Friday, January 2, 2026 1/2/2026

Integrated Transporter Elucidation Center

Award Number: UC2HD113039
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/14/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Integrated Transporter Elucidation Center - PROJECT SUMMARY/ABSTRACT Given their physiochemical properties, medications and dietary supplements often require active transport using solute carriers (SLC) and ATP-binding cassette (ABC) transporters to cross trophoblast barriers. These same transporters are also involved in the delivery of nutrients to the fetus and one unintentional consequence of drug therapy during pregnancy can be disruption of these shared systems. Therefore, understanding the interplay between SLC and ABC transporters in the placental disposition of drugs and nutrients is one key step to optimizing therapeutic interventions that improve perinatal healthcare. Our research team has championed the advancement of novel approaches to study SLC and ABC transporters in the placenta. To expand these efforts, we have created the Integrated Transporter Elucidation Center (InTEC) which leverages translational research expertise across 4 academic institutions. Our central hypothesis is that novel regulation and functions of placental transporters can be elucidated using integrated experimental, epidemiological, and modeling approaches. Together, data and models generated can predict the placental disposition of therapeutics and nutrients and their subsequent effects on fetal development. To accomplish this goal, we will 1) identify critical factors that regulate placental transporters using state-of-the-art quantitative targeted absolute proteomics and genetics in a US-based birth cohort; 2) develop a novel computational modeling framework that predicts maternal-fetal chemical disposition according to placental transporter functions and regulation; and 3) evaluate SLC and ABC transport in novel placenta-on-a-chip microphysiological systems. We will test nutrients, supplements, drugs, and toxicants as substrates and inhibitors of placental transporters. InTEC will enable rapid acceleration of placenta transporter research and establish best practices for transporter biology. Resources and datasets will be disseminated via our CIIPro webportal created in 2017. Unique training opportunities will be provided to early career scientists (undergraduate students, MS/MPH/PhD students, and postdoc fellows) and clinicians (obstetrics residents and fellows) at the intersections of pharmacology, computational biology, public health, maternal-fetal medicine, and biomedical engineering. Through innovative research and training, InTEC will lead to novel breakthroughs in the field of placental transport and ensure a well-trained workforce to improve maternal and perinatal health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	000	3	12/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $1,153,993 )
2025	2025	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	002	3	6/2/2025	NON-COMPETING CONTINUATION	$1,060,691
2025	2025	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	004	3	9/12/2025	SUPPLEMENT FOR EXPANSION	$93,302
2025	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	000	2	4/24/2025	NON-COMPETING CONTINUATION	$0
2025	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	003	2	7/11/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	001	2	5/1/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,153,993

Issue Date FY: 2024 ( Subtotal = $1,137,159 )
2024	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	001	2	9/11/2024	SUPPLEMENT FOR EXPANSION	$81,359
2024	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	000	2	7/10/2024	NON-COMPETING CONTINUATION	$1,055,800
														Subtotal = $1,137,159

Issue Date FY: 2023 ( Subtotal = $1,144,213 )
2023	2023	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	000	1	9/14/2023	NEW	$1,144,213
2023	2023	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	001	1	9/15/2023	NEW	$0
														Subtotal = $1,144,213

Grand Total All Awards = $3,435,365

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Integrated Transporter Elucidation Center

Award Number: UC2HD113039

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/14/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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