Chronic kidney disease (CKD) including end stage renal disease (CKD stage 5) is a major health problem in
sub-Saharan Africa (SSA) affecting more than 50 million individuals but there is lamentable lack of research data
and there is no promise of urgently needed preventative strategies. The lack of data on CKD in SSA are in part
due to the absence of population-based epidemiologic studies of CKD and a scarcity of physician scientists
conducting genetic, clinical and translational research on CKD according to local priorities. Herein, we propose
to leverage the H3Africa Kidney Disease Research Network (H3A-KDRN) to (i) conduct genomics, clinical and
translational research on the most prevalent forms of CKD; (ii) expand and support a well-trained cadre of African
researchers and physician scientists to conduct CKD research according to regional priorities; (iii) engage SSA
communities and research participants in the initiation, governance, implementation and dissemination of CKD
research and (iv) foster collaboration with U.S.-based basic, clinical and translational researchers (including
Africans in the diaspora) to elucidate etiologies and mechanisms and discover effective therapeutic and
preventative strategies to combat the extraordinary burden of CKD in people of African ancestry globally The
H3A-KDRN is organized as a research consortium initially composed of: (a) 15 academic medical
centers/university teaching hospitals in five African countries- Cameroon - 1, Ghana – 4, Nigeria – 8, South Africa
- 1 and Tanzania – 1; (b) 9 North American/Israeli research intensive academic medical institutions; (c) 3 shared
cores – Training and Career Development, Data Management and Biostatistics and Genotyping Laboratories.
At the end of the five-year funding requested in this application, The H3AKDRN will have accomplished the
1. Completion of three research projects on: (i) CKD in HIV-infected patients; and (ii) childhood and adolescent
onset nephrotic syndrome and (iii) sickle cell disease nephropathy. These three prospective cohort studies
will have a total sample size of 5800 participants.
2. Completion of training of four African-based research scientists toward PhD (n=2) and MSc (n=1) in Clinical
and Translational Science (CTS) awarded by the University of Arizona
3. Completion of certificate training in clinical research methods for 45 African-based research personnel
4. Establish a high functioning regional Clinical and Translational Research Coordinating Center to support
multicenter research in CKD and other non-communicable chronic diseases in SSA.
With these foundational objectives, the H3Africa Kidney Disease Research Network will a transformative impact
on CKD research in SSA and thence move us closer to the goal of reducing the burden of CKD in the 352 million
Africans living in the five H3A-KDRN countries and in the 1.2 billion people of African descent globally.