Friday, May 16, 2025 5/16/2025

Chicago Prevention and Intervention Epicenter II (CPIE-II)

Award Number: U54CK000481
ORGANIZATION: NATIONAL CENTER FOR ZOONOTIC, VECTOR-BORNE, AND ENTERIC DISEASES
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

Chicago Prevention and Intervention Epicenter II (CPIE-II) - C-PIE II ABSTRACT Multidrug-resistant organisms (MDROs) are increasingly common causes of healthcare-associated infections (HAIs), complicating treatment and leading to increased morbidity, mortality and cost. The Chicago Prevention and Epicenter II (C-PIE II) has developed a portfolio of research projects to study the epidemiology and prevention of key HAI problems, i.e. those caused by MDROs, from the level of individual intensive care units to entire healthcare facilities (long-term acute care hospitals) to the region (Chicago, the third largest city in the nation) and to the state (Illinois, population 13 million). Our proposals range from investigations to improve basic infection control interventions that we have pioneered, such as chlorhexidine gluconate (CHG) bathing, to research that employs the most advanced molecular diagnostic techniques, e.g. bacterial whole genome sequencing and microbiome analysis, and cutting-edge informatics and analytic methods, such as automated alerts and social network analysis. We will conduct our work within a sophisticated existing infrastructure of strong collaborative public health and academic partnerships. These proposed activities comprise our Core Project and Multicenter Collaborative Project proposals. Core Project: We will continue to evaluate novel methods to study the epidemiology and control of carbapenem-resistant Enterobacteriaceae, to optimize antimicrobial stewardship interventions through ethnographic evaluation, and to assess the effect of alternative nasal decolonization strategies on the susceptibility of methicillin-resistant Staphylococcus aureus to antibiotics and antiseptics. The likelihood of success of our investigations is increased by our plan to use a coordinated, collaborative approach across many healthcare facility types, public health agencies, and academic institutions. Multicenter Projects: We propose a Large-sized Collaborative Project (MAriMbA) that will test the hypothesis that specific host factors, clinical care exposures, and gut microbiota alterations are associated with an increased risk of colonization by enteric MDROs. We propose a Medium-sized Collaborative Project (DataMAP-AU) to promote an infrastructure that can be expanded nationally to facilitate and standardize antimicrobial use metrics that are most informative for antimicrobial stewardship interventions. We propose a Small Collaborative Project (CHECkuP) to better understand the optimal use of CHG skin antisepsis to reduce patient colonization by MDROs. In total, we expect our work to fill critical gaps in knowledge related to the epidemiology and prevention of HAIs caused by MDROs, and to advance the science of infection prevention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$268 )
2023	2020	RUSH UNIVERSITY MEDICAL CENTER	1620 W Harrison St	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	07	5	12/30/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2019	RUSH UNIVERSITY MEDICAL CENTER	1620 W Harrison St	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	06	5	12/16/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	-$268
2023	2019	RUSH UNIVERSITY MEDICAL CENTER	1620 W Harrison St	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	07	5	12/30/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2018	RUSH UNIVERSITY MEDICAL CENTER	1620 W Harrison St	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	07	5	12/30/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2017	RUSH UNIVERSITY MEDICAL CENTER	1620 W Harrison St	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	07	5	12/30/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2016	RUSH UNIVERSITY MEDICAL CENTER	1620 W Harrison St	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	07	5	12/30/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = -$268

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	05	5	10/6/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2019	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	05	5	10/6/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2018	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	05	5	10/6/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2017	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	05	5	10/6/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2016	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	05	5	10/6/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	04	5	12/16/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2021	2019	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	04	5	12/16/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $600,000 )
2020	2020	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	03	5	6/15/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2020	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	02	5	6/11/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$600,000
2020	2019	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	01	5	11/8/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2019	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	02	5	6/11/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2019	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	03	5	6/15/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $600,000

Issue Date FY: 2019 ( Subtotal = $515,436 )
2019	2019	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	00	5	5/30/2019	NON-COMPETING CONTINUATION	$515,436
2019	2018	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	01	4	1/25/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2017	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	01	4	1/25/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2016	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	01	4	1/25/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $515,436

Issue Date FY: 2018 ( Subtotal = $661,534 )
2018	2018	Rush University Medical Center	1653 W Congress Prkwy	Chicago	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	00	4	6/26/2018	NON-COMPETING CONTINUATION	$661,534
														Subtotal = $661,534

Issue Date FY: 2017 ( Subtotal = $498,788 )
2017	2017	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	001	3	9/22/2017	NON-COMPETING CONTINUATION	$0
2017	2017	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	000	3	6/8/2017	NON-COMPETING CONTINUATION	$498,788
														Subtotal = $498,788

Issue Date FY: 2016 ( Subtotal = $5,197,622 )
2016	2016	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	002	2	8/25/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$5,197,622
2016	2016	HEKTOEN INSTITUTE FOR MEDICAL RESEARCH	2100 WEST HARRISON ST, 2ND FL	CHICAGO	IL	606129982	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	006	1	9/16/2016	NEW	$0
2016	2016	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	005	2	9/14/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$5,197,622
2016	2016	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	004	2	9/14/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$5,197,622
2016	2016	HEKTOEN INSTITUTE FOR MEDICAL RESEARCH	2100 WEST HARRISON ST, 2ND FL	CHICAGO	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	001	1	8/23/2016	NEW	-$5,197,622
2016	2016	RUSH UNIVERSITY MEDICAL CENTER	1653 WEST CONGRESS WAY	CHICAGO	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	003	2	9/9/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2016	2016	HEKTOEN INSTITUTE FOR MEDICAL RESEARCH	2100 WEST HARRISON ST, 2ND FL	CHICAGO	IL	60612	COOK	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	000	1	6/27/2016	NEW	$5,197,622
														Subtotal = $5,197,622

Grand Total All Awards = $7,473,112

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Chicago Prevention and Intervention Epicenter II (CPIE-II)

Award Number: U54CK000481

ORGANIZATION: NATIONAL CENTER FOR ZOONOTIC, VECTOR-BORNE, AND ENTERIC DISEASES

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer