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EYES OF AFRICA : THE GENETICS OF BLINDNESS

Award Number: U54HG009826
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2017
PERIOD OF PERFORMANCE END DATE: 06/30/2024

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EYES OF AFRICA : THE GENETICS OF BLINDNESS - Our Collaborative Center “Eyes of Africa: The Genetics of Blindness” will address the staggering economic, societal, and personal cost of irreversible blindness in Africa. The most common cause of permanent blindness in Africa is primary open angle glaucoma (POAG), which is the dominant type of glaucoma in Sub Saharan Africa (SSA). Multiple studies have found that glaucoma disproportionately affects people of African versus European ancestry. As a disease, POAG constitutes the single greatest cause of permanent blindness in Africa and for this reason is the focus of this proposal. We will identify new susceptibility genes for POAG in order to lay the foundation for novel therapeutic intervention, conduct the Sub-Saharan Africa Glaucoma Laser Trial (SSA-GLT) to identify the optimal approach for early treatment of glaucoma and conduct Targeted Glaucoma Screening in Sub Saharan Africa (TGS-SSA): An approach to identify glaucoma early and increase awareness of glaucoma in Sub-Saharan Africa. Successful completion will identify pre-symptomatic glaucoma for treatment, educate families about the disease, and identify highly penetrant mutations that give rise to early onset glaucoma. Our Collaborative Center will fight blindness in Africa in in multiple complementary and synergistic ways that address critical approaches to identify, treat, and understand POAG in Africa. We will build upon our existing large dataset of genotyped samples, expanding this resource using our extensive group of active subject recruitment sites distributed across Africa. In short, this proposal is designed to provide both an immediate and a long-lasting impact to reduce blindness in Africa.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$1 )
2025	2021	COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN	UNIVERSITY COLLEGE HOSPITAL	IBADAN				NGA	Trans-NIH Research Support	000	5	1/16/2025	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$1

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN	UNIVERSITY COLLEGE HOSPITAL	IBADAN				NGA	Trans-NIH Research Support	000	5	6/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	COLLEGE OF MEDICINE ,UNIVERSITY OF IBADAN	UNIVERSITY COLLEGE HOSPITAL	IBADAN				NGA	Trans-NIH Research Support	000	5	1/10/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $716,442 )
2021	2021	COLLEGE OF MEDICINE ,UNIVERSITY OF IBADAN	UNIVERSITY COLLEGE HOSPITAL	IBADAN				NGA	Trans-NIH Research Support	001	5	8/11/2021	NON-COMPETING CONTINUATION	$716,442
2021	2020	COLLEGE OF MEDICINE ,UNIVERSITY OF IBADAN	UNIVERSITY COLLEGE HOSPITAL	IBADAN				NGA	Trans-NIH Research Support	000	4	2/1/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $716,442

Issue Date FY: 2020 ( Subtotal = $722,255 )
2020	2020	COLLEGE OF MEDICINE ,UNIVERSITY OF IBADAN	UNIVERSITY COLLEGE HOSPITAL	IBADAN		200212		NGA	Trans-NIH Research Support	000	4	6/29/2020	NON-COMPETING CONTINUATION	$722,255
														Subtotal = $722,255

Issue Date FY: 2019 ( Subtotal = $750,000 )
2019	2019	COLLEGE OF MEDICINE ,UNIVERSITY OF IBADAN	UNIVERSITY COLLEGE HOSPITAL	IBADAN		200212		NGA	Human Genome Research	001	3	6/20/2019	NON-COMPETING CONTINUATION	$750,000
2019	2018	COLLEGE OF MEDICINE ,UNIVERSITY OF IBADAN	UNIVERSITY COLLEGE HOSPITAL	IBADAN		200212		NGA	Human Genome Research	000	2	1/4/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $750,000

Issue Date FY: 2018 ( Subtotal = $748,588 )
2018	2018	COLLEGE OF MEDICINE	UNIVERSITY COLLEGE HOSPITAL	IBADAN OYO STATE				NGA	Human Genome Research	000	2	8/23/2018	NON-COMPETING CONTINUATION	$748,588
														Subtotal = $748,588

Issue Date FY: 2017 ( Subtotal = $819,625 )
2017	2017	COLLEGE OF MEDICINE	UNIVERSITY COLLEGE HOSPITAL	IBADAN				NGA	Human Genome Research	001	1	9/27/2017	NEW	$69,625
2017	2017	COLLEGE OF MEDICINE	UNIVERSITY COLLEGE HOSPITAL	IBADAN				NGA	Human Genome Research	000	1	9/21/2017	NEW	$750,000
														Subtotal = $819,625

Grand Total All Awards = $3,756,909

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EYES OF AFRICA : THE GENETICS OF BLINDNESS

Award Number: U54HG009826

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2017

PERIOD OF PERFORMANCE END DATE: 06/30/2024

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