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Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Tissue Mapping

Award Number: U54DK120058
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Tissue Mapping - Project Summary We propose the founding of the BIOmolecular Multimodal Imaging Center (BIOMIC) at Vanderbilt University as a Tissue Mapping Center associated with the Human BioMolecular Atlas Program (HuBMAP). The mission of BIOMIC is to build a platform of integrated technologies for imaging and molecular analysis that enables the construction of comprehensive 3-dimensional molecular atlases of human tissues. BIOMIC will leverage the unique resources of the Mass Spectrometry Research Center and the National Research Resource for Imaging Mass Spectrometry at Vanderbilt University along with the world-class clinical environment of the Vanderbilt University Medical Center to create a capability to characterize human tissues at a level of understanding unrivaled by current technologies. The innovative aspect of BIOMIC is the combination of 3-dimesional imaging mass spectrometry (IMS) with a variety of in vivo and ex vivo imaging technologies to create new modalities of molecularly-informed medical imaging. The application of the BIOMIC platform to organ-specific projects in kidney, pancreas, and bone will provide a new paradigm of understanding the normal state of these organs across multiple dimensions, both molecular (e.g., lipids, metabolites, and proteins) and spatial (e.g., whole organs to single cells). As a HuBMAP participant, the molecular atlases generated by BIOMIC will be disseminated to collaborators worldwide to facilitate the generation and testing of new hypotheses regarding the function of these important organ systems, enabling new insight into human health and disease. The mission of BIOMIC is to create a platform that can efficiently acquire and integrate multimodal imaging data sets, including IMS, histology, multiplex-IHC, magnetic resonance imaging, and high- resolution CT imaging for the formation of comprehensive 3-D molecular atlases. This effort requires the creation and integration of three capabilities to 1) procure and manage specimens, 2) prepare and mitigate pre-analytical factors, and 3) acquire, process, and disseminate multimodal imaging and large-scale omics data. The BIOMIC platform will be optimized and tested using three organ-specific projects: bone, kidney, and pancreas.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$235,630 )
2024	2021	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Trans-NIH Research Support	000	4	10/16/2023	NON-COMPETING CONTINUATION	-$235,630
														Subtotal = -$235,630

Issue Date FY: 2021 ( Subtotal = $1,991,795 )
2021	2021	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Trans-NIH Research Support	000	4	8/12/2021	NON-COMPETING CONTINUATION	$1,991,795
														Subtotal = $1,991,795

Issue Date FY: 2020 ( Subtotal = $2,100,000 )
2020	2020	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Trans-NIH Research Support	003	3	8/25/2020	SUPPLEMENT FOR EXPANSION	$100,000
2020	2020	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Trans-NIH Research Support	002	3	6/23/2020	NON-COMPETING CONTINUATION	$2,000,000
2020	2019	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Trans-NIH Research Support	001	2	6/18/2020	NON-COMPETING CONTINUATION	$0
2020	2019	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Trans-NIH Research Support	000	2	6/8/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,100,000

Issue Date FY: 2019 ( Subtotal = $1,196,155 )
2019	2019	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Trans-NIH Research Support	003	2	9/4/2019	SUPPLEMENT FOR EXPANSION	$96,645
2019	2019	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Trans-NIH Research Support	004	2	9/5/2019	NON-COMPETING CONTINUATION	$0
2019	2019	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Trans-NIH Research Support	002	2	7/30/2019	NON-COMPETING CONTINUATION	$1,000,000
2019	2019	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Trans-NIH Research Support	005	2	9/6/2019	SUPPLEMENT FOR EXPANSION	$99,510
2019	2018	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Trans-NIH Research Support	000	1	11/28/2018	NEW	$0
2019	2018	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Trans-NIH Research Support	001	1	1/8/2019	NEW	$0
														Subtotal = $1,196,155

Issue Date FY: 2018 ( Subtotal = $450,000 )
2018	2018	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Trans-NIH Research Support	000	1	9/19/2018	NEW	$450,000
														Subtotal = $450,000

Grand Total All Awards = $5,502,320

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Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Tissue Mapping

Award Number: U54DK120058

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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