Wednesday, January 15, 2025 1/15/2025

United States-East Africa HIV-Associated Malignancy Research Center (USEAHAMRC) for Career Development and the Prevention, Early Detection and Efficient Linkage to Care for Virus-related Cancers

Award Number: U54CA254571
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 23-038. Women in sub-Saharan Africa bear the greatest burden of cervical cancer in the world, and the reasons are clear: lack of HPV vaccination, screening for pre-cancer, and treatment. In recognition of the global disparities surrounding cervical cancer and that preventive solutions exist, the WHO has adopted a global strategy for cervical cancer elimination. It calls for 90% vaccination coverage, 70% screening coverage, and treatment of 90% of those with cervical disease. Lacking in this strategy, however, is a clear path to implementation. Furthermore, a shortage in the research workforce in areas most affected, such as sub-Saharan Africa, hinders the ability for context-specific evidence to be generated to reduce the disparities. Through parent award U54 CA254571, we have developed in East Africa what we call a campaign-based public health approach to address gaps in the implementation of preventive interventions for cervical cancer control. Our approach features Community Health Worker-led mobilization of eligible community members to attend local Health Fairs at which HPV vaccination and HPV-based cervical cancer screening (via self- collection) are offered, followed by ablative therapy for those found to be HPV-infected by a Mobile Treatment Team at a convenient central site in the community. In Kenya and Uganda, these community-based campaigns have been well-attended and well-accepted. NOT-CA-23-038 is a well-timed opportunity for us to expand our work in East Africa to another resource-limited socio-geographic context — Liberia, in West Africa — while concurrently providing a research practicum for an early-stage low- and middle-income country (LMIC) investigator (ESLI) from Liberia. Accordingly, our specific aims are to: Aim 1: Evaluate the uptake and acceptability of HPV vaccination and cervical cancer screening offered through a campaign-based public health approach to cervical cancer control in Liberia. Aim 2: Determine the factors explaining non-participation in either community-based HPV vaccination among adolescent girls or in cervical cancer screening among women in Liberia. Aim 3: Provide a mentored career development experience for Dr. Cozie Gwaikolo, a Liberian ESLI. To address our aims, we will evaluate a community-based integrated cervical cancer vaccination and screening program (developed in parent grant U54 CA254571), which will be implemented by our Ministry of Health (MOH) partners in Liberia. Evaluation will include assessment of acceptability and follow-up among Health Fair attendees as well as a population-based door-to-door community survey after completion of the campaign, which will determine uptake of the program and reasons for non-participation. Findings from this work may form a blueprint for the ultimate elimination of cervical cancer in the region. Finally, the project is an incomparable opportunity for Dr. Gwaikolo in his quest to become an independent principal investigator.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,063,493 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	5	6/11/2024	NON-COMPETING CONTINUATION	$1,063,493
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	4	1/12/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,063,493

Issue Date FY: 2023 ( Subtotal = $1,277,830 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	4	6/13/2023	NON-COMPETING CONTINUATION	$950,999
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	002	4	9/18/2023	SUPPLEMENT FOR EXPANSION	$124,481
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	4	8/30/2023	SUPPLEMENT FOR EXPANSION	$202,350
														Subtotal = $1,277,830

Issue Date FY: 2022 ( Subtotal = $255,057 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	3	7/20/2022	NON-COMPETING CONTINUATION	$255,057
														Subtotal = $255,057

Issue Date FY: 2021 ( Subtotal = $1,199,217 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	2	9/17/2021	SUPPLEMENT FOR EXPANSION	$198,085
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	2	7/21/2021	NON-COMPETING CONTINUATION	$1,001,132
														Subtotal = $1,199,217

Issue Date FY: 2020 ( Subtotal = $1,054,123 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	1	7/21/2020	NEW	$0
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	1	7/13/2020	NEW	$1,054,123
														Subtotal = $1,054,123

Grand Total All Awards = $4,849,720

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United States-East Africa HIV-Associated Malignancy Research Center (USEAHAMRC) for Career Development and the Prevention, Early Detection and Efficient Linkage to Care for Virus-related Cancers

Award Number: U54CA254571

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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