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Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence

Award Number: UH3OD023365
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence - Beginning in fall, 2016, the UC Davis pediatric cohort, ReCHARGE, was funded with the new Environmental Influences on Child Health Outcomes (ECHO) Consortium that encompassed close to 80 sites. Now in year 7 of ECHO Phase 1, UC Davis has enrolled ~900 children into ECHO from three neurodevelopmental groups of children with: autism spectrum disorder (ASD), developmental delays (DD) without autistic symptoms, and typical development (TD); uploaded over 55,000 data collection forms to the ECHO Cohort Data Platform, and transferred over 8000 biospecimen aliquots to the ECHO Biorepository, including DNA for SNP arrays, urine for analyzing novel chemicals from common but understudied household products, and blood for multiple uses. The UC Davis ECHO team led a number of analysis proposals, authored/coauthored 40 peer-reviewed papers, with another 50 in-progress. The Team also contributed to developing ECHO policies and participated in and led various working groups, such as Neurodevelopment, Chemical Exposures, Epigenetics, as well as Committees on Publications, Policy Implementation and Evaluation, and others. The ECHO-ReCHARGE cohort focuses on the ECHO area of neurodevelopment, which is facilitated by the UC Davis MIND Institute. In ECHO Phase 2, the UC Davis Aim 1 will: examine environmental exposures including air pollution, greenspace, and home product use; as well as family financial hardship and parental mental health or substance use problems, in associations with externalizing and internalizing behaviors, namely, symptoms of ADHD, anxiety and depression at ages 8-20; and potential modification of exposure-outcome associations by early childhood developmental diagnosis (ASD, DD, TD), age, sex and puberty status. Aim 2 will evaluate the environmental exposures listed above along with childhood exposure to PFAS and plasticizers, for associations with longitudinal trajectories of the above behavioral and emotional outcomes, as well as cognitive skills. Aim 3 will implement the final ECHO protocol with high fidelity, maximize retention, and adhere to all ECHO policies, IRB, HIPAA and other regulations. UC Davis will continue to contribute broadly to the ECHO infrastructure; advance the science through analysis and publications; work to retain participants; and actively participate and play leadership roles in this high-profile, unique program to discover underlying risk and resilience factors for childhood health and development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	000	10	6/5/2025	EXTENSION WITH OR WITHOUT FUNDS	$1
														Subtotal = $1

Issue Date FY: 2024 ( Subtotal = -$2,111,216 )
2024	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	000	7	4/9/2024	NON-COMPETING CONTINUATION	-$2,111,216
														Subtotal = -$2,111,216

Issue Date FY: 2022 ( Subtotal = $4,588,668 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	002	7	8/12/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	003	7	8/12/2022	SUPPLEMENT FOR EXPANSION	$66,525
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	001	7	8/11/2022	NON-COMPETING CONTINUATION	$4,522,143
2022	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	000	6	5/5/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,588,668

Issue Date FY: 2021 ( Subtotal = $3,988,668 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	001	6	8/17/2021	NON-COMPETING CONTINUATION	$3,922,143
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	002	6	8/18/2021	SUPPLEMENT FOR EXPANSION	$66,525
2021	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	000	5	5/27/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,988,668

Issue Date FY: 2020 ( Subtotal = $3,912,445 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	000	5	8/14/2020	NON-COMPETING CONTINUATION	$3,912,445
														Subtotal = $3,912,445

Issue Date FY: 2019 ( Subtotal = $5,593,537 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	001	4	9/9/2019	NON-COMPETING CONTINUATION	$4,872,143
2019	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	000	3	2/8/2019	EXTENSION WITH OR WITHOUT FUNDS	$721,394
														Subtotal = $5,593,537

Issue Date FY: 2018 ( Subtotal = $4,522,143 )
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	000	3	8/29/2018	EXTENSION WITH OR WITHOUT FUNDS	$4,522,143
														Subtotal = $4,522,143

Grand Total All Awards = $20,494,246

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Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence

Award Number: UH3OD023365

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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