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Prenatal Exposures and Child Health Outcomes 2: A Statewide Study of Michigan Families

Award Number: UH3OD023285
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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Prenatal Exposures and Child Health Outcomes 2: A Statewide Study of Michigan Families - This project will be conducted by investigators from a coalition of Michigan institutions that participated in ECHO Cycle 1. We began with two prospective observational cohort studies—the Archive for Research on Child Health (ARCH) and the Michigan ARCH (MARCH). Participants in the ARCH cohort were enrolled at first prenatal visit, largely in Lansing, MI, between 2008 – 2016. In 2016, we expanded recruitment to create the MARCH cohort, which is a stratified random sample of births in the lower peninsula of MI. In MARCH, we aimed for a statewide sample of 1,000 births and then chose to enroll an additional 100 births in Flint, MI. As of March of 2025, 1,150 participants joined ECHO Cycle 2, including new pregnancies, with high follow-up rates (91% of core data elements, 76% of all possible biospecimens). Our aims will contribute to ECHO science by: Aim 1. Using core ECHO data, we will investigate the effects of a) micronutrient levels in pregnancy; b) early infancy feeding patterns and the gut microbiome; and c) early life adversity at multiple intersecting levels of maternal, family, and neighborhood stressors, in relation to child health outcomes. Aim 2. We will study the effects of mixtures of per- and polyfluoroalkyl substances (PFAS), phthalates and heavy metals in pregnancy on child body mass index, metabolic function, and neurodevelopment, examining the gut microbiome as a potential effect mediator/modifier. Aim 3. We will follow the ECHO participants from our current cohorts, continue to reconsent our ARCH and MARCH cohort participants into ECHO-2, and recruit additional pregnant women to the ECHO cohort. We also aim to enroll approximately 225 mothers of the anticipated 450 live births for pre-conceptional data collection from whom we anticipate enrolling 67 subsequent children to produce a total study sample of approximately 2,200 Michigan families. Aim 4. We will examine preconception exposures in men that accelerate sperm epigenetic aging for their effects on offspring neurodevelopment and obesity and test the hypothesis that we can identify a signature of the extracellular preconditioned secretome in the circulating plasma of pre- conceptional women that is associated with an increased risk of recurrent preterm birth. When we have completed our recruitment and detailed assessments of pregnant women, their children, and conceiving partners where feasible, we will be able to make a very substantial contribution to the overall goals of the ECHO program


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $4,638,769 )
2025	2025	HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES	426 AUDITORIUM RD	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	000	10	6/6/2025	EXTENSION WITH OR WITHOUT FUNDS	$4,638,769
														Subtotal = $4,638,769

Issue Date FY: 2024 ( Subtotal = -$122,302 )
2024	2023	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	001	7	4/2/2024	SUPPLEMENT FOR EXPANSION	-$120,795
2024	2022	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	000	7	4/2/2024	NON-COMPETING CONTINUATION	-$1,507
														Subtotal = -$122,302

Issue Date FY: 2023 ( Subtotal = $120,795 )
2023	2023	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	000	7	1/26/2023	SUPPLEMENT FOR EXPANSION	$120,795
2023	2022	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	002	7	4/17/2023	NON-COMPETING CONTINUATION	$0
2023	2022	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	001	7	2/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $120,795

Issue Date FY: 2022 ( Subtotal = $2,901,575 )
2022	2022	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	001	7	8/25/2022	NON-COMPETING CONTINUATION	$2,901,575
2022	2021	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	000	6	2/2/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,901,575

Issue Date FY: 2021 ( Subtotal = $3,134,429 )
2021	2021	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	001	6	8/25/2021	NON-COMPETING CONTINUATION	$2,901,575
2021	2021	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	002	6	8/27/2021	SUPPLEMENT FOR EXPANSION	$120,795
2021	2021	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	003	6	8/28/2021	SUPPLEMENT FOR EXPANSION	$112,059
2021	2020	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	000	5	4/9/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,134,429

Issue Date FY: 2020 ( Subtotal = $3,564,847 )
2020	2020	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	002	5	8/18/2020	SUPPLEMENT FOR EXPANSION	$112,059
2020	2020	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	004	5	8/20/2020	SUPPLEMENT FOR EXPANSION	$245,534
2020	2020	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	001	5	8/17/2020	NON-COMPETING CONTINUATION	$2,901,575
2020	2020	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	003	5	8/19/2020	SUPPLEMENT FOR EXPANSION	$305,679
2020	2019	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	000	4	4/1/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,564,847

Issue Date FY: 2019 ( Subtotal = $4,042,364 )
2019	2019	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	002	4	9/12/2019	NON-COMPETING CONTINUATION	$3,297,170
2019	2018	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	000	3	10/26/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
2019	2018	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	001	3	2/5/2019	EXTENSION WITH OR WITHOUT FUNDS	$745,194
														Subtotal = $4,042,364

Issue Date FY: 2018 ( Subtotal = $3,057,227 )
2018	2018	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Trans-NIH Research Support	000	3	8/29/2018	EXTENSION WITH OR WITHOUT FUNDS	$3,057,227
														Subtotal = $3,057,227

Grand Total All Awards = $21,337,704

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Prenatal Exposures and Child Health Outcomes 2: A Statewide Study of Michigan Families

Award Number: UH3OD023285

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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