PROJECT SUMMARY OVERALL
The Jackson Laboratory (JAX) Center for Precision Genetics (JCPG) will develop and disseminate new,
precise mouse models that are tailored to match, as closely as possible, the disease characteristics of the
afflicted patients. Through a nomination process initiated by collaborating clinical experts, patients, advocates
or foundations, the JCPG Steering Committee will select and prioritize models for development and preclinical
data collection. The JCPG will leverage JAX's long-established expertise in bioinformatics, mammalian
genetics and disease modeling to integrate and refine existing resources, services and infrastructure to create
a pipeline for development of precision mouse models for the biomedical community. These mouse models
will then enter state-of-the-art animal facilities for maintenance and protection as they are prepared for
distribution to biomedical and research entities worldwide.
The JCPG expertise includes computational biologists, geneticists, molecular biologists, genetics technology
experts and many clinical collaborators in diverse disease areas. This team not only brings together broad
expertise in a range of human disease areas but also extensive ongoing experience in operating an array of
large-scale public resource services. This group has a proven ability to work effectively with clinical experts to
identify and delineate disease modeling needs as they emerge and then create new mouse models that serve
the varied needs of the diverse set of stakeholders that need mouse models to develop new clinical
treatments.
The activities of the JCPG seek to achieve the following five goals. 1. Assemble and refine a comprehensive,
scalable, and flexible pipeline for the generation and characterization of precision mouse models of human
disease. 2. Build a data analysis and dissemination infrastructure that facilitates development of next-
generation predictive models using an interactive public-facing process. 3. Accelerate the development of
novel, precision therapeutics by linking patient data with new precision animal models to inform preclinical
study design and generate the data needed for clinical trials. 4. Develop and deploy a robust outreach, project
nomination, and project management infrastructure that expands and facilitates access to all JCPG resources
by the public and biomedical community while promoting and distributing new mouse models through existing
infrastructure. 5. Gain efficiencies by integrating the JCPG with other JAX programs, resources, and external-
facing services and thereby establish a scalable, financially sustainable model development pipeline.