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Organ-Chips as a Platform for Studying Effects of Space on Human Enteric Physiology: Interactions of Epithelial Mucosa with Sensory Neurons and Microbiome

Award Number: UG3TR002595
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2018
PERIOD OF PERFORMANCE END DATE: 12/31/2020

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Organ-Chips as a Platform for Studying Effects of Space on Human Enteric Physiology: Interactions of Epithelial Mucosa with Sensory Neurons and Microbiome - Abstract In response to the National Institutes of Health (NIH), -Center for the Advancement of Science in Space (CASIS), -Request for Application (RFA), -Targeted Research (TR), 18-001 we propose to apply the Organ-Chip technology of Emulate Inc., to assess the effects of space flight in human organs in vitro. Emulate is a newly founded start-up based on technology developed at the Wyss Institute at Harvard University in Cambridge, Massachusetts. The proposed work focuses on adding live imaging functionality to the automated hardware for space already being developed with Implementation Partners SpaceTango through the grant awarded from RFA-TR-16-019. This system will enable experiments in human, in vivo relevant microphysiological systems for understanding of the impact of microgravity and other space flight-imposed stressors on human physiology, disease development and response to interventions. We plan to further demonstrate the value of this automated platform by applying it to study a human innervated Intestine-Chip (hiIC) which includes colonic epithelial cells, lamina propria derived resident immune cells, enteric sensory neurons, and microbiome. Studies will investigate the immune response of this novel model to pathogenic bacteria with and without the incorporation of probiotic bacteria. Studies on identical hardware will be conducted on earth and on the International Space Station, and provide new insights into the influence of the space environment on immune response. The new imaging functionality will allow for real-time imaging of the organ-chips throughout their space journey and infection with pathogenic bacteria, giving an unprecedented view of how the system responds in this unique environment. Successful implementation of our space compatible hardware, and extending its application to our novel hiIC-chip, will show the value of an in vivo relevant, in vitro platform that can be utilized by the scientific community for the evaluation of the impact of microgravity in physiology and disease of a number of human organs, and support drug development in novel, clinically relevant ways.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	EMULATE, INC.	27 DRYDOCK AVE FL 5	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	2	7/11/2022	NON-COMPETING CONTINUATION	$0
2022	2019	EMULATE INC	27 DRYDOCK AVE	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	001	2	7/26/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	EMULATE, INC.	27 DRYDOCK AVE FL 5	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	2	11/26/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	EMULATE, INC.	27 DRYDOCK AVE FL 5	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	2	9/7/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $610,575 )
2019	2019	EMULATE, INC.	27 DRYDOCK AVE FL 5	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	001	2	9/9/2019	NON-COMPETING CONTINUATION	$610,575
2019	2018	EMULATE, INC.	27 DRYDOCK AVE FL 5	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	1	8/21/2019	NEW	$0
														Subtotal = $610,575

Issue Date FY: 2018 ( Subtotal = $460,257 )
2018	2018	EMULATE, INC.	27 DRYDOCK AVE FL 5	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	1	9/20/2018	NEW	$460,257
														Subtotal = $460,257

Grand Total All Awards = $1,070,832

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Organ-Chips as a Platform for Studying Effects of Space on Human Enteric Physiology: Interactions of Epithelial Mucosa with Sensory Neurons and Microbiome

Award Number: UG3TR002595

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2018

PERIOD OF PERFORMANCE END DATE: 12/31/2020

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