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ECHO-PROTECT Cohort Study Site in Puerto Rico

Award Number: UH3OD023251
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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ECHO-PROTECT Cohort Study Site in Puerto Rico - The effect of early environmental exposures on child health and development is an important area of public health that no single cohort, or even a few, can answer alone. Determining this effect becomes more challenging when considering that these exposures influence multiple interrelated health outcomes such as obesity, neurodevelopment and reproductive development. The ECHO Cohort Site in Puerto Rico (PR) will focus on these health outcomes, taking advantage of the rich and large sample size and longitudinal nature of the national ECHO Cohort and expertise across the ECHO consortium. The project will contribute innovative research to (Aim 1) examine the influence of environmental factors on maternal diet and obesity during pregnancy, child diet and obesity during early to middle childhood, and the relationship between maternal-child diet and onset of puberty and (Aim 2) determine the relationship between in utero and early childhood exposure to environmental chemicals, individually and as mixtures, and neurodevelopment and reproductive development, across early childhood, middle childhood, and adolescence. Most importantly, the project will build upon the ongoing ECHO cohort in PR (Aim 3) to follow up and collect data and biospecimens from the 800 children that are participating in the ECHO UG3 cohort, as well as recruit an additional 1,200 pregnant participants, yielding 1,000 more children, for a total of 1800 children contributing data and biospecimens to the ECHO Cohort. The proposed 1,200 new pregnancies will include at least 80 completed pregnancies with preconception data (Aim 4), tracked from a cohort of 470 potential preconception participants and, if available, their conceiving partner. This research will contribute meaningfully to ECHO’s mission, offering (a) an important cohort that will enrich consortium wide data, (b) significant, innovative science on the influence of the environment and exposure to multiple chemicals on multiple interrelated health outcomes such as obesity, neurodevelopment, and reproductive development, and (c) expertise to lead and participate in additional new scientific directions involving biomarkers of exposure or biologic response, child brain or reproductive development, and statistical methods in collaboration with the ECHO consortium, to answer impactful and cutting-edge research questions. Results from our study will inform future clinical intervention, risk assessment and policy-setting efforts, with direct relevance to the U.S. population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,924,196 )
2025	2025	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	000	10	6/10/2025	EXTENSION WITH OR WITHOUT FUNDS	$3,924,196
														Subtotal = $3,924,196

Issue Date FY: 2024 ( Subtotal = -$463,862 )
2024	2022	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	000	7	4/1/2024	NON-COMPETING CONTINUATION	-$463,862
														Subtotal = -$463,862

Issue Date FY: 2022 ( Subtotal = $3,118,380 )
2022	2022	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	000	7	8/18/2022	NON-COMPETING CONTINUATION	$3,118,380
2022	2022	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	001	7	8/29/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,118,380

Issue Date FY: 2021 ( Subtotal = $3,229,242 )
2021	2021	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	001	6	8/26/2021	SUPPLEMENT FOR EXPANSION	$110,862
2021	2021	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	000	6	8/25/2021	NON-COMPETING CONTINUATION	$3,118,380
														Subtotal = $3,229,242

Issue Date FY: 2020 ( Subtotal = $3,240,561 )
2020	2020	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	003	5	8/17/2020	SUPPLEMENT FOR EXPANSION	$122,181
2020	2020	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	002	5	8/14/2020	NON-COMPETING CONTINUATION	$3,118,380
2020	2019	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	000	4	12/13/2019	NON-COMPETING CONTINUATION	$0
2020	2019	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	001	4	5/5/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,240,561

Issue Date FY: 2019 ( Subtotal = $3,469,278 )
2019	2019	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	002	4	9/9/2019	NON-COMPETING CONTINUATION	$2,992,695
2019	2018	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	000	3	4/1/2019	EXTENSION WITH OR WITHOUT FUNDS	$476,583
2019	2018	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	001	3	4/9/2019	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $3,469,278

Issue Date FY: 2018 ( Subtotal = $2,642,695 )
2018	2018	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	000	3	8/29/2018	EXTENSION WITH OR WITHOUT FUNDS	$2,642,695
														Subtotal = $2,642,695

Grand Total All Awards = $19,160,490

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ECHO-PROTECT Cohort Study Site in Puerto Rico

Award Number: UH3OD023251

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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