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Data Center for Acute to Chronic Pain Biosignatures

Award Number: U54DA049110
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2019
PERIOD OF PERFORMANCE END DATE: 07/31/2027

Group Awards By:

View Award Description

Data Center for Acute to Chronic Pain Biosignatures - Understanding the mechanisms underlying the transition to chronic pain is a key to mitigating the dual epidemics of chronic pain and opioid use in the U.S. In response to RFA-RM-18-031, and as part of the NIH Common Fund Acute to Chronic Pain Signatures (A2CPS) Program, we will establish a Data Integration and Resource Center (DIRC) to integrate imaging, physiology, -omics, behavioral, and clinical data to develop biosignatures for the transition to chronic pain. The Center will be based in the Department of Biostatistics at JHU, a nexus for a wide range of collaborators with expertise in (1) advanced data science and machine learning, (2) neuroimaging, (3) genomics and related -omics, (4) wearable computing and smartphone-based behavioral assessment, (5) systems-level predictive biosignatures, (6) software engineering and high-performance computing, and (7) world-renowned pain researchers from JHU and other institutions. JHU Biostatistics is the top-ranked department of its kind in the country, and its unique blend of faculty provides the ability to be nimble and accommodate analysis of diverse data types as needed, and a unique capacity for scientific outreach through online courses and other forums. To deliver computing infrastructure and cloud-based computing for A2CPS, we partner with the Texas Advanced Computing Center (TACC), who have a long track record of large-scale collaborations and have already built many of the cloud computing tools we see as ideal for this project. The Center will consist of three components and an Administrative Core. The Administrative Core will lead the Center and facilitate interaction among the components of the Center and across the A2CPS consortium. The Data Coordination Component (DCC) will provide the infrastructure for storage and processing, analysis pipelines, cloud computing, and portals for data upload/query/export, in addition to other technical deliverables. The Data Integration and Analysis Component (DIAC) will provide data type-specific content for pipelines and analyses of data collected by the A2CPS consortium. The Scientific Outreach Component (SOC) will use DCC- developed portal infrastructure to maintain the consortium intranet and perform outreach via the public A2CPS portal. It will also organize a variety of in-person and online training and outreach programs, including the creation of free, online courses disseminating information about chronic pain and A2CPS tools, data, and models.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $567,455 )
2026	2026	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	000	8	8/4/2026	NON-COMPETING CONTINUATION	$487,455
2026	2026	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Common Fund	001	8	8/14/2026	SUPPLEMENT FOR EXPANSION	$80,000
2026	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	002	7	8/26/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $567,455

Issue Date FY: 2025 ( Subtotal = $1,676,111 )
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	002	7	8/1/2025	NON-COMPETING CONTINUATION	$979,755
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	003	7	8/22/2025	SUPPLEMENT FOR EXPANSION	$696,356
2025	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	001	6	7/30/2025	NON-COMPETING CONTINUATION	$0
2025	2023	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	000	5	10/10/2024	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $1,676,111

Issue Date FY: 2024 ( Subtotal = $1,279,316 )
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	004	6	8/9/2024	NON-COMPETING CONTINUATION	$1,279,316
2024	2023	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	003	5	2/23/2024	EXTENSION WITH OR WITHOUT FUNDS	$3,854,147
2024	2023	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	000	5	1/8/2024	EXTENSION WITH OR WITHOUT FUNDS	$0
2024	2022	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	001	4	2/23/2024	NON-COMPETING CONTINUATION	-$2,534,841
2024	2022	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	002	4	2/23/2024	SUPPLEMENT FOR EXPANSION	-$1,319,306
														Subtotal = $1,279,316

Issue Date FY: 2023 ( Subtotal = $679,094 )
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	001	5	9/19/2023	SUPPLEMENT FOR EXPANSION	$79,093
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	000	5	8/7/2023	EXTENSION WITH OR WITHOUT FUNDS	$600,001
														Subtotal = $679,094

Issue Date FY: 2022 ( Subtotal = $4,534,841 )
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	000	4	8/15/2022	NON-COMPETING CONTINUATION	$2,534,841
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	001	4	8/17/2022	SUPPLEMENT FOR EXPANSION	$2,000,000
														Subtotal = $4,534,841

Issue Date FY: 2021 ( Subtotal = $2,558,249 )
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	002	3	8/11/2021	NON-COMPETING CONTINUATION	$2,558,249
2021	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	001	2	4/14/2021	NON-COMPETING CONTINUATION	$0
2021	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	000	2	2/8/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,558,249

Issue Date FY: 2020 ( Subtotal = $2,582,997 )
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	000	2	8/24/2020	NON-COMPETING CONTINUATION	$2,582,997
														Subtotal = $2,582,997

Issue Date FY: 2019 ( Subtotal = $299,586 )
2019	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	000	1	8/20/2019	NEW	$299,586
														Subtotal = $299,586

Grand Total All Awards = $14,177,649

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Data Center for Acute to Chronic Pain Biosignatures

Award Number: U54DA049110

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2019

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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