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Multisite closed loop DBS for Chronic Pain

Award Number: UG3NS146003
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Multisite closed loop DBS for Chronic Pain - PROJECT SUMMARY Chronic pain affects one out of four Americans and is often refractory to any treatment including medications, injections or surgery. Deep brain stimulation (DBS) involves implanting electrodes in key brain regions and holds promise as a new option for therapy, but we currently lack the technology to reliably achieve long-term pain symptom relief. A “one-size-fits-all” approach of continuous, 24/7 brain stimulation has helped patients with some movement disorders, but the key to reducing pain may be the activation of stimulation only when needed. This is called closed loop stimulation which may help to reduce side effects and keep the brain from adapting to stimulation effects. Further, because we know that an individual’s pain experience is processed by many brain regions and no single target works for all patients, DBS that targets these many regions may serve more patients and pain syndromes then just targeting one or two brain regions. We aim to develop a new brain stimulation device platform using personalized brain targets for hard-to-treat chronic pain and to improve technology that will enable the delivery of stimulation only when pain signals in the brain are high. This device platform provides a form factor and ease of use that addresses needs expressed to our team by previous patients and includes necessary technical capabilities that exceed any existing device. We will then test whether personalized stimulation, possible with this device, leads to reliable symptom relief for chronic pain patients over extended periods of time.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $387,647 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	21st Century Cures Act -Brain Research through Advancing Innovative Neurotechnologies	000	1	4/21/2026	NEW	$387,647
														Subtotal = $387,647

Grand Total All Awards = $387,647

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Multisite closed loop DBS for Chronic Pain

Award Number: UG3NS146003

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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