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Miami-ECHO: A Cohort of Mothers, Children and Fathers in Miami-Dade County

Award Number: UG3OD035542
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2023
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Miami-ECHO: A Cohort of Mothers, Children and Fathers in Miami-Dade County - PROJECT SUMMARY/ABSTRACT Variability in maternal and child health outcomes can emerge across generations, as stress experienced by mothers may influence their children’s development through both biological and psychological pathways. Without a clear understanding of the factors contributing to these outcome patterns—and without longitudinal assessment across large populations—important gaps in knowledge will remain. The Environmental influences on Child Health Outcomes (ECHO) Program seeks to advance understanding of how early life factors shape child health and development. To do this effectively, the program requires a large demographically representative cohort of children and their parents. We propose to establish the Miami-ECHO cohort site, composed of mothers, children, and fathers from Miami-Dade County (MDC), Florida. We will recruit and retain a large cohort of pregnant women (N=1,250), their offspring, and the conceiving father. In addition, we will enroll mothers who have a second pregnancy into the ECHO preconception protocol. Miami-Dade County (MDC) includes one of the largest highly dynamic urban population in the nation. Yet, this region is not currently represented in the ECHO Program. Our multidisciplinary team has longstanding access to the region’s largest health care settings and has collaborated with organizations that have served families in MDC for over 40 years. To advance the goals of ECHO science, we propose to address the following aims: A) Examine social environment and placental genome influences in children’s neurodevelopment and positive health (e.g., global health) outcomes. We will determine whether the placental genome mediates the relationship between pre- and perinatal factors and children's neurodevelopment and global health during early and middle childhood; and identify the interactive (gene x epigene x environment) effects on children's neurodevelopment and global health during early and middle childhood. B) Identify factors that protect against the effects of stressors on children’s neurodevelopment and positive health (e.g., global health) outcomes. We will distinguish the effects of stressors – separately and in combination – on children's neurodevelopment and global health from early to middle childhood; and determine the degree to which the early life factors and social support mediate the effects of stress on children's neurodevelopment and global health. C) Establish the Miami ECHO cohort site of mothers, children, and fathers. And D) Identify the effects of modifiable stressors and pre-conception health on pregnancy morbidity and birth outcomes. These aims will contribute to better understanding child health developmental outcomes in our nation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	UNIVERSITY OF MIAMI	1320 SOUTH DIXIE HIGHWAY STE 650	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Trans-NIH Research Support	000	2	11/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $4,428,532 )
2024	2024	UNIVERSITY OF MIAMI	1320 SOUTH DIXIE HIGHWAY STE 650	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Trans-NIH Research Support	000	2	5/21/2024	NON-COMPETING CONTINUATION	$4,428,532
														Subtotal = $4,428,532

Issue Date FY: 2023 ( Subtotal = $2,354,851 )
2023	2023	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 650	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Trans-NIH Research Support	000	1	8/10/2023	NEW	$2,354,851
														Subtotal = $2,354,851

Grand Total All Awards = $6,783,383

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Miami-ECHO: A Cohort of Mothers, Children and Fathers in Miami-Dade County

Award Number: UG3OD035542

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2023

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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