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Phase I Study of Mesenchymal Stromal Cell Secretome for Promoting Corneal Regeneration

Award Number: UH3EY031809
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2020
PERIOD OF PERFORMANCE END DATE: 09/29/2025

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Phase I Study of Mesenchymal Stromal Cell Secretome for Promoting Corneal Regeneration - Summary The Mesenchymal Stromal Cell (MSC) Secretome Study is designed to assess the safety of allogeneic bone marrow-derived MSC secreted factors on the ocular surface, and also obtain a preliminary observation on 1) epithelial healing; 2) development of scarring; and 3) final visual acuity; with the objective of improving clinical outcomes in significant non-healing corneal epithelial disease. To achieve these goals, the MSC Secretome Study will include a Phase 1 safety and maximum tolerated dose study (Specific Aim #1) and a Phase 2a double- masked vehicle-controlled study to assess preliminary evidence of efficacy while identifying patient subgroups most likely to benefit from the treatment (Specific Aim#2).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $332,234 )
2024	2024	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Dietary Supplement Research Program	000	4	8/29/2024	SUPPLEMENT FOR EXPANSION	$332,234
														Subtotal = $332,234

Issue Date FY: 2023 ( Subtotal = $332,235 )
2023	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Vision Research	000	4	8/23/2023	NON-COMPETING CONTINUATION	$332,235
														Subtotal = $332,235

Issue Date FY: 2022 ( Subtotal = $333,060 )
2022	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	001	3	8/29/2022	NON-COMPETING CONTINUATION	$333,060
2022	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	000	2	8/29/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $333,060

Issue Date FY: 2021 ( Subtotal = $349,050 )
2021	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	000	2	9/10/2021	EXTENSION WITH OR WITHOUT FUNDS	$349,050
														Subtotal = $349,050

Grand Total All Awards = $1,346,579

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Phase I Study of Mesenchymal Stromal Cell Secretome for Promoting Corneal Regeneration

Award Number: UH3EY031809

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2020

PERIOD OF PERFORMANCE END DATE: 09/29/2025

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