Thursday, April 25, 2024 4/25/2024

Medication for Opioid Use Disorder, Predictability of Retention vs Attrition

Award Number: UG1DA015815
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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Abstract The Western States Node’s (WSN) research agenda for the National Drug Abuse Treatment Clinical Trials Network (CTN) competing renewal tests interventions to fill gaps in the Addiction Care Cascade, where progressively fewer people with drug use engage in treatment, receive pharmacotherapy, are retained in care, and experience sustained recovery. The Node proposes to continue the successful partnership between Oregon Health & Science University (OHSU; Todd Korthuis, MPI) and University of California San Francisco (UCSF; James Sorensen, Co-I), and adds Stanford University/Palo Alto VA (Keith Humphreys, MPI) to the collaboration. Six diverse health systems participate in WSN: 1) OCHIN, 2) The Palo Alto VA and national Veterans Healthcare Administration, 3) The OHSU health system, 4) Stanford Hospital and Clinics, 5) ProtoCall Services, Inc., and 6) Health Share and Trillium Medicaid managed care organizations. The WSN tests novel interventions that expand access to medications for opioid use disorder (MOUD). The overarching goal of the WSN’s competing renewal application is to conduct collaborative research within the CTN that fills gaps in the Addiction Care Cascade and thereby enhances the lives of people living with drug use disorders. Our Addiction Care Cascade-focused research agenda developed through conversations with diverse investigators and stakeholders including people who use drugs. Two research themes (medication trials and hybrid implementation trials to close gaps in the Addiction Care Cascade) provide four examples of CTN studies that could help close treatment gaps. In Research Theme 1 (medication trials), Medication Trial 1 targets people with OUD who are not interested in currently available MOUD and randomizes them to receive long acting oral hydromorphone versus facilitated referral methadone or buprenorphine to improve engagement and retention in treatment. Medication Trial 2 is a multisite phase 3 trial of mirtazapine versus placebo for people with methamphetamine use disorder to reduce methamphetamine use. In Research Theme 2 (hybrid implementation trials), two trials compare strategies to enhance engagement and retention on MOUD. Hybrid Effectiveness-Implementation Trial 1 is a cluster- randomized trial of telephonic + mHealth behavioral support services to improve retention on buprenorphine in primary care. Hybrid Effectiveness-Implementation Trial 2 tests a telementoring peer support intervention versus weekly peer supervision to improve peer success in engaging and retaining people who use drugs in treatment. We suffuse this research agenda with the Node’s infrastructure and expertise in vulnerable populations, health systems, electronic health records research, data science and clinical trials management. WSN offers these resources to the CTN network for use in future CTN protocols. Finally, WSN continues to use the CTN as a platform for training, dissemination, and research applications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	22	12/12/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $178,842 )
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	010	22	5/4/2023	NON-COMPETING CONTINUATION	$0
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	003	22	2/28/2023	NON-COMPETING CONTINUATION	$178,971
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	004	22	3/8/2023	NON-COMPETING CONTINUATION	$0
2023	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	009	17	3/22/2023	SUPPLEMENT FOR EXPANSION	-$1
2023	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	000	18	2/2/2023	SUPPLEMENT FOR EXPANSION	-$64
2023	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	005	18	3/22/2023	NON-COMPETING CONTINUATION	-$11
2023	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	001	18	2/2/2023	SUPPLEMENT FOR EXPANSION	-$27
2023	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	008	18	3/22/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	007	18	3/22/2023	SUPPLEMENT FOR EXPANSION	-$8
2023	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	006	18	3/22/2023	SUPPLEMENT FOR EXPANSION	-$19
														Subtotal = $178,842

Issue Date FY: 2022 ( Subtotal = $1,742,962 )
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	001	21	3/4/2022	NON-COMPETING CONTINUATION	$747,413
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	003	21	4/27/2022	NON-COMPETING CONTINUATION	$0
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	007	21	9/9/2022	SUPPLEMENT FOR EXPANSION	$100,731
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	004	21	5/13/2022	SUPPLEMENT FOR EXPANSION	$586,143
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	002	21	4/7/2022	SUPPLEMENT FOR EXPANSION	$308,675
2022	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	20	12/8/2021	NON-COMPETING CONTINUATION	$0
2022	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	006	19	8/2/2022	COMPETING CONTINUATION	$617,024
2022	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	005	18	8/2/2022	SUPPLEMENT FOR EXPANSION	-$617,024
														Subtotal = $1,742,962

Issue Date FY: 2021 ( Subtotal = $1,687,321 )
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	006	20	8/23/2021	NON-COMPETING CONTINUATION	$0
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	20	2/22/2021	NON-COMPETING CONTINUATION	$755,924
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	007	20	9/17/2021	SUPPLEMENT FOR EXPANSION	$97,989
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	002	20	5/25/2021	SUPPLEMENT FOR EXPANSION	$522,754
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	001	20	4/15/2021	SUPPLEMENT FOR EXPANSION	$310,654
2021	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	005	19	6/25/2021	COMPETING CONTINUATION	$1,244,456
2021	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	003	18	6/25/2021	SUPPLEMENT FOR EXPANSION	-$1,114,625
2021	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	004	18	6/25/2021	SUPPLEMENT FOR EXPANSION	-$129,831
														Subtotal = $1,687,321

Issue Date FY: 2020 ( Subtotal = $2,273,609 )
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	006	19	8/26/2020	COMPETING CONTINUATION	$0
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	004	19	7/29/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	003	19	7/28/2020	COMPETING CONTINUATION	$0
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	001	19	6/1/2020	SUPPLEMENT FOR EXPANSION	$1,020,413
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	002	19	6/2/2020	SUPPLEMENT FOR EXPANSION	$337,878
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	19	5/29/2020	COMPETING CONTINUATION	$915,318
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	005	19	7/30/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,273,609

Issue Date FY: 2019 ( Subtotal = $4,344,170 ) (Continued on the next page)
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	012	18	6/26/2019	SUPPLEMENT FOR EXPANSION	$2,200,084
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	009	18	6/21/2019	SUPPLEMENT FOR EXPANSION	$797,698
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	005	18	5/13/2019	SUPPLEMENT FOR EXPANSION	$8,660
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	006	18	5/31/2019	SUPPLEMENT FOR EXPANSION	$9,444
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	013	18	6/27/2019	SUPPLEMENT FOR EXPANSION	$129,831
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	007	17	6/19/2019	SUPPLEMENT FOR EXPANSION	$42,027
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	011	18	6/25/2019	SUPPLEMENT FOR EXPANSION	$286,011
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	008	17	6/20/2019	SUPPLEMENT FOR EXPANSION	$36,702
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	010	18	6/24/2019	SUPPLEMENT FOR EXPANSION	$142,146
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Drug Abuse and Addiction Research Programs	004	18	5/3/2019	NON-COMPETING CONTINUATION	$691,567
Grand Total All Awards = $18,463,422

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Medication for Opioid Use Disorder, Predictability of Retention vs Attrition

Award Number: UG1DA015815

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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