Wednesday, July 2, 2025 7/2/2025

The Center for Innovation in Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern University (C-THAN)

Award Number: U54EB027049
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/11/2018
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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The Center for Innovation in Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern University (C-THAN) - SUMMARY - OVERALL The Center for Innovation in Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern (C-THAN) proposes to remain a member in the Point-of-Care Technologies Research Network (POCTRN) as a Technology Research and Development Center (TRDC). C-THAN will catalyze innovation in diagnostic technologies through a model that enhances complementary strengths to build multidisciplinary partnerships across technology platforms, clinical, regulatory and commercialization domains with a specific focus on HIV/AIDS and emerging infectious diseases in low- and middle-income countries (LMICs). The C-THAN structure will incorporate clinical, and user needs in the development process while providing expertise and resources to address early barriers to technologic development, validation, and commercialization. The scope of work entails: 1) assessment of unmet clinical needs in POC testing for HIV/AIDS, its co-morbidities, and emerging infectious diseases; 2) develop relevant solicitation topics to address unmet clinical needs; 3) award and manage sub-award projects made by C-THAN; 4) collaborate with relevant scientists, physicians, researchers and engineers; 5) develop essential technical, clinical, industrial and regulatory partnerships; 6) conduct clinical studies and/or provide access to specimens for validation testing of prototype devices; and 7) create training opportunities for technical developers and other stakeholders related to the development of POC and home-based devices. The range of technologies will include POC devices for detection of infection and monitoring of HIV/AIDS and its common potentially fatal co- morbidities including tuberculosis (TB), non-tuberculous mycobacterium (NTM), hepatitis B (HBV), hepatitis C (HCV) and HIV-associated malignancies. Furthermore, emerging, and re-emerging infectious diseases will be addressed by applying our strategy of addressing the urgent diagnostic need of POC testing for SARS-CoV-2 and other emerging infections such as mpox virus, Ebola, Lassa Fever, and Rift Valley Fever, among others. The United Nations Program on HIV and AIDS (UNAIDS) has set the ambitious goal of achieving a 95% detection rate for HIV, placing 95% of those individuals on treatment, and achieving 95% viral suppression in those that are treated. The major premise of this renewal proposal is that these goals will not be met without augmenting the current diagnostic platforms for HIV, its co-morbidities, and emerging infectious diseases with POCs that are affordable, rapid, and easy to use in LMICs requiring minimal skill and maintenance. An emphasis will be directed to specific technologic domains by establishing four working groups (WG) in molecular, lateral flow, synthetic biology, and product engineering. We will leverage the dynamic and productive collaborations established by Northwestern in Africa at nine academic centers in Nigeria, Mali, Senegal, Tanzania, and South Africa.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$593,438 )
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	1/15/2025	NON-COMPETING CONTINUATION	$0
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	7	3/28/2025	NON-COMPETING CONTINUATION	$0
2025	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	2/10/2025	SUPPLEMENT FOR EXPANSION	-$593,438
														Subtotal = -$593,438

Issue Date FY: 2024 ( Subtotal = $1,928,617 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	007	7	9/9/2024	SUPPLEMENT FOR EXPANSION	$250,000
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	006	7	7/30/2024	NON-COMPETING CONTINUATION	$1,678,617
2024	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	6	5/3/2024	COMPETING CONTINUATION	$0
2024	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	6	5/9/2024	COMPETING CONTINUATION	$0
2024	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	005	6	6/12/2024	COMPETING CONTINUATION	$0
2024	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	6	4/23/2024	COMPETING CONTINUATION	$2,092,326
2024	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	5	4/23/2024	SUPPLEMENT FOR EXPANSION	-$941,950
2024	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	4/23/2024	NON-COMPETING CONTINUATION	-$1,150,376
														Subtotal = $1,928,617

Issue Date FY: 2023 ( Subtotal = $1,754,217 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	6	9/15/2023	COMPETING CONTINUATION	$1,754,217
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	6	9/18/2023	COMPETING CONTINUATION	$0
2023	2022	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	5	9/8/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	9/7/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,754,217

Issue Date FY: 2022 ( Subtotal = $2,632,090 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	8/9/2022	NON-COMPETING CONTINUATION	$1,447,142
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	5	9/16/2022	SUPPLEMENT FOR EXPANSION	$1,184,948
2022	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	8/12/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,632,090

Issue Date FY: 2021 ( Subtotal = $1,536,895 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	4	6/29/2021	NON-COMPETING CONTINUATION	$1,536,895
2021	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	2	5/28/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	1/29/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	3	5/14/2021	NON-COMPETING CONTINUATION	$0
2021	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	11/10/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,536,895

Issue Date FY: 2020 ( Subtotal = $8,227,340 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	2	7/30/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	3	5/29/2020	NON-COMPETING CONTINUATION	$1,519,571
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	5/22/2020	SUPPLEMENT FOR EXPANSION	$6,707,769
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	12/6/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $8,227,340

Issue Date FY: 2019 ( Subtotal = $1,506,528 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	7/5/2019	NON-COMPETING CONTINUATION	$1,506,528
2019	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	5/2/2019	NEW	$0
														Subtotal = $1,506,528

Issue Date FY: 2018 ( Subtotal = $1,515,803 )
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	9/12/2018	NEW	$0
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/11/2018	NEW	$1,515,803
														Subtotal = $1,515,803

Grand Total All Awards = $18,508,052

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The Center for Innovation in Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern University (C-THAN)

Award Number: U54EB027049

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/11/2018

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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