Friday, April 25, 2025
4/25/2025
NIDA Clinical Trials Network: New York Node - Renewal-GY24 - Abstract With this fifth competing renewal application, the New York Node (NYN) will build on its existing structure, expertise, and partnerships to support NIDA's objectives to improve addiction care nationwide through research conducted by its Clinical Trials Network (CTN). Situated in the largest and most diverse U.S. metropolitan area, the NYN contributes expertise in virtually all key CTN priorities outlined in RFA-DA-25-027, including: capacity to conceptualize, design, lead, and support large trials; collaborations with health systems and community-based addiction treatment and harm reduction providers; and robust experience in developing and testing new therapies and delivery strategies, implementation science, community-engaged research, and using existing data sources to explore new research questions. The NYN is led by MPIs McNeely (New York University) and Nunes and Campbell (Columbia University), with deep CTN research experience and complementary expertise. Infrastructure: Includes two additional academic medical centers (Rutgers, Einstein-Montefiore), 7 large health systems, diverse community organizations and investigators that broaden the scope and improve the science and dissemination of our research. Multi-site clinical trials experience: Since inception, the NYN has led, or is leading, 25 CTN trials and ancillary studies. Accomplishments in the past 5 years include: 1) leading 5 completed multi-site trials; 2) leading 6 studies that will continue into the new funding cycle; 3) contributing sites to 3 other CTN trials; and 4) producing 92 peer-reviewed publications. Research agenda: The NYN works across the translational spectrum to develop and conduct trials of substance use disorder (SUD) interventions, using the Consolidated Framework for Implementation Research as an overarching conceptual model to keep adoption and implementation at the forefront of the work. Our six guiding themes for the new grant cycle are to conduct research that seeks to 1) Broaden the reach of SUD services to diverse populations through low-barrier and community-based treatment models; 2) Integrate evidence-based SUD treatment in healthcare settings, including medical settings and community programs; 3) Increase the effectiveness of SUD treatment by addressing mental health comorbidities; 4) Investigate novel treatments, including medications and digital therapeutics; 5) Use existing data sources to study interventions in real-world settings and inform new research questions by leveraging our experience with EHR and administrative data, advanced analytic methods, and a Data and Statistics Group supporting secondary analysis of CTN trials; and 6) Train the next generation of addiction researchers. The NYN proposes to conduct 6 new trials addressing CTN priorities, while also developing studies in partnership with our diverse SUD services partners and providing sites for studies led by other CTN nodes. Through these activities, the NYN advances the mission of the CTN to conduct research with high relevance for improving treatment practices and ameliorating the detrimental health impacts of substance use, by making evidence-based services more available, accessible, and acceptable to people with SUD.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).