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Development of a Soluble Epoxide Hydrolase Inhibitor to Spare or Replace Opioid Analgesics

Award Number: UG3DA048767
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2022

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Development of a Soluble Epoxide Hydrolase Inhibitor to Spare or Replace Opioid Analgesics - Summary/Abstract EicOsis is developing a first-in-class analgesic with efficacy against neuropathic pain that will replace and dose spare opioids and thus prevent opioid use disorders (OUDs). The target of the small molecule inhibitor EC5026 is the soluble epoxide hydrolase, a master regulatory enzyme that modulates the activity of endogenous bioactive lipids. The development of EC5026 is currently in progress and progressing to an IND filing and is poised to have a high impact in treating chronic pain in humans. In this proposal we outline aims to reach the next steps in clinical human clinical trials with EC5026 as well as additional preclinical studies to expand the efficacy into models of chronic pain conditions presenting in humans which are most frequently treated with opioids. Additionally, we propose detailed pharmacokinetic, metabolism and distribution studies that will provide the required information for advanced clinical trials examining efficacy in humans. We also propose to optimize a formulation to meet these needs. All of these individual aims are structured to meet 2 year milestones (UG3) and continue to the next planned steps in development (UH3) as these milestones are met. EicOsis is meeting current development goals and EC5026 is well positioned to meet the urgent need of reducing opioid use because even given the updated strategy to treating pain with multimodal approaches, pharmaceuticals are the foundation of treating pain. EC5026 represents a first-in- class analgesic that is not an opioid nor a NSAID but offers effective pain relief for chronic neuropathic pain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	EICOSIS LLC	1930 5TH ST	DAVIS	CA	95616	YOLO	USA	Drug Use and Addiction Research Programs	000	2	10/11/2023	NON-COMPETING CONTINUATION	$0
2024	2020	EICOSIS LLC	1930 5TH ST STE A	DAVIS	CA	95616	YOLO	USA	Drug Use and Addiction Research Programs	001	2	10/13/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	EICOSIS LLC	1930 5TH ST	DAVIS	CA	95616	YOLO	USA	Drug Use and Addiction Research Programs	000	2	12/7/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	EICOSIS, LLC	25242 COUNTY ROAD 95	DAVIS	CA	95616	YOLO	USA	Drug Use and Addiction Research Programs	000	2	8/3/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	EICOSIS, LLC	25242 COUNTY ROAD 95	DAVIS	CA	95616	YOLO	USA	Drug Use and Addiction Research Programs	000	2	6/11/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $3,046,519 )
2020	2020	EICOSIS, LLC	25242 COUNTY ROAD 95	DAVIS	CA	95616	YOLO	USA	Drug Use and Addiction Research Programs	003	2	9/22/2020	NON-COMPETING CONTINUATION	$0
2020	2020	EICOSIS, LLC	25242 COUNTY ROAD 95	DAVIS	CA	95616	YOLO	USA	Drug Use and Addiction Research Programs	002	2	8/19/2020	NON-COMPETING CONTINUATION	$3,046,519
2020	2019	EICOSIS, LLC	25242 COUNTY ROAD 95	DAVIS	CA	95616	YOLO	USA	Drug Use and Addiction Research Programs	001	1	8/18/2020	NEW	$0
2020	2019	EICOSIS, LLC	25242 COUNTY ROAD 95	DAVIS	CA	95616	YOLO	USA	Drug Use and Addiction Research Programs	000	1	12/11/2019	NEW	$0
														Subtotal = $3,046,519

Issue Date FY: 2019 ( Subtotal = $3,036,135 )
2019	2019	EICOSIS, LLC	25242 COUNTY ROAD 95	DAVIS	CA	95616	YOLO	USA	Drug Use and Addiction Research Programs	000	1	9/27/2019	NEW	$3,036,135
														Subtotal = $3,036,135

Grand Total All Awards = $6,082,654

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Development of a Soluble Epoxide Hydrolase Inhibitor to Spare or Replace Opioid Analgesics

Award Number: UG3DA048767

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2022

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