Tuesday, January 14, 2025 1/14/2025

CTN - Effects of semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro and Zepbound) on incidence and outcomes of stimulant use disorders and opioid use disorder in real-world populations: target tr

Award Number: UG1DA013732
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary (Abstract): Since its establishment in 2000, the Ohio Valley Node (OVN) has been one of the most productive of NIDA's Clinical Trials Network (CTN) nodes, both in leading and participating in multi-site trials. The OVN includes successful partnerships with four healthcare systems, two pharmacy networks, and six addiction specialty/ infectious disease programs. These collaborating sites span a seven-state region including some of the states most heavily impacted by opioid (Ohio, Kentucky, and West Virginia) and methamphetamine (Missouri, Kentucky, and North Dakota) use. The OVN includes Midwestern, Appalachian, Upper South, and Native American representation, which significantly enhances the geographical and cultural diversity of the CTN. The OVN Research Core is the driving force of the OVN and is led by Dr. Winhusen, one of the foremost experts in conducting multi-site addiction clinical trials in clinical practice settings. The OVN investigators have extensive expertise in substance use disorders (Winhusen, Brown, Burlew, Lyons, Montgomery, Lofwall, Walsh) and bioinformatics (Kaelber, Xu). The six members of the OVN research-implementation team bring > 60 years of combined experience conducting CTN clinical trials. If funded, our overall goal would be to utilize the wealth of experience and expertise gained over the past 19 years to conduct the research needed to address public health care crises, including the opioid use epidemic and the alarming increase in stimulant use. To this end, we would work with our healthcare partners to engage a diverse set of patients and service systems in areas highly impacted by substance use in CTN research. We would also contribute our expertise in conducting efficacy, effectiveness, and implementation trials testing the full range of interventions, from medications to behavioral interventions and health service innovations, for both opioid and stimulant use disorders. Moreover, we would contribute our expertise in the use of electronic health records for prospective and retrospective research studies, including the application of artificial intelligence to large healthcare datasets. In sum, we seek to continue providing scientific leadership, particularly on studies that could meaningfully impact clinical practice, and to effectively collaborate with a variety of professionals including treatment providers, investigators from diverse institutions, and staff of the Center for CTN (CCTN), clinical coordinating center (CCC) and data and statistics center (DSC) in support of the CTN mission.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $3,300,045 )
2024	2024	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	001	25	3/11/2024	NON-COMPETING CONTINUATION	$1,937,235
2024	2024	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	000	24	1/31/2024	SUPPLEMENT FOR EXPANSION	$146,310
2024	2024	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	004	25	9/6/2024	SUPPLEMENT FOR EXPANSION	$498,507
2024	2024	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	002	25	5/3/2024	NON-COMPETING CONTINUATION	$215,249
2024	2024	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	003	25	5/13/2024	NON-COMPETING CONTINUATION	$0
2024	2024	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	005	25	9/12/2024	SUPPLEMENT FOR EXPANSION	$502,744
														Subtotal = $3,300,045

Issue Date FY: 2023 ( Subtotal = $1 )
2023	2023	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	004	24	9/14/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	001	24	3/6/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	002	24	3/23/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	003	24	6/30/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	000	24	2/24/2023	NON-COMPETING CONTINUATION	$1
														Subtotal = $1

Issue Date FY: 2022 ( Subtotal = $3,186,833 )
2022	2022	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	001	23	2/28/2022	NON-COMPETING CONTINUATION	$768,017
2022	2022	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	006	23	8/18/2022	SUPPLEMENT FOR EXPANSION	$502,461
2022	2022	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	005	23	7/5/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	002	23	4/7/2022	SUPPLEMENT FOR EXPANSION	$1,537,390
2022	2022	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	007	23	9/8/2022	SUPPLEMENT FOR EXPANSION	$378,965
2022	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	000	22	10/12/2021	SUPPLEMENT FOR EXPANSION	$0
2022	2020	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	004	21	4/26/2022	COMPETING CONTINUATION	$100
2022	2019	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	003	20	4/26/2022	SUPPLEMENT FOR EXPANSION	-$100
														Subtotal = $3,186,833

Issue Date FY: 2021 ( Subtotal = $3,578,563 )
2021	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	010	22	9/23/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	009	22	8/27/2021	SUPPLEMENT FOR EXPANSION	$900,438
2021	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	006	22	5/28/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	007	22	8/2/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	004	22	5/5/2021	NON-COMPETING CONTINUATION	$408,420
2021	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	003	22	2/25/2021	NON-COMPETING CONTINUATION	$789,657
2021	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	008	22	8/26/2021	SUPPLEMENT FOR EXPANSION	$33,244
2021	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	005	22	5/27/2021	SUPPLEMENT FOR EXPANSION	$1,446,804
2021	2020	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	002	21	12/8/2020	COMPETING CONTINUATION	$2,901,270
2021	2019	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	001	20	12/8/2020	SUPPLEMENT FOR EXPANSION	-$2,457,513
2021	2019	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	000	20	12/8/2020	SUPPLEMENT FOR EXPANSION	-$443,757
														Subtotal = $3,578,563

Issue Date FY: 2020 ( Subtotal = $3,819,312 )
2020	2020	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	001	21	5/28/2020	SUPPLEMENT FOR EXPANSION	$2,424,851
2020	2020	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	000	21	5/27/2020	COMPETING CONTINUATION	$982,781
2020	2020	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	002	21	8/24/2020	SUPPLEMENT FOR EXPANSION	$411,680
														Subtotal = $3,819,312

Issue Date FY: 2019 ( Subtotal = $4,563,209 )
2019	2019	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	004	20	6/7/2019	SUPPLEMENT FOR EXPANSION	$652,568
2019	2019	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	005	20	9/18/2019	SUPPLEMENT FOR EXPANSION	$2,457,513
2019	2019	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	003	20	5/9/2019	SUPPLEMENT FOR EXPANSION	$315,312
2019	2019	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	000	20	4/9/2019	NON-COMPETING CONTINUATION	$725,165
2019	2019	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	001	19	4/10/2019	SUPPLEMENT FOR EXPANSION	$251,946
2019	2019	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	002	19	4/22/2019	SUPPLEMENT FOR EXPANSION	$160,705
														Subtotal = $4,563,209

Issue Date FY: 2018 ( Subtotal = $3,038,515 )
2018	2018	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	000	18	3/5/2018	SUPPLEMENT FOR EXPANSION	$318,750
2018	2018	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	003	19	7/23/2018	SUPPLEMENT FOR EXPANSION	$1,039,597
2018	2018	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	002	19	7/10/2018	SUPPLEMENT FOR EXPANSION	$940,908
2018	2018	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Drug Use and Addiction Research Programs	001	19	4/11/2018	NON-COMPETING CONTINUATION	$739,260
														Subtotal = $3,038,515

Grand Total All Awards = $24,976,188

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CTN - Effects of semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro and Zepbound) on incidence and outcomes of stimulant use disorders and opioid use disorder in real-world populations: target tr

Award Number: UG1DA013732

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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