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Integrating HIV and hEART health in South Africa (iHeart-SA)

Award Number: UH3HL156388
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/25/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Integrating HIV and hEART health in South Africa (iHeart-SA) - ABSTRACT Our multidisciplinary, multi-country team of implementation science experts propose to adapt, implement, and evaluate the “Integrating HIV and hEART health in South Africa” (iHeart-SA) program that incorporates hypertension (HTN) and diabetes (DM) screening and treatment for people living with HIV (PLWH). SA is the epicenter of the HIV pandemic worldwide with over 7 million PLWH, of whom ~5 million are treated with anti- retroviral therapies (ART). ART rollout has two relevant repercussions: first, PLWH now have approximately twice the risk of developing HTN, DM, and cardiovascular disease (CVD); and second, the success of ART programs creates a corresponding mandate to deliver integrated, high-quality, sustainable treatment strategies to detect, treat, and control HTN and DM in HIV care. There are patient-, provider-, and system-level barriers to achieving these goals; but, there are also evidence-based interventions to address them, and we have extensive experience applying these to transform care for CVD co-morbidities in South Africa and India. We have determined the barriers to CVD care and reviewed the literature to select a package of interventions proven successful in randomized controlled trials, including: use of non-clinician care coordinators to support treatment documentation and quality improvement (QI); incorporation of home monitoring to enhance self- management; decision-support tools to facilitate treatment initiation and modifications; and monthly audit / feedback meetings to support continuous QI. We will use the EPIS framework and partner with government, academic, facility, and community stakeholders to guide the project by: Exploring (engaging stakeholders in human-centered design to co-adapt the intervention package to align with local capacity, opportunities, and motivations, Aim UG1); Preparing (strengthening capacity in implementation science, Aim UG2); Implementing and evaluating the intervention package via a stepped wedge cluster trial and assessing both implementation (e.g., reach, adoption, fidelity) and effectiveness (e.g., controlled blood pressure [primary outcome] among PLWH and HTN), Aim UH1; measuring Sustainability and costs after 24 months (where 12 months were spent transferring delivery from study to local staff (Aim UH2); and developing a strategy to scale up to rural clinics and nationally (Aim UH3). The overall goal of this project is to employ rigorous empirical methods to develop and test care innovations that expand the scope of HIV care in a sustainable, scalable, and impactful way. We will employ an achievable milestone plan to deliver high quality outputs, including: continued stakeholder relationships and co-ownership of the study over the project period; completion of three PhDs in implementation science; and disseminating findings via high-impact publications and presentations. We will also participate in NHLBI’s collaborative multi-institution network designed to strengthen research methods and impacts across all sites, and to advance training of the next generation of scientific leaders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	WITS HEALTH CONSORTIUM (PTY) LTD	31 PRINCESS OF WALES TERRACE	JOHANNESBURG				ZAF	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	5	3/24/2026	NON-COMPETING CONTINUATION	$418,977
2026	2024	WITS HEALTH CONSORTIUM (PTY) LTD	31 PRINCESS OF WALES TERRACE	JOHANNESBURG				ZAF	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	5	3/24/2026	NON-COMPETING CONTINUATION	-$418,977
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,218,970 )
2024	2024	WITS HEALTH CONSORTIUM (PTY) LTD	31 PRINCESS OF WALES TERRACE	JOHANNESBURG				ZAF	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	5	8/30/2024	NON-COMPETING CONTINUATION	$1,218,970
2024	2023	WITS HEALTH CONSORTIUM (PTY) LTD	31 PRINCESS OF WALES TERRACE	JOHANNESBURG				ZAF	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	4	4/10/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,218,970

Issue Date FY: 2023 ( Subtotal = $1,668,233 )
2023	2023	WITS HEALTH CONSORTIUM (PTY) LTD	31 PRINCESS OF WALES TERRACE PARKTOWN	JOHANNESBURG				ZAF	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	003	4	8/29/2023	SUPPLEMENT FOR EXPANSION	$299,997
2023	2023	WITS HEALTH CONSORTIUM (PTY) LTD	31 PRINCESS OF WALES TERRACE PARKTOWN	JOHANNESBURG				ZAF	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	002	4	8/25/2023	NON-COMPETING CONTINUATION	$835,818
2023	2022	WITS HEALTH CONSORTIUM (PTY) LTD	31 PRINCESS OF WALES TERRACE PARKTOWN	JOHANNESBURG				ZAF	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	3	3/3/2023	EXTENSION WITH OR WITHOUT FUNDS	$532,418
2023	2022	WITS HEALTH CONSORTIUM (PTY) LTD	31 PRINCESS OF WALES TERRACE PARKTOWN	JOHANNESBURG				ZAF	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	3	4/17/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $1,668,233

Issue Date FY: 2022 ( Subtotal = $835,461 )
2022	2022	WITS HEALTH CONSORTIUM (PTY) LTD	31 PRINCESS OF WALES TERRACE PARKTOWN	JOHANNESBURG				ZAF	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	3	9/15/2022	EXTENSION WITH OR WITHOUT FUNDS	$835,461
														Subtotal = $835,461

Grand Total All Awards = $3,722,664

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Integrating HIV and hEART health in South Africa (iHeart-SA)

Award Number: UH3HL156388

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/25/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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