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Mesh Reinforced versus Sacrospinous Suture Hysteropexy for Uterine Prolapse: A Two-Arm Randomized Controlled Trial (MiSSion)

Award Number: UG3HD121025
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/11/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Mesh Reinforced versus Sacrospinous Suture Hysteropexy for Uterine Prolapse: A Two-Arm Randomized Controlled Trial (MiSSion) - PROJECT SUMMARY/ABSTRACT DESCRIPTION: State the application's broad, long-term objectives and specific aims, making reference to the health relatedness of the project (i.e., relevance to the mission of the agency). Describe the research design and methods for achieving the stated goals. Be sure that the project summary reflects the key focus of the proposed project so that the application can be appropriately categorized. Do not include proprietary/confidential information or trade secrets. DO NOT EXCEED THE SPACE PROVIDED. This research project focuses on improving the health and well-being of individuals experiencing pelvic organ prolapse (POP), a condition affecting many women’s quality of life. POP occurs when the muscles and tissues supporting the pelvic organs weaken, leading to a drop or bulge of these organs into or outside of the vaginal canal. Our long-term goal is to enhance treatment methods for POP, ensuring that they are safe, effective, and widely accessible. We aim to study two surgical techniques performed through a vaginal approach, comparing their outcomes to better understand their benefits and risks. These surgeries do not remove the uterus. Both surgeries lift the vagina and uterus back up. One surgery uses sutures only and the other surgery uses mesh. This knowledge will help guide future treatments, making them more effective and safer for patients and expanding options for patients allowing them to make more informed decisions on the ideal treatment option for them based on personal goals. To achieve these objectives, we will conduct a randomized study involving 242 individuals undergoing two surgical procedures. Participants will be carefully monitored over time for up to 3-5 years to assess the success and safety of each technique. We will look at aspects such as how well the surgery corrects the prolapse, recovery time, and any potential complications that might arise. Patient satisfaction, improvement, and quality of life will also be a crucial part of our evaluation. Through our research, we hope to provide valuable insights that will contribute to more informed choices for both health care providers and patients dealing with POP. The results will aim to shape future recommendations and improve the quality of care. This project aligns with the mission of promoting health improvements and advancing medical practices by optimizing the effectiveness of existing surgical treatments. By focusing on newer, promising surgical methods, we strive to revolutionize how POP is treated, making significant strides in women’s health. Our team is committed to ensuring that the outcomes of this study will have a meaningful impact on patients’ lives, offering them better treatment options and improving their overall quality of life by alleviating the burden of living with POP.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = $0 )
2027	2026	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Child Health and Human Development Extramural Research	000	1	10/27/2026	NEW	$0
														Subtotal = $0

Issue Date FY: 2026 ( Subtotal = $1,975,500 )
2026	2026	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Child Health and Human Development Extramural Research	000	1	9/16/2026	NEW	$1,975,500
														Subtotal = $1,975,500

Grand Total All Awards = $1,975,500

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Mesh Reinforced versus Sacrospinous Suture Hysteropexy for Uterine Prolapse: A Two-Arm Randomized Controlled Trial (MiSSion)

Award Number: UG3HD121025

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/11/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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