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ECHO II: Impact of environmental exposures on children's health and the co-morbidity of asthma and ADHD

Award Number: UH3OD023290
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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ECHO II: Impact of environmental exposures on children's health and the co-morbidity of asthma and ADHD - Our Children’s Center has provided an exemplary record of solution-oriented children’s environmental health research. From gestation through young adulthood, we have successfully followed children to address research questions relevant to the Northern Manhattan and South Bronx communities and beyond, for whom many complex childhood diseases are highly prevalent. We have documented effects of physical, chemical, and social exposures on airway diseases such as childhood asthma, and neurodevelopmental disorders such as Attention Deficit Hyperactivity Disorder (ADHD), two highly prevalent and frequently comorbid conditions with a large individual and societal burden. For the second phase of the ECHO consortium, in Aim 1 we will use ECHO-wide core data elements to examine common patterns of prenatal physical, chemical, and social exposures that associate with childhood asthma and ADHD to understand their contribution to both disorders and their well-established co-morbidity, which requires a large population such as ECHO to study. The ECHO cohort provides a unique opportunity to examine robustly if prenatal exposure patterns contribute to asthma/ADHD comorbidity via shared or distinct causal pathways. This science will address current gaps in knowledge that will improve strategies for prevention and treatment by: 1) raising risk-awareness; 2) increasing referrals for assessment of comorbid disorders; and 3) allowing for earlier intervention. In Aim 2, we will contribute to the development of specialized protocols by proposing to measure biomarkers of prenatal chemical exposure using a novel bioassay and adding annual measures of asthma and ADHD and their phenotypes to identify patterns of prenatal physical, chemical, and social exposures that associate with incident asthma and ADHD as well as their phenotypes that may have distinct etiologies. This more granular characterization of exposure and heterogenous outcomes will enable more precise strategies for early identification and prevention along with primary and tertiary interventions for asthma and ADHD. In Aim 3, we will implement the ECHO Cohort Protocol with high fidelity, maximizing the retention of existing ECHO participants and supporting the continued recruitment of new pregnant and preconception women. In Exploratory Aim 4, we will evaluate the role of chemical exposures during the preconception period on pregnancy loss, birth outcomes and early indicators of respiratory and neurodevelopmental health. Altogether, this proposal is intended to make large scientific impact on children’s health by both contributing substantially to the ECHO consortium, and by leading consortium science that should positively impact clinical practice.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,884,884 )
2025	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Trans-NIH Research Support	000	10	6/5/2025	EXTENSION WITH OR WITHOUT FUNDS	$3,884,884
														Subtotal = $3,884,884

Issue Date FY: 2024 ( Subtotal = -$212,589 )
2024	2022	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	001	7	4/2/2024	SUPPLEMENT FOR EXPANSION	-$12,986
2024	2022	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	000	7	4/2/2024	NON-COMPETING CONTINUATION	-$121,405
2024	2022	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	002	7	4/2/2024	SUPPLEMENT FOR EXPANSION	-$78,198
														Subtotal = -$212,589

Issue Date FY: 2022 ( Subtotal = $2,867,743 )
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	001	7	8/11/2022	NON-COMPETING CONTINUATION	$1,637,709
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	006	7	8/30/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	004	7	8/16/2022	SUPPLEMENT FOR EXPANSION	$175,174
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	003	7	8/15/2022	SUPPLEMENT FOR EXPANSION	$962,823
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	005	7	8/19/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	002	7	8/12/2022	SUPPLEMENT FOR EXPANSION	$92,037
2022	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	000	6	6/3/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,867,743

Issue Date FY: 2021 ( Subtotal = $2,501,290 )
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	003	6	8/16/2021	SUPPLEMENT FOR EXPANSION	$91,018
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	004	6	8/17/2021	SUPPLEMENT FOR EXPANSION	$770,945
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	002	6	8/13/2021	NON-COMPETING CONTINUATION	$1,639,327
2021	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	000	5	12/18/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	001	5	4/9/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,501,290

Issue Date FY: 2020 ( Subtotal = $1,962,992 )
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	001	5	8/14/2020	NON-COMPETING CONTINUATION	$1,639,327
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	002	5	8/17/2020	SUPPLEMENT FOR EXPANSION	$323,665
2020	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	000	4	6/15/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,962,992

Issue Date FY: 2019 ( Subtotal = $2,116,462 )
2019	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	002	4	9/11/2019	NON-COMPETING CONTINUATION	$1,989,326
2019	2018	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	000	3	2/7/2019	EXTENSION WITH OR WITHOUT FUNDS	$127,136
2019	2018	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	001	3	9/6/2019	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $2,116,462

Issue Date FY: 2018 ( Subtotal = $1,639,255 )
2018	2018	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Trans-NIH Research Support	000	3	8/29/2018	EXTENSION WITH OR WITHOUT FUNDS	$1,639,255
														Subtotal = $1,639,255

Grand Total All Awards = $14,760,037

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ECHO II: Impact of environmental exposures on children's health and the co-morbidity of asthma and ADHD

Award Number: UH3OD023290

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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