Monday, October 27, 2025 10/27/2025

United States-East Africa HIV-Associated Malignancy Research Center (USEAHAMRC) for Career Development and the Prevention, Early Detection and Efficient Linkage to Care for Virus-related Cancers

Award Number: U54CA254571
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/13/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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United States-East Africa HIV-Associated Malignancy Research Center (USEAHAMRC) for Career Development and the Prevention, Early Detection and Efficient Linkage to Care for Virus-related Cancers - In the field of HIV-associated malignancies, East Africa faces three intersecting problems common to resource-limited settings. First, East Africa lacks effective primary and secondary prevention strategies for cervical cancer and Kaposi’s sarcoma (KS), two of the most common cancers not only among HIV-infected persons but in the general population. Survival for both malignancies is poor due to multiple factors including lack of screening, advanced disease stage at presentation, suboptimal diagnostic tests and fragile linkage to care. Second, there is a paucity of local principal investigators to lead research related to HIV- associated cancer. Third, there are no robust research networks to study primary and secondary prevention of HIV-associated cancers in the region. To address this, eight institutions in the U.S. and East Africa will: Aim 1. Create a collaborative network of U.S.-based and East African-based scientists and institutions — the United States-East Africa HIV-Associated Malignancy Research Center (USEAHAMRC) — focused on career development and the performance of research related to prevention, early detection and efficient linkage to care for virus-related cancers; Aim 2. Support the career development of emerging African principal investigators, U.S.-based junior investigators and others in the USEAHAMRC in the performance of HIV and other virus- related cancer research; and Aim 3. Conduct novel research — led by our emerging African principal investigators — related to the prevention, early detection and efficient linkage to care for virus-related cancers. The USEAHAMRC will build on prior work in U54 CA190153 to create a network of scientists from 4 U.S. institutions (UCSF, Duke, Massachusetts General Hospital, and the National Library of Medicine) and 4 African institutions in 3 East African countries (Infectious Diseases Institute in Uganda; Moi University in Kenya; Kenya Medical Research Institute; and Muhimbili University in Tanzania) (Aim 1). We will model our career development activities after NIH-sponsored institutional mentored career development programs (Aim 2). Managed by a Developmental Core, these activities will include professional enrichment to all interested junior scientists at our participating institutions, mentoring of a select group of African and U.S.- based junior scientists to compete for career development awards, and a Pilot Project program to attract new junior scientists. Our African junior investigators will also lead two research projects (Aim 3): Project 1, A Public Health Approach to Cervical Cancer Prevention in East Africa; and Project 2, Rapid Case Ascertainment as a Tool for Epidemiologic Investigation and Efficient Linkage to Care in HIV-infected Patients Diagnosed with Kaposi Sarcoma in East Africa. A Data Management and Biostatistical Analysis Core (DMBAC) will support all of the science. Finally, an Administrative Core will oversee all operations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $797,359 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	005	6	9/18/2025	SUPPLEMENT FOR EXPANSION	$190,517
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	003	6	9/18/2025	SUPPLEMENT FOR EXPANSION	$23,375
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	6	9/17/2025	NON-COMPETING CONTINUATION	$560,167
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	004	6	9/18/2025	SUPPLEMENT FOR EXPANSION	$10,800
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	002	6	9/18/2025	SUPPLEMENT FOR EXPANSION	$12,500
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	5	3/28/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $797,359

Issue Date FY: 2024 ( Subtotal = $1,063,493 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	5	6/11/2024	NON-COMPETING CONTINUATION	$1,063,493
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	4	1/12/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,063,493

Issue Date FY: 2023 ( Subtotal = $1,277,830 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	002	4	9/18/2023	SUPPLEMENT FOR EXPANSION	$124,481
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	4	8/30/2023	SUPPLEMENT FOR EXPANSION	$202,350
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	4	6/13/2023	NON-COMPETING CONTINUATION	$950,999
														Subtotal = $1,277,830

Issue Date FY: 2022 ( Subtotal = $255,057 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	3	7/20/2022	NON-COMPETING CONTINUATION	$255,057
														Subtotal = $255,057

Issue Date FY: 2021 ( Subtotal = $1,199,217 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	2	7/21/2021	NON-COMPETING CONTINUATION	$1,001,132
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	2	9/17/2021	SUPPLEMENT FOR EXPANSION	$198,085
														Subtotal = $1,199,217

Issue Date FY: 2020 ( Subtotal = $1,054,123 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	1	7/21/2020	NEW	$0
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	1	7/13/2020	NEW	$1,054,123
														Subtotal = $1,054,123

Grand Total All Awards = $5,647,079

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United States-East Africa HIV-Associated Malignancy Research Center (USEAHAMRC) for Career Development and the Prevention, Early Detection and Efficient Linkage to Care for Virus-related Cancers

Award Number: U54CA254571

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/13/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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