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Pediatric Heart Network Regents of the University of Michigan

Award Number: UG1HL135665
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2017
PERIOD OF PERFORMANCE END DATE: 12/31/2023

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Pediatric Heart Network Regents of the University of Michigan - ABSTRACT This proposal leverages strengths across the University of Michigan to support the Michigan Congenital Heart Center as a productive collaborator, leader, and innovator in advancing efforts of the Pediatric Heart Network (PHN) toward improving care and outcomes of pediatric and congenital cardiovascular disease. Michigan Congenital Heart Center investigators have played key roles in many prior and ongoing PHN studies, including leading the Single Ventricle Reconstruction Trial (the first multicenter randomized trial in the pediatric cardiac surgery), directing the biorepository for several PHN studies, and leading the PHN Integrated CARdiac Data and Outcomes (iCARD) Collaborative. Continued participation of centers with strong clinical and research infrastructure, and experience in leading multi-center collaborative research is needed to further the important work of the PHN. In addition, there are new challenges in the current era, including conducting research more efficiently, better utilizing the ever-increasing volume of healthcare data, and investigating novel therapies and devices to drive further improvements in outcomes (particularly longer-term outcomes), and tailoring these to specific clinical and genetic profiles. Our proposal has two aims – first, we aim to serve as a collaborative participant and leader in furthering the work of the PHN to address important questions in pediatric and congenital cardiovascular disease. Our track record of success, and unique and comprehensive resources, infrastructure, and expertise will ensure our ability to participate fully across PHN studies and lead efficient and collaborative research. In particular, our expertise specifically related to the study of novel therapies and devices, assessment of longer-term outcomes (including neurodevelopment), and underlying genetic factors, will allow us to lead efforts to address key questions in these areas. Our numerous faculty with independent research funding, training resources, and mentoring expertise will foster our ability to compete successfully for extramural research funding to further support PHN activities. Second, we aim to lead innovative data integration and sharing efforts to foster novel and efficient PHN research. Our investigators have extensive expertise in this area, including pioneering initial linkages across large datasets in the field (supported by NHLBI R01 funding), and creating a state of the art platform to share information across centers within the Pediatric Cardiac Critical Care Consortium (PC4). Through our leadership of the recently formed PHN iCARD Collaborative, we will work to bring innovations in this area to the PHN, including integrating existing and emerging data to allow novel studies otherwise not possible, and to support more efficient conduct of research. Participation and leadership of the Michigan Congenital Heart Center will foster continued success of the PHN, and allow the network to meet the challenges of the current healthcare and research environments to continue to advance the treatment and outcomes of pediatric and congenital cardiovascular disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$1 )
2024	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Cardiovascular Diseases Research	000	7	6/28/2024	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$1

Issue Date FY: 2023 ( Subtotal = $340,964 )
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Cardiovascular Diseases Research	000	7	12/22/2022	NON-COMPETING CONTINUATION	$340,964
														Subtotal = $340,964

Issue Date FY: 2022 ( Subtotal = $340,964 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cardiovascular Diseases Research	000	6	12/27/2021	NON-COMPETING CONTINUATION	$340,964
														Subtotal = $340,964

Issue Date FY: 2021 ( Subtotal = $340,964 )
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cardiovascular Diseases Research	000	5	12/15/2020	NON-COMPETING CONTINUATION	$306,868
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cardiovascular Diseases Research	001	5	12/28/2020	NON-COMPETING CONTINUATION	$34,096
2021	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cardiovascular Diseases Research	002	4	3/1/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $340,964

Issue Date FY: 2020 ( Subtotal = $340,964 )
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cardiovascular Diseases Research	001	4	4/2/2020	NON-COMPETING CONTINUATION	$17,049
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cardiovascular Diseases Research	000	4	1/1/2020	NON-COMPETING CONTINUATION	$323,915
														Subtotal = $340,964

Issue Date FY: 2019 ( Subtotal = $340,964 )
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cardiovascular Diseases Research	000	3	12/24/2018	NON-COMPETING CONTINUATION	$340,964
														Subtotal = $340,964

Issue Date FY: 2018 ( Subtotal = $340,964 )
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cardiovascular Diseases Research	000	2	12/21/2017	NON-COMPETING CONTINUATION	$334,145
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cardiovascular Diseases Research	001	2	7/7/2018	NON-COMPETING CONTINUATION	$6,819
														Subtotal = $340,964

Issue Date FY: 2017 ( Subtotal = $340,964 )
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cardiovascular Diseases Research	000	1	12/22/2016	NEW	$340,964
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cardiovascular Diseases Research	001	1	2/25/2017	NEW	$0
														Subtotal = $340,964

Grand Total All Awards = $2,386,747

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Pediatric Heart Network Regents of the University of Michigan

Award Number: UG1HL135665

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2017

PERIOD OF PERFORMANCE END DATE: 12/31/2023

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