Asian American Community Cohort and Engagement Study (ACCESS) - PROJECT SUMMARY/ABSTRACT Cardiometabolic disorders (e.g., hypertension, dyslipidemia, and type 2 diabetes) impose substantial health and economic burdens in the United States and are increasingly prevalent among Asian Americans. Despite lower average body mass indices, Chinese, Vietnamese, and Filipino adults experience elevated cardiometabolic risk, yet modifiable behavioral and biological pathways underlying this variation remain incompletely understood. Omega-3 fatty acid dietary supplements containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are widely used for perceived cardiometabolic benefits; however, real-world omega-3 supplement use, dose, formulation, and product characteristics are poorly characterized among disaggregated Asian American subgroups. This gap limits rigorous exposure assessment and constrains future biomarker-based studies evaluating omega-3 supplement use, biological response, and cardiometabolic health. The objective of this administrative supplement is to develop, pilot, and implement a culturally and linguistically adapted omega- 3 dietary supplement assessment module within the Asian American Community Cohort and Engagement Study (ACCESS), a Clinical/Community Field Center of the NHLBI-supported Multi-Omics Study of Asian American Community Health (MOSAAIC). ACCESS focuses on Chinese, Vietnamese, and Filipino adults aged 18-64 years in the greater Philadelphia region and collects harmonized dietary, behavioral, clinical, and biospecimen data. This supplement will leverage the ACCESS infrastructure to create a scalable approach for capturing product- level omega-3 supplement exposure. Aim 1 will develop and pilot an omega-3 supplement assessment module informed by established approaches used in NHANES, ASA24, and the Multiethnic Cohort Study. The module will capture product information, dose, frequency, and duration of use, and will be translated and adapted for ACCESS participants. Aim 2 will implement the refined module among approximately 700 newly enrolled participants and characterize omega-3 supplement use patterns, estimated EPA/DHA intake, and variation by ancestry subgroup, nativity, language preference, sociodemographic factors, and dietary fish intake. Aim 3 will evaluate feasibility, data quality, and readiness for future biomarker-based and cross-site omega-3 supplement research by developing standardized exposure-variable definitions, product harmonization decision rules, quality-control procedures, and a cross-site implementation package. This proposal aligns with ODS priorities related to dietary supplement use assessment, biological measures of supplement exposure, and future evaluation of supplement-related health effects in populations. Successful completion will generate preliminary data on omega-3 supplement use among Chinese, Vietnamese, and Filipino adults and establish a harmonized framework to support subsequent ODS/NHLBI applications integrating supplement assessment with objective omega-3 biomarkers and cardiometabolic phenotypes to investigate potential biological pathways.
