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Brain-muscle microphysiological system enabled extracellular vesicle network for understanding aging in space

Award Number: UG3TR005829
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Brain-muscle microphysiological system enabled extracellular vesicle network for understanding aging in space - ABSTRACT Unveiling the brain-muscle axis associated with aging could be a key to many diseases, including Alzheimer's disease (AD) and Parkinson’s disease (PD) prevention and rehabilitation. Several modes of communication between the brain and muscle have been explored in the research field, including the emerging route via circulating extracellular vesicles (EVs). Elucidating an EV-enabled communication network between the brain and skeletal muscle could reveal essential molecular targets and signaling pathways, resulting in more effective therapeutic strategies to prevent brain aging and expand health span. We hypothesize that vital molecular drivers indicating the effects of microgravity on human brain-muscle physiology could be revealed to correlate with age-associated conditions. In UG3 PHASE (Year 1-Year 2), we will focus on the on-ground development of brain-muscle MPS to be used in microgravity environments. We will Integrate with the flight hardware provided by implementation partner for payload, functioning in an automatic regime, and recapitulating key features of brain-muscle physiology to achieve initial flight testing. In UH3 PHASE (Year 3-Year 5), we seek to understand microgravity effects and regenerative EVs on human brain-muscle physiology to correlate with age-associated conditions for therapeutic development. We will integrate the second space flight testing to achieve anti-apoptotic and regenerative potency assessment for therapeutic development using regenerative EVs. Our long-term goal is to establish space enabling brain-muscle MPS to understand brain-muscle physiology in space and develop EVs as a practical therapy approach to prevent aging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,344,810 )
2025	2025	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	National Center for Advancing Translational Sciences	000	1	8/1/2025	NEW	$2,318,060
2025	2025	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	National Center for Advancing Translational Sciences	001	1	8/11/2025	NEW	$26,750
														Subtotal = $2,344,810

Grand Total All Awards = $2,344,810

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Brain-muscle microphysiological system enabled extracellular vesicle network for understanding aging in space

Award Number: UG3TR005829

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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