020	2020	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	002	5	8/18/2020	SUPPLEMENT FOR EXPANSION	$71,705
2020	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	000	3	3/16/2020	EXTENSION WITH OR WITHOUT FUNDS	$613
														Subtotal = $3,338,048

Issue Date FY: 2019 ( Subtotal = $3,713,891 )
2019	2019	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	002	4	8/26/2019	NON-COMPETING CONTINUATION	$2,858,753
2019	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	000	3	2/8/2019	EXTENSION WITH OR WITHOUT FUNDS	$1,117,063
2019	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	001	3	5/20/2019	EXTENSION WITH OR WITHOUT FUNDS	-$261,925
														Subtotal = $3,713,891

Issue Date FY: 2018 ( Subtotal = $2,522,413 )
2018	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Trans-NIH Research Support	000	3	8/29/2018	EXTENSION WITH OR WITHOUT FUNDS	$2,522,413
														Subtotal = $2,522,413

Grand Total All Awards = $15,701,624

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The Early Growth and Development Study Cohort of the ECHO Program

Award Number: UH3OD023389

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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