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Evaluation of Long Acting Injectable (LAI) and Teen clubs in adolescents (ATTUNE)

Award Number: UG1MD019435
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/24/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Evaluation of Long Acting Injectable (LAI) and Teen clubs in adolescents (ATTUNE) - The 1.7 million adolescents living with HIV (ALHIV) globally urgently need interventions to help improve retention, adherence, and ultimately viral load suppression (VLS). With both high rates of incident infection and some of the lowest VLS rates, ALHIV experience high mortality with approximately 100 deaths per day. Successful interventions to improve retention and VLS among ALHIV in low- and middle-income countries (LMIC) remain limited. Video-based interventions that provide counseling to patients living with HIV have increased patient HIV knowledge, supported disclosure, fostered behavior change, and improved treatment adherence. Targeted messaging can be woven into culturally relevant films with engaging storylines and delivered at critical teachable moments. Films can be shown in high-volume clinics to deliver standardized counseling content while freeing up HCW time. While video-based interventions have the potential to address barriers to ALHIV ART retention and adherence, they are not commonly used throughout Sub-Saharan Africa (SSA). Our team was one of the first to pilot and study the impact of a video-based intervention on HIV service delivery; preliminary results have suggested high levels of patient and HCW satisfaction, improved ART knowledge, adherence, and retention. Based on these promising results, we propose to adapt, assess and support scale up of a tailored, video-based counseling package for ALHIV: VITAL (Video Intervention to Inspire Treatment Adherence for Life) Start for Adolescents (VS4A). Our study will examine the impact of VS4A on the primary composite outcome of retention and adherence (viral load <1000 copies/ml) in a multisite two-arm cluster randomized controlled trial (CRCT) with 1:1 randomization in Malawi. Our overall hypothesis is that VS4A will a) achieve broad reach, b) be acceptable and feasible to implement, c) improve adolescent VLS and several secondary outcomes; and d) be cost-effective at scale. If effective, VS4A can be an innovative, scalable tool to improve service delivery for ALHIV while also liberating HCW time and reducing health system burden in Malawi. Building on a 15-year partnership with the Malawi Ministry of Health (MOH), a track record of excellence and innovation in service to ALHIV, and a robust implementation science research portfolio, our team is poised to successfully implement the VS4A study and program and to use findings to support rapid, wide-scale dissemination and scale up.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	AFRICA HEALTH RESEARCH INSTITUTE	719 UMBILO RD	DURBAN				ZAF	Minority Health and Health Disparities Research	001	2	12/10/2025	SUPPLEMENT FOR EXPANSION	$0
2026	2025	AFRICA HEALTH RESEARCH INSTITUTE	719 UMBILO RD	DURBAN				ZAF	Minority Health and Health Disparities Research	000	2	12/10/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $1,000,661 )
2025	2025	AFRICA HEALTH RESEARCH INSTITUTE	719 UMBILO RD	DURBAN				ZAF	Minority Health and Health Disparities Research	003	2	9/16/2025	NON-COMPETING CONTINUATION	$0
2025	2025	AFRICA HEALTH RESEARCH INSTITUTE	719 UMBILO RD	DURBAN				ZAF	Minority Health and Health Disparities Research	001	2	8/27/2025	NON-COMPETING CONTINUATION	$478,993
2025	2025	AFRICA HEALTH RESEARCH INSTITUTE	719 UMBILO RD	DURBAN				ZAF	Minority Health and Health Disparities Research	002	2	9/8/2025	SUPPLEMENT FOR EXPANSION	$521,668
2025	2023	AFRICA HEALTH RESEARCH INSTITUTE	719 UMBILO RD	DURBAN				ZAF	Minority Health and Health Disparities Research	000	1	8/27/2025	NEW	$0
														Subtotal = $1,000,661

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	AFRICA HEALTH RESEARCH INSTITUTE	719 UMBILO RD	DURBAN				ZAF	Minority Health and Health Disparities Research	001	1	8/21/2024	NEW	$0
2024	2023	AFRICA HEALTH RESEARCH INSTITUTE	719 UMBILO RD	DURBAN				ZAF	Minority Health and Health Disparities Research	000	1	4/9/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $1,045,576 )
2023	2023	AFRICA HEALTH RESEARCH INSTITUTE	719 UMBILO RD	DURBAN				ZAF	Minority Health and Health Disparities Research	000	1	9/23/2023	NEW	$1,045,576
														Subtotal = $1,045,576

Grand Total All Awards = $2,046,237

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Evaluation of Long Acting Injectable (LAI) and Teen clubs in adolescents (ATTUNE)

Award Number: UG1MD019435

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/24/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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