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Keeping it LITE 2: Exploring HIV Risk in Vulnerable Youth with Limited Interaction and Digital Health Intervention (LITE-2)

Award Number: UG3AI169631
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/19/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2024

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Keeping it LITE 2: Exploring HIV Risk in Vulnerable Youth with Limited Interaction and Digital Health Intervention (LITE-2) - ABSTRACT Despite advances in HIV diagnostics, care and prevention strategies, infection rates among adolescent and young adult sexual and gender minorities (SGM) continue to rise in the United States (US). There is an urgent need to describe the epidemiology and trajectories of HIV acquisition in this population and to offer age and culturally appropriate scalable prevention interventions to those at highest risk of infection in the US. This project will engage and retain young SGM in an innovative longitudinal cohort, enroll them in a dynamic established digital health retention platform (HMP; HealthMPowerment), monitor HIV risk and prevention behaviors and explore the socioecological factors that influence the use of new HIV prevention technologies (UG3 phase), while also allowing targeted testing of novel digital health interventions (UH3 phase). We will also test the efficacy of expanding the core version of HMP (HMP Basic) by adding adherence tools (HMP Enhanced) for those who are on PrEP or ART to improve adherence and persistence. In Aim 1, we will enroll and retain a large (n=6000; 3000/year), diverse cohort of sexually active, SGM adolescents and young adults, ages 13-34, using innovative digital recruitment, engagement and retention strategies. Over the course of the study, we will longitudinally characterize the sexual behavior, HIV transmission risk, and PrEP uptake trajectories of SGM youth utilizing epidemiological trajectory analyses to identify the most effective points of intervention (Aim 2). For Aim 3, we will launch a randomized clinical trial to examine the efficacy of HMP Enhanced to improve PrEP adherence among HIV-negative youth (n ≥750) and ART adherence among HIV-positive youth (n ≥150) compared to HMP Basic. Finally, we will maximize the productivity of the cohort by testing new and innovative digital health devices, HIV/STI diagnostics and interventions, informed by the previous aims as well as emerging NIH prevention priorities (Aim 4). Our investigative team has decades of experience with recruitment, prevention and care of SGM youth and large-scale longitudinal cohort studies. This study will capitalize upon productive existing partnerships and digital health expertise to articulate the drivers of the ongoing HIV epidemic among the most vulnerable populations in the US in order to identify the most effective, expeditious and scalable strategies to address this ongoing public health crisis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	THE HEKTOEN INSTITUTE FOR MEDICAL RESEARCH	1339 S WOOD ST	CHICAGO	IL	60608	COOK	USA	Allergy and Infectious Diseases Research	000	2	1/7/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	THE HEKTOEN INSTITUTE FOR MEDICAL RESEARCH	1339 S WOOD ST	CHICAGO	IL	60608	COOK	USA	Allergy and Infectious Diseases Research	000	2	2/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $1,100,000 )
2023	2023	THE HEKTOEN INSTITUTE FOR MEDICAL RESEARCH	1339 S WOOD ST	CHICAGO	IL	60608	COOK	USA	Allergy and Infectious Diseases Research	000	2	5/4/2023	NON-COMPETING CONTINUATION	$1,100,000
2023	2023	THE HEKTOEN INSTITUTE FOR MEDICAL RESEARCH	1339 S WOOD ST	CHICAGO	IL	60608	COOK	USA	Allergy and Infectious Diseases Research	001	2	8/31/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,100,000

Issue Date FY: 2022 ( Subtotal = $1,100,000 )
2022	2022	HEKTOEN INSTITUTE FOR MEDICAL RESEARCH, THE	1339 S WOOD ST # G	CHICAGO	IL	60608	COOK	USA	Allergy and Infectious Diseases Research	000	1	5/19/2022	NEW	$1,100,000
														Subtotal = $1,100,000

Grand Total All Awards = $2,200,000

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Keeping it LITE 2: Exploring HIV Risk in Vulnerable Youth with Limited Interaction and Digital Health Intervention (LITE-2)

Award Number: UG3AI169631

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/19/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2024

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