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Rhode Island Child Clinical Trials Collaborative

Award Number: UG1OD024951
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/23/2016
PERIOD OF PERFORMANCE END DATE: 06/30/2030

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Rhode Island Child Clinical Trials Collaborative - The Rhode Island Child Clinical Trials Collaborative (RI-CCTC) is an ideal clinical center for the ECHO ISPCTN. This application builds on our successes in the first two award periods, in which we were a top enrolling site, submitted five network study concepts, were the (co-) PI of three ISPCTN studies (ACT NOW Weaning, SAMBA, PhITT), and provided leadership to the network through our committee work. Our state’s demographic includes children from all over the globe, who have high rates of infant mortality, asthma, obesity, prematurity, mental health problems and special health care needs. These high-risk populations have not been previously included in many clinical studies, and thus is benefitting both directly and indirectly from RI-CCTC’s work. Rhode Island is uniquely organized for population-based research - one major obstetric hospital (80% of the state’s deliveries), one children’s hospital (90% of the state’s pediatric admissions), one health department, and an engaged community. These factors allow for effective enrollment, retention and follow-up of study participants, allowing RI-CCTC to make a strong impact on network studies. We leverage our rich network of collaborations with existing research, education and public health programs, and our national research network affiliations. These partners share our commitment to children’s health and child health research. The Brown University School of Public Health and the Alpert Medical School has recently created the Hassenfeld Child Health Innovation Institute (HCHII), which focuses on understanding the prenatal, perinatal and postnatal factors that lead to childhood asthma, obesity and autism. The RI-CCTC will leverage the resources of the HCHII to create a broader and more comprehensive research network to serve children in the state of RI. Investigators in the Schools of Public Health and Medicine have considerable expertise in the study of environmental exposures and their impact on children. The contact PI, Thomas Chun MD, MPH, has extensive experience with multi-center networks and their leadership, through his experience with the ECHO ISPCTN and the Pediatric Emergency Care Applied Research Network. Co-PI Abbot Laptook similarly has been a leader in both the ISPCTN and the NIH funded Neonatal Research Network. Co-PI Phyllis Dennery MD has had consistent NIH funding for her basic and translational research, participated in many training grants and multicenter clinical trials, and extensive research mentoring experience. The continuity of this leadership team will ensure RI-CCTC’s future success in fulfilling ECHO’s goals and mission. Our Specific Aims are to: 1) Continue to provide new opportunities for enrollment of patients in ECHO ISPCTN studies by building on our current collaborations between our academic research centers and community partners, and our Plan for Enhancing Community Perspectives; 2) Continue to provide leadership to the ECHO ISPCTN and ECHO Program by developing new clinical trials, serving on network committees, and disseminating study results; 3) Develop and expand programs to educate and mentor clinicians to become independent investigators.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $369,003 )
2025	2025	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	000	8	8/21/2025	COMPETING CONTINUATION	$369,003
														Subtotal = $369,003

Issue Date FY: 2024 ( Subtotal = $447,661 )
2024	2024	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	000	7	8/28/2024	NON-COMPETING CONTINUATION	$447,661
														Subtotal = $447,661

Issue Date FY: 2023 ( Subtotal = $447,661 )
2023	2023	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	001	6	8/7/2023	NON-COMPETING CONTINUATION	$447,661
2023	2022	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	000	5	2/16/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $447,661

Issue Date FY: 2022 ( Subtotal = $447,661 )
2022	2022	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	001	5	8/22/2022	NON-COMPETING CONTINUATION	$447,661
2022	2021	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	000	4	1/22/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $447,661

Issue Date FY: 2021 ( Subtotal = $447,661 )
2021	2021	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	004	4	8/26/2021	NON-COMPETING CONTINUATION	$447,661
2021	2020	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	002	3	5/31/2021	COMPETING CONTINUATION	$0
2021	2020	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	003	3	8/26/2021	COMPETING CONTINUATION	$0
2021	2020	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	001	3	2/20/2021	COMPETING CONTINUATION	$37,545
2021	2016	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Child Health and Human Development Extramural Research	000	2	2/20/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$37,545
														Subtotal = $447,661

Issue Date FY: 2020 ( Subtotal = $462,911 )
2020	2020	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Trans-NIH Research Support	000	3	8/20/2020	COMPETING CONTINUATION	$462,911
														Subtotal = $462,911

Issue Date FY: 2017 ( Subtotal = $1,704,713 )
2017	2016	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Child Health and Human Development Extramural Research	001	2	6/15/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2017	2016	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Child Health and Human Development Extramural Research	000	2	4/11/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,704,713
														Subtotal = $1,704,713

Grand Total All Awards = $4,327,271

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Rhode Island Child Clinical Trials Collaborative

Award Number: UG1OD024951

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/23/2016

PERIOD OF PERFORMANCE END DATE: 06/30/2030

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