Saturday, December 28, 2024 12/28/2024

NorthStar Node of the Clinical Trials Network

Award Number: UG1DA040316
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Since joining the NIDA National Drug Abuse Treatment Clinical Trials Network (CTN) in 2015, the NorthStar Node has made significant contributions to the objectives and priorities of the CTN. The NorthStar Node and its investigators have led or co-led five CTN protocols, served as a research site for seven CTN studies, co- chaired the CTN Steering Committee and the Data Science Work Group, served on the Research Development Committee, and contributed to several special interest groups. The NorthStar Node's research portfolio includes traditional randomized controlled trials (CTN-0068), pragmatic comparative effectiveness research (CTN-0098A and CTN-0099), implementation science (CTN-0074, CTN-0098B, and CTN-0099), community-based participatory research (CTN-0096), data science (CTN-0076 and CTN-0087), and health services research (CTN-0070). In this application, the NorthStar Node has seven guiding objectives (POLARIS): 1) generating evidence that informs Policy and clinical guidelines; 2) evaluating models addressing co-Occurring SUD and medical and psychiatric conditions; 3) using principals of a Learning health system to conduct pragmatic trials; 4) using Artificial intelligence and other data sciences approaches to enhance SUD research and care; 5) Reaching understudied populations to ensure SUD research is relevant to diverse populations; 6) using Implementation science to test the integration of evidence-based SUD practices into general medical settings; and 7) testing innovative Strategies for SUD treatment. Potential studies to meet these objectives include 1) a novel therapeutic intervention for methamphetamine use disorder; 2) development of machine learning algorithms in the electronic health record to target substance use screening and enhance substance use disorder diagnoses; 3) precision/personalized medicine studies using population pharmacokinetics to better define and refine medication dosing strategies that improve treatment outcome; and 4) testing collaborative care models to address co-occurring chronic medical illnesses in specialty addiction treatment settings. Our expertise spans multi-site clinical trials, implementation science, community-based participatory research, EHR-based interventions, machine learning and natural language processing, and health services research. In addition to community partners that include urban and rural integrated health systems, federally qualified health centers serving underrepresented minorities, specialty addiction treatment programs, and pediatric and adolescent health clinics, the NorthStar Node brings affiliated research and dissemination networks into the CTN, including CTSA, SIREN, PCORNet, JCOIN, HOPE, the Network Coordinating Office of the Addiction Technology Transfer Centers, a learning health system training program (K12), three NIDA training programs (T32), and fellowship programs in addiction medicine and addiction psychiatry. The NorthStar Node is well situated to address current and emerging SUD issues and advance research in the field in order to improve patient outcome and transform health systems.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$332,976 )
2024	2024	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	004	10	7/16/2024	NON-COMPETING CONTINUATION	$0
2024	2024	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	005	10	9/10/2024	NON-COMPETING CONTINUATION	$0
2024	2024	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	003	10	6/27/2024	NON-COMPETING CONTINUATION	$0
2024	2024	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	002	10	4/24/2024	NON-COMPETING CONTINUATION	$1
2024	2023	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	001	9	11/7/2023	NON-COMPETING CONTINUATION	$0
2024	2019	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	000	5	10/1/2023	SUPPLEMENT FOR EXPANSION	-$332,977
														Subtotal = -$332,976

Issue Date FY: 2023 ( Subtotal = $5,141,157 )
2023	2023	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	007	9	9/28/2023	NON-COMPETING CONTINUATION	$0
2023	2023	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	006	9	8/1/2023	NON-COMPETING CONTINUATION	$0
2023	2023	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	004	9	2/24/2023	NON-COMPETING CONTINUATION	$5,141,157
2023	2023	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	005	9	7/10/2023	NON-COMPETING CONTINUATION	$0
2023	2022	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	001	8	12/15/2022	SUPPLEMENT FOR EXPANSION	$0
2023	2022	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	000	8	11/10/2022	SUPPLEMENT FOR EXPANSION	$0
2023	2022	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	002	8	12/22/2022	NON-COMPETING CONTINUATION	$0
2023	2022	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	003	8	2/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,141,157

Issue Date FY: 2022 ( Subtotal = $7,868,193 )
2022	2022	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	001	8	3/1/2022	NON-COMPETING CONTINUATION	$629,634
2022	2022	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	005	8	9/2/2022	SUPPLEMENT FOR EXPANSION	$231,503
2022	2022	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	003	8	4/29/2022	SUPPLEMENT FOR EXPANSION	$6,507,913
2022	2022	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	004	8	7/19/2022	NON-COMPETING CONTINUATION	$0
2022	2022	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	006	8	9/13/2022	SUPPLEMENT FOR EXPANSION	$2
2022	2022	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	002	8	4/8/2022	NON-COMPETING CONTINUATION	$499,141
2022	2021	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	000	7	2/25/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $7,868,193

Issue Date FY: 2021 ( Subtotal = $8,719,566 )
2021	2021	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	012	7	8/24/2021	SUPPLEMENT FOR EXPANSION	$238,670
2021	2021	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	007	7	2/24/2021	NON-COMPETING CONTINUATION	$638,706
2021	2021	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	011	7	6/17/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	013	7	8/26/2021	SUPPLEMENT FOR EXPANSION	$278,025
2021	2021	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	014	7	8/27/2021	SUPPLEMENT FOR EXPANSION	$272,468
2021	2021	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	008	7	2/25/2021	SUPPLEMENT FOR EXPANSION	$230,666
2021	2021	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	010	7	6/3/2021	SUPPLEMENT FOR EXPANSION	$7,061,031
2021	2020	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	004	6	12/3/2020	COMPETING CONTINUATION	$4,533,943
2021	2020	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	009	6	3/11/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	005	6	2/12/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	006	6	2/12/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2019	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	001	5	12/3/2020	SUPPLEMENT FOR EXPANSION	-$2,205,580
2021	2019	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	000	5	12/3/2020	SUPPLEMENT FOR EXPANSION	-$965,579
2021	2019	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	002	5	12/3/2020	SUPPLEMENT FOR EXPANSION	-$1,170,074
2021	2019	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	003	5	12/3/2020	SUPPLEMENT FOR EXPANSION	-$192,710
														Subtotal = $8,719,566

Issue Date FY: 2020 ( Subtotal = $7,750,538 )
2020	2020	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	002	6	9/21/2020	SUPPLEMENT FOR EXPANSION	$385,408
2020	2020	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	003	6	9/22/2020	SUPPLEMENT FOR EXPANSION	$327,982
2020	2020	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	000	6	6/1/2020	COMPETING CONTINUATION	$646,605
2020	2020	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	004	6	9/23/2020	SUPPLEMENT FOR EXPANSION	$6,390,543
2020	2020	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	001	6	6/5/2020	COMPETING CONTINUATION	$0
														Subtotal = $7,750,538

Issue Date FY: 2019 ( Subtotal = $6,620,356 ) (Continued on the next page)
2019	2019	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	005	5	6/26/2019	SUPPLEMENT FOR EXPANSION	$1,219,146
2019	2019	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	006	5	6/27/2019	SUPPLEMENT FOR EXPANSION	$965,579
2019	2019	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Drug Use and Addiction Research Programs	004	5	5/9/2019	SUPPLEMENT FOR EXPANSION	$277,043
Grand Total All Awards = $40,529,607

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NorthStar Node of the Clinical Trials Network

Award Number: UG1DA040316

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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