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Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methods

Award Number: UH3OD023286
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Obesity and asthma are the two most common chronic conditions in children. Obesity is a risk factor for asthma as well as for dyspnea not associated with airflow obstruction. Reciprocally, asthma symptoms and some asthma medications may increase risk of excess weight gain. Because no effective cures exist, and because both conditions are often established before school age, early life prevention is critical. Yet our ability to identify the most promising environmental or behavioral targets for prevention has been hampered by the fact that many exposures may be difficult to measure, often overlap and interact, and rarely occur at a single point in time. Individuals may vary in their sensitivity to exposures because of genetic or other factors. Furthermore, obesity and asthma themselves are not static – each may first emerge in early childhood, later childhood, adolescence, or adulthood; once present they may persist, remit, or worsen; and the two outcomes may interact. Sophisticated analytic approaches are needed to handle the complex natures of both longitudinal birth cohort data as well as of the questions themselves. To this end, we propose this project, which is grounded in our large Boston-area Project Viva pre-birth cohort. We recruited mothers in early pregnancy, and have followed them and their children at frequent in-person visits (after delivery and at infancy, early childhood, mid-childhood, and the nearly completed early teen visits) as well as via annual questionnaires. Building on the outcomes we have already assessed from birth through early adolescence, we now propose to characterize adiposity and cardiometabolic health measures as well as lung function and respiratory symptoms into the mid-teen years. Using state of the art statistical methods, we will address the early life environmental exposures that, singly and as mixtures, influence the separate and co-evolution of obesity, asthma and related dysfunctions. We will refine exposure measures, characterize outcome trajectories, and disentangle confounding, mediation and moderation in associations of exposures with outcomes. Finally, we will use agent based simulation models that will draw from but also go beyond the results from our own cohort, to identify optimal levers for effective intervention, incorporating multiple levels of action from physiologogy all the way up to policy. We will contribute the data, measures, and methods we refine within our cohort to the larger ECHO enterprise, as well as findings to be followed up in the large synthetic cohort with its diversity representative of children nationwide.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Trans-NIH Research Support	000	7	10/11/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Trans-NIH Research Support	000	7	4/26/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $2,277,362 )
2022	2022	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Trans-NIH Research Support	001	7	8/19/2022	NON-COMPETING CONTINUATION	$2,277,362
2022	2021	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Trans-NIH Research Support	000	6	5/30/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,277,362

Issue Date FY: 2021 ( Subtotal = $2,271,767 )
2021	2021	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Trans-NIH Research Support	001	6	8/25/2021	NON-COMPETING CONTINUATION	$2,271,767
2021	2020	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Trans-NIH Research Support	000	5	8/3/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,271,767

Issue Date FY: 2020 ( Subtotal = $2,277,365 )
2020	2020	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Trans-NIH Research Support	001	5	8/14/2020	NON-COMPETING CONTINUATION	$2,277,365
2020	2019	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Trans-NIH Research Support	000	4	11/6/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,277,365

Issue Date FY: 2019 ( Subtotal = $3,200,594 )
2019	2019	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Trans-NIH Research Support	001	4	9/6/2019	NON-COMPETING CONTINUATION	$2,627,236
2019	2018	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Trans-NIH Research Support	000	3	2/7/2019	EXTENSION WITH OR WITHOUT FUNDS	$573,358
														Subtotal = $3,200,594

Issue Date FY: 2018 ( Subtotal = $2,277,365 )
2018	2018	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Trans-NIH Research Support	000	3	8/29/2018	EXTENSION WITH OR WITHOUT FUNDS	$2,277,365
														Subtotal = $2,277,365

Grand Total All Awards = $12,304,453

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Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methods

Award Number: UH3OD023286

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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