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The Safety and Clinical Outcomes of Psychedelic Use (SCOPE) Center

Award Number: U54DA066461
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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The Safety and Clinical Outcomes of Psychedelic Use (SCOPE) Center - Project Summary: SCOPE Center Overall Proposal The Safety and Clinical Outcomes of Psychedelic Use (SCOPE) P50 Research Center builds a national resource to advance and share research on psychedelic safety and health outcomes in real-world settings. Early clinical trials showed promise for psychedelic medications to relieve depression, anxiety, PTSD, and substance use disorders. Media coverage helped drive public opinion to approve voter referenda in Oregon and Colorado, and legislation in New Mexico establishing legal frameworks for psychedelic services. Yet the real-world safety and outcomes of expanding psychedelic use remain unknown. The SCOPE Center provides coordinated, multifaceted tools that surpass the reach of individual studies. The Center a) conducts integrated research on safety and health outcomes of state- regulated and unregulated use (e.g., trajectories of use, outcomes across the life course, and policy impacts), and b) creates a national repository of coordinated datasets with harmonized measures and tools accessible to researchers inside and outside the Center. The SCOPE Center integrates three cores (Administrative Core, Research-Data Core, Pilot-Mentorship Core) and two advisory bodies. The Administrative Core provides organizational and fiscal oversight, consortium coordination, and dissemination. The Research-Data Core offers methodological guidance, harmonized data coordination, statistical support, and pilot data. The Pilot-Mentorship Core’s pilot awards test innovative hypotheses using Center data sources. The Center’s National Scientific Consortium of psychedelic scientists and the Community Advisory Council of practitioners, facilitators, and stakeholders guide Center priorities and ensure relevance. These structures support three synergistic research projects. The Open Psychedelic Evaluation Network (OPEN; Project 1) compares safety and outcomes of clients in state-regulated services with people using psychedelics in unregulated settings. The Psychedelic STudy of Age Groups Examining Subject outcomes study (PsychSTAGES; Project 2) examines outcomes of unregulated use across adolescents/young adults (15–24), adults (18–49), and older adults (≥50). The Simulated Psilocybin Models And Emulated Trials for Consequences and Effectiveness study (SPACE; Project 3) uses emulated target trials and simulation models to predict health and policy outcomes. Together, the research projects generate a mosaic of real-world data that a national psychedelic research community can use to inform policy and the public. The SCOPE Center triangulates results across projects, convenes a national community of researchers and stakeholders, and disseminates findings widely to ensure that policy and clinical decisions about psychedelic services rest on rigorous, trustworthy, real-world evidence.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,398,570 )
2026	2026	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Use and Addiction Research Programs	000	1	9/2/2026	NEW	$1,398,570
														Subtotal = $1,398,570

Grand Total All Awards = $1,398,570

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The Safety and Clinical Outcomes of Psychedelic Use (SCOPE) Center

Award Number: U54DA066461

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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