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Machine-Assisted Interdisciplinary Approach For Early Clinical Evaluation of Neurodevelopmental Disorders

Award Number: UG3TR004033
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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Machine-Assisted Interdisciplinary Approach For Early Clinical Evaluation of Neurodevelopmental Disorders - ABSTRACT Neurodevelopmental delay is a feature of a majority of rare diseases and is often the first presenting sign. Nonspecific early presentations of rare disorders challenge both patients and caregivers who often struggle for years without diagnoses, and physicians who must distinguish between common concerns and rare disease. Early evaluations can streamline the diagnostic process and lead to rapid implementation of targeted therapies. In this proposal, our primary objective is to shorten the pathway to comprehensive genetic evaluations for suspected neurodevelopmental disorders (NDDs) through primary care electronic medical record (EMR) based machine-learning algorithmic identification of patients clinically eligible for genetic evaluation. We discuss our plan for integration of pretest genetic counseling in the primary care setting through video and telemedicine, and will develop a paradigm that can be adapted to the pediatric primary care workflow. We will implement and iteratively improve upon our algorithms during the UG3 Phase through a close partnership between academic geneticists, neurodevelopmental pediatricians, and the primary care pediatricians of Children’s Health Center (CHC) in Washington DC, and transition the mature program during the UH3 to all CNH Goldberg Center practices. We will thus bring early genetic evaluations to the largest network of primary pediatric practices in the D.C. Metropolitan area by leveraging our multidisciplinary team dedicated to early identification and characterization of NDDs. We will address the following aims: Aim 1 (UG3): Assess utility of a scalable machine-assisted pipeline for early identification of patients with NDDs based on automated feature extraction from EMR. We will train and iteratively refine a machine- learning algorithm to identify children at high risk of genetic NDDs based on their EMR. Aim 2 (UG3): Assess utility of a primary care clinician-initiated multidisciplinary evaluation to expedite genetic evaluation and neurodevelopmental phenotyping. Our workflow starting with automated chart identification will permit primary care providers access to our multidisciplinary neuro-developmental-genetics team. Technical innovations including telemedicine, application based videos, and electronic intakes will facilitate this process. Aim 3 (UH3): Evaluate generalizability of machine-assisted identification of NDDs from EMR by expanding access to entire network of Goldberg Center Pediatric practices. We will expand to all CNH primary care clinics serving the highly diverse Washington DC metropolitan area and ensure approach is robust to the specific demographic and epidemiologic factors of different sites. Our approach will identify patients with developmental delay in the primary care setting at the beginning of a diagnostic odyssey and expedite deep phenotyping and genetic investigations, as well as reevaluate sequencing results for early diagnosis in the diverse DC metropolitan population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	National Center for Advancing Translational Sciences	002	2	8/14/2024	NON-COMPETING CONTINUATION	$0
2024	2023	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	National Center for Advancing Translational Sciences	001	2	8/8/2024	NON-COMPETING CONTINUATION	$123,426
2024	2023	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	National Center for Advancing Translational Sciences	000	2	6/17/2024	NON-COMPETING CONTINUATION	-$123,426
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $350,274 )
2023	2023	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	National Center for Advancing Translational Sciences	000	2	2/1/2023	NON-COMPETING CONTINUATION	$350,274
														Subtotal = $350,274

Issue Date FY: 2022 ( Subtotal = $355,765 )
2022	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	National Center for Advancing Translational Sciences	000	1	1/25/2022	NEW	$355,765
														Subtotal = $355,765

Grand Total All Awards = $706,039

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Machine-Assisted Interdisciplinary Approach For Early Clinical Evaluation of Neurodevelopmental Disorders

Award Number: UG3TR004033

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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