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ASSESSING THE EVOLVING IMPACT OF EARLY LIFE EXPOSURES ON CHILD PHYSICAL HEALTH AND NEURODEVELOPMENT

Award Number: UH3OD023313
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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ASSESSING THE EVOLVING IMPACT OF EARLY LIFE EXPOSURES ON CHILD PHYSICAL HEALTH AND NEURODEVELOPMENT - How does a healthy child grow? Asked by every parent, the simplicity of this question masks the complex nature of child development and makes light of the range of environmental factors and variables that shape a child’s emerging physical health and neurodevelopment. Beginning at conception and accelerating throughout childhood and adolescence, our unique environmental exposures and social experiences shape our behaviors, impact our health, and influence our developing cognitive skills and abilities. Far from being distinct entities, aspects of physical health and neurodevelopment evolve dynamically together in a bi-directional feedback cycle that promotes healthy or rapidly worsening outcomes. At every stage of this cycle, factors that affect the child (e.g., sleep, chemical exposures), their family (e.g., family sociodemographic characteristics), and their neighborhood (e.g., neighborhood safety, school quality) can improve health or accelerate decline. Over the past two years, the COVID-19 pandemic has ushered in widespread disruptions to almost every aspect of a child and family’s life. Differences in public health responses across the ECHO Cohort offer an important opportunity to understand how these multi-level factors have moderated child physical health and neurodevelopment. Leveraging the ECHO Cohort and taking a team science approach, this proposal aims to understand the dynamic relationships that link child neurodevelopment and two pressing public health challenges: pediatric asthma and obesity; and the influence of specific multi-level moderators (e.g., chemical exposures, child sleep, physical activity). We will examine: 1. How child neurodevelopment and physical health outcomes, specifically asthma, and obesity are shaped by chemical, biological, and social environmental exposures; 2. How physical health and neurodevelopment co-develop and reinforce each other throughout childhood; 3. How lived experiences across the child, family, and neighborhood contexts moderate neurodevelopmental outcomes; and 4. How these relationships have been changed by the COVID-19 pandemic. We will take an intentional approach to include and consider the social, psychosocial, and economic factors and behavioral norms that underlie variations in in neurodevelopment and child physical health outcomes. We will re-enroll our Cohort Study Site (RESONANCE) comprising >1000 well-characterized family-child dyads from a range of sociodemographic backgrounds across Rhode Island. Using novel remote data collection and mobile labs, we will address traditional barriers to research participation while ensuring adherence and high data quality across all core elements and biospecimens. Outcomes from our solutions-oriented research will have a direct and meaningful impact on health interventions and public policy guidance.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1 )
2025	2025	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	000	12	6/11/2025	EXTENSION WITH OR WITHOUT FUNDS	$1
														Subtotal = $1

Issue Date FY: 2024 ( Subtotal = -$1,376,941 )
2024	2022	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	001	9	3/12/2024	NON-COMPETING CONTINUATION	-$404,835
2024	2021	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	000	8	3/12/2024	NON-COMPETING CONTINUATION	-$972,106
														Subtotal = -$1,376,941

Issue Date FY: 2022 ( Subtotal = $404,835 )
2022	2022	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	000	9	8/31/2022	NON-COMPETING CONTINUATION	$404,835
														Subtotal = $404,835

Issue Date FY: 2021 ( Subtotal = $3,933,025 )
2021	2021	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	004	8	8/25/2021	NON-COMPETING CONTINUATION	$3,933,025
2021	2020	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	003	7	5/19/2021	NON-COMPETING CONTINUATION	$0
2021	2019	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	002	6	12/30/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$3,081,319
2021	2019	WOMEN & INFANTS HOSPITAL OF RHODE ISLAND	101 DUDLEY ST	PROVIDENCE	RI	02905	PROVIDENCE	USA	Trans-NIH Research Support	001	5	12/30/2020	NON-COMPETING CONTINUATION	-$1,672,732
2021	2018	WOMEN & INFANTS HOSPITAL OF RHODE ISLAND	101 DUDLEY ST	PROVIDENCE	RI	02905	PROVIDENCE	USA	Trans-NIH Research Support	000	4	12/30/2020	EXTENSION WITH OR WITHOUT FUNDS	-$1,408,587
														Subtotal = $3,933,025

Issue Date FY: 2020 ( Subtotal = $2,822,489 )
2020	2020	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	004	7	8/15/2020	NON-COMPETING CONTINUATION	$3,950,813
2020	2019	WOMEN & INFANTS HOSPITAL OF RHODE ISLAND	101 DUDLEY ST	PROVIDENCE	RI	02905	PROVIDENCE	USA	Trans-NIH Research Support	000	5	1/8/2020	NON-COMPETING CONTINUATION	$0
2020	2019	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	003	6	4/15/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$3,508,435
2020	2019	WOMEN & INFANTS HOSPITAL OF RHODE ISLAND	101 DUDLEY ST	PROVIDENCE	RI	02905	PROVIDENCE	USA	Trans-NIH Research Support	002	5	4/15/2020	NON-COMPETING CONTINUATION	-$3,508,435
2020	2018	WOMEN & INFANTS HOSPITAL OF RHODE ISLAND	101 DUDLEY ST	PROVIDENCE	RI	02905	PROVIDENCE	USA	Trans-NIH Research Support	001	4	3/3/2020	EXTENSION WITH OR WITHOUT FUNDS	-$1,128,324
														Subtotal = $2,822,489

Issue Date FY: 2019 ( Subtotal = $7,955,739 )
2019	2019	WOMEN & INFANTS HOSPITAL OF RHODE ISLAND	101 DUDLEY ST	PROVIDENCE	RI	02905	PROVIDENCE	USA	Trans-NIH Research Support	002	5	9/17/2019	NON-COMPETING CONTINUATION	$5,181,167
2019	2018	WOMEN & INFANTS HOSPITAL OF RHODE ISLAND	101 DUDLEY ST	PROVIDENCE	RI	02905	PROVIDENCE	USA	Trans-NIH Research Support	001	4	9/17/2019	EXTENSION WITH OR WITHOUT FUNDS	$0
2019	2018	WOMEN & INFANTS HOSPITAL OF RHODE ISLAND	101 DUDLEY ST	PROVIDENCE	RI	02905	PROVIDENCE	USA	Trans-NIH Research Support	000	4	2/8/2019	EXTENSION WITH OR WITHOUT FUNDS	$2,774,572
														Subtotal = $7,955,739

Issue Date FY: 2018 ( Subtotal = $4,831,711 )
2018	2018	WOMEN & INFANTS HOSPITAL OF RHODE ISLAND	101 DUDLEY ST	PROVIDENCE	RI	02905	PROVIDENCE	USA	Trans-NIH Research Support	000	4	8/29/2018	EXTENSION WITH OR WITHOUT FUNDS	$4,831,711
														Subtotal = $4,831,711

Grand Total All Awards = $18,570,859

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ASSESSING THE EVOLVING IMPACT OF EARLY LIFE EXPOSURES ON CHILD PHYSICAL HEALTH AND NEURODEVELOPMENT

Award Number: UH3OD023313

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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