The Center for Innovation and Translation of Point of Care Technologies for Expanded Cancer Care Access (CITEC) - Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Cancer is the first or second leading cause of premature death in 134 of 183 countries, and it is estimated that global incidence of cancer will increase by 50% from 2018 to 2040. The number of cases is projected to double in countries with low Human Development Index; these countries have the least resources and infrastructure to adequately care for cancer patients. In the United States and other countries, cancer outcomes show wide variation depending on infrastructure, resources and contextual factors. Most cancers can be cured if detected early and treated effectively. To reduce premature death, the World Health Organization recommends implementing early cancer detection and prevention programs at the primary care level. Yet, existing tests for early cancer detection are too complex and/or expensive to implement in primary care or rural settings, with limited medical resources or infrastructure. We will establish the Center for Innovation and Translation of Point-of-Care Technologies for Expanded Cancer Care Access (CITEC) to identify high-priority clinical needs for POC cancer technologies; to accelerate development of effective, affordable technologies to meet these needs; to evaluate and improve the clinical and public health impact of POC technologies in a wide range of settings; and to train developers and users to create and disseminate more scalable POC technologies. CITEC will prioritize development of POC tests to detect cancers that arise in epithelial surfaces. Initially, we will focus on sites accessible for early detection because this is where POC technologies can have the most immediate impact. Targeted organ sites include the uterine cervix, gastro-intestinal tract (esophagus, stomach, colon, rectum, anus), and oral cavity; cancers in these sites account for 26% of global cases and 29% of global cancer deaths. CITEC builds on the highly productive 15-year collaboration between Rice University, The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, and The University of Texas Health Science Center at Houston to develop and translate novel POC technologies to improve cancer care in both low- and high-resource settings. Joining with collaborators in Brazil at The University of Sao Paulo and Barretos Cancer Hospital and partners in Mozambique at The Universidade Eduardo Mondlane and Ministry of Health, we will create a collaborative center to support technology development and engage and support a strong community of investigators dedicated to creating and scaling POC technologies for effective cancer screening and diagnosis to facilitate early treatment. CITEC will support development of POC technologies to promote high priority topics of NIH cancer research, including precision approaches to prevention, screening and early detection, improving cancer outcomes, and building a workforce able to translate POC technologies from research and development to implementation. CITEC will have a major impact on prevention, diagnosis and early treatment of cancer in the US and worldwide and will work with the POCTRN network to build a strong team of partners to strengthen and sustain POC technology development.
