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African American Cardiovascular pharmacogenetic CONsorTium (ACCOuNT): discovery and translation

Award Number: U54MD010723
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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African American Cardiovascular pharmacogenetic CONsorTium (ACCOuNT): discovery and translation - DESCRIPTION (provided by applicant): The vast majority of pharmacogenomic studies have been conducted on exclusively European decent populations, thereby precluding the discovery and translation of African American specific genetic variation into precision medicine. This imbalance in discovery and translational science has hindered our ability to deliver precision medicine to 1 in 7 Americans. Currently several academic medical institutions are incorporating Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines into practice. Without accounting for new variants found exclusively in African Americans, clinical recommendations based solely on genetic biomarkers found in European populations could result in misclassification of drug response in African Americans. Furthermore, there are several well-established, clinically actionable pharmacogenomic associations (such as the antiplatelet agent, Clopidogrel) that completely lack discovery efforts in African Americans. Without both discovery and translational efforts in African Americans, precision medicine for all will not be a reality. A such, we formed a Transdisciplinary Collaborative Center (TCC) dubbed ACCOuNT (African American Cardiovascular pharmacogenetic Consortium) to discover novel genetic variants in African Americans related to clinically actionable cardiovascular phenotypes and to incorporating African American specific SNPs into clinical recommendations, which can be delivered to physicians at the point of care. We have partnered with academic institutions, patient organizations, and African American community leaders in both Chicago and in the District of Columbia (DC) to developed our focused effort in precision medicine. The TCC will consist of four cores (Administrative, Consortium, Implementation, and Data Analysis and Harmonization) as well as two research projects focused on discovery and translation of genetic findings. The primary aims of this proposal are: 1) Establish an African Ancestry pharmacogenomics research network to facilitate genomic research and to establish a public genomics resource for continued translational research; 2) Establish mechanisms to support implementation, diffusion, and continuing evaluation and improvement of precision medicine in African Americans; and 3) Engage community leaders in African American pharmacogenomic research. Our proposed TCC will be focused on closing this gap in precision medicine by undertaking discovery projects centering on SNP discovery in African Americans and clinical translational initiatives that will assess the impact of genetic biomarkers on clinical outcomes in African Americans in an inpatient setting. This model will establish a pipeline in which basic sciences discovery can pass quickly into clinical translational studies, which will in turn supply the needed clinical outcomes for implementation. We have incorporated patient centered approaches to each of these initiatives and have begun to work within African American communities on the design, recruitment and dissemination of this important work.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$18,273 )
2023	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	5	3/9/2023	NON-COMPETING CONTINUATION	-$18,273
														Subtotal = -$18,273

Issue Date FY: 2020 ( Subtotal = $1,995,641 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	002	5	6/8/2020	NON-COMPETING CONTINUATION	$1,995,641
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	001	4	4/23/2020	NON-COMPETING CONTINUATION	$0
2020	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	3	4/23/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,995,641

Issue Date FY: 2019 ( Subtotal = $1,768,551 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	001	4	5/23/2019	NON-COMPETING CONTINUATION	$1,768,551
2019	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	3	1/28/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,768,551

Issue Date FY: 2018 ( Subtotal = $1,833,557 )
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	3	5/24/2018	NON-COMPETING CONTINUATION	$1,650,202
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	001	3	6/20/2018	NON-COMPETING CONTINUATION	$183,355
														Subtotal = $1,833,557

Issue Date FY: 2017 ( Subtotal = $1,880,357 )
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	2	6/9/2017	NON-COMPETING CONTINUATION	$1,880,357
														Subtotal = $1,880,357

Issue Date FY: 2016 ( Subtotal = $2,049,060 )
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	1	8/19/2016	NEW	$2,049,060
														Subtotal = $2,049,060

Grand Total All Awards = $9,508,893

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African American Cardiovascular pharmacogenetic CONsorTium (ACCOuNT): discovery and translation

Award Number: U54MD010723

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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