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Research Infrastructure for the study of Alzheimer's Disease and Alzheimer's Disease-related dementias in older Asian Americans

Award Number: UH3AG083258
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Research Infrastructure for the study of Alzheimer's Disease and Alzheimer's Disease-related dementias in older Asian Americans - The older Asian American population has been rising, with the risk of Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) also increasing. However, the health needs of older Asian Americans are largely masked because this population is significantly understudied in clinical research. Social factors are an individual’s personal circumstances that influence their health and well-being. Social factors contribute to varied health outcomes and access. Research linking AD/ADRD to social factors is expanding rapidly, yet much evidence is still needed in older Asian Americans. Few studies incorporate health related risks, such as vascular conditions, and biomarkers to understand the link between social factors and AD/ADRD; and whether these mediate the relationship remains unclear. Using validated cognitive tests in English/Chinese and culturally relevant measures of sociodemographic factors, the study MPI (Li) successfully enrolled over 200 older Asian Americans in clinical research at the Alzheimer’s Disease Research Center (ADRC) at Mount Sinai. Here, the study team will grow to include multidisciplinary members, proposing a 5-year study to develop a research infrastructure for studying AD/ADRD in older Asian Americans. The social factor assessment will be available in English, Mandarin, and Cantonese – the most common spoken languages among Asian American older adults. This study will answer the following questions: (1) Do Chinese translation and cultural adaptation of social factor measures effectively recruit new and existing older Asian Americans in AD/ADRD research? (2) Can we identify behavior, environmental, social, genetic, and neurobiological factors associated with AD/ADRD? (3) How neurobiological processes intersect with environmental, sociocultural, behavioral, and other demographic factors to affect AD/ADRD outcomes? The study team will establish a scientific advisory board to provide scientific perspectives for the proposed study, particularly in the areas of (1) Social science; (2) Clinical phenotypes of AD/ADRD; (3) Dementia research in Asian Americans; and (4) Risk factors and biomarkers for AD/ADRD. The team will also collaborate with key community stakeholders to ensure that the social factor assessment is culturally and linguistically appropriate. Recruitment goal is set to be 300 older Asian Americans to complete a comprehensive dementia evaluation that includes social factor measurement. Novel, theory based social factor indices will be developed to characterize older Asian Americans in the normal, MCI, and AD/ADRD groups. Of the 300 enrollees, the study team aims to re-evaluate 100 participants for a 1-year follow-up and collect 200 biomarker samples for molecular profiling, including whole genome sequencing, RNA-sequencing and proteomics. Integrative network biology and machine learning will develop predictive diagnostic and prognostic molecular biomarkers of AD/ADRD. The UH2 phase will be used to develop the research infrastructure and assessment tools necessary to apply for a larger RO1 project at the end of the UH3 phase.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,244,248 )
2026	2026	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	001	4	8/12/2026	NON-COMPETING CONTINUATION	$1,244,248
2026	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	000	3	11/25/2025	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $1,244,248

Issue Date FY: 2025 ( Subtotal = $1,223,120 )
2025	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	000	3	8/25/2025	EXTENSION WITH OR WITHOUT FUNDS	$1,223,120
														Subtotal = $1,223,120

Grand Total All Awards = $2,467,368

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Research Infrastructure for the study of Alzheimer's Disease and Alzheimer's Disease-related dementias in older Asian Americans

Award Number: UH3AG083258

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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