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Environmental influences on Child Health Outcomes - The Colorado ECHO Pediatric Cohort

Award Number: UH3OD023248
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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Environmental influences on Child Health Outcomes - The Colorado ECHO Pediatric Cohort - PROJECT SUMMARY/ABSTRACT Chronic conditions, such as obesity, asthma, depression, and developmental disabilities, are increasing among children worldwide. Further, the age at diagnosis for many such conditions is decreasing, pointing to early-life origins. The developmental origins of health and disease (DOHaD) paradigm posits that exposures in utero and during early life influence phenotype and physiology as well as behaviors that shape lifelong health. Epidemiologic studies of DOHaD phenomena have historically focused on single exposure-health outcome associations, despite calls for more holistic approaches to capture the totality of exposures and their causal pathways. Other important limitations of prior work include study samples that diminish generalizability and limit opportunities to identify differences in health outcomes across subgroups and infrequent or lack of granularity in assessment of exposures and health outcomes across ontogeny. Together, these limitations hamper identification of when and how single and combinations of risk factors across early life culminate in chronic disease. This proposal addresses the above gaps by leveraging the Environmental influences on Child Health Outcomes (ECHO) Program to investigate a broad range of early-life exposures, from society to biology, in relation to pediatric health outcomes among ~50,000 caregiver-offspring pairs. The Colorado team will implement ECHO’s Core and Specialized Protocols in the Healthy Start Study, a Colorado pre-birth cohort that recruited and followed 1,250 mother-child dyads. In this cohort, exposures, and outcomes relevant to ECHO were collected during pregnancy, at birth, during infancy and the toddler years, and in early childhood (4-5 years). In the first ECHO Cycle, the Colorado team followed 765 children, to date, through middle childhood (8-12 years) and transferred extant data from pregnancy onward to the ECHO platform. In response to RFA-OD-22-019 and in collaboration with other ECHO components, our team will implement the ECHO Cohort Data and Biospecimen Collection Protocol with high fidelity and use community-engaged retention strategies to follow 750 participants aged 11-19 years to achieve two scientific objectives: (1) characterize patterns of contextual, chemical, and physical exposures during the in utero period and early childhood that predict co-occurring clusters of major ECHO outcomes through adolescence; and (2) examine joint effects of exposure to in utero overnutrition and childhood psychosocial adversity on the Specialized Outcome of pediatric obesity. The work proposed will facilitate a holistic understanding of how the totality of early-life exposures shape chronic disease risk in children; examine the involvement of a potentially modifiable biological mechanism (DNA methylation); and provide insights into multi-level targets for preventive action, including family- and individual-level factors that build resiliency in the face of unfavorable early exposures. The Colorado team brings to ECHO a group of investigators with complementary and synergistic expertise who are uniquely poised to lead innovative team science to steer solution-oriented research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,369,164 )
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	001	11	6/8/2026	NON-COMPETING CONTINUATION	$1,369,164
2026	2025	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	10	4/8/2026	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $1,369,164

Issue Date FY: 2025 ( Subtotal = $1,246,186 )
2025	2025	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	10	6/6/2025	EXTENSION WITH OR WITHOUT FUNDS	$1,246,186
														Subtotal = $1,246,186

Issue Date FY: 2024 ( Subtotal = -$30,632 )
2024	2022	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	7	4/1/2024	NON-COMPETING CONTINUATION	-$30,632
														Subtotal = -$30,632

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	7	6/21/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $2,462,168 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	002	7	9/1/2022	NON-COMPETING CONTINUATION	$0
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	001	7	8/16/2022	NON-COMPETING CONTINUATION	$2,462,168
2022	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	6	5/11/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,462,168

Issue Date FY: 2021 ( Subtotal = $2,462,168 )
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	002	6	8/26/2021	NON-COMPETING CONTINUATION	$0
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	001	6	8/24/2021	NON-COMPETING CONTINUATION	$2,462,168
2021	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	5	4/29/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,462,168

Issue Date FY: 2020 ( Subtotal = $2,813,882 )
2020	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	002	5	8/13/2020	NON-COMPETING CONTINUATION	$2,462,168
2020	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	003	5	8/20/2020	SUPPLEMENT FOR EXPANSION	$310,926
2020	2019	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	001	4	6/4/2020	NON-COMPETING CONTINUATION	$0
2020	2018	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	3	3/3/2020	EXTENSION WITH OR WITHOUT FUNDS	$40,788
														Subtotal = $2,813,882

Issue Date FY: 2019 ( Subtotal = $2,436,580 )
2019	2019	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	001	4	8/26/2019	NON-COMPETING CONTINUATION	$2,436,580
2019	2018	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	3	5/30/2019	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $2,436,580

Issue Date FY: 2018 ( Subtotal = $2,085,704 )
2018	2018	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	3	8/29/2018	EXTENSION WITH OR WITHOUT FUNDS	$2,085,704
														Subtotal = $2,085,704

Grand Total All Awards = $14,845,220

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Environmental influences on Child Health Outcomes - The Colorado ECHO Pediatric Cohort

Award Number: UH3OD023248

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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