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Einstein/Rwanda/DRC Consortium for Research in HIV/HPV/Malignancies

Award Number: U54CA254568
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Einstein/Rwanda/DRC Consortium for Research in HIV/HPV/Malignancies - As millions of Africans living with HIV (LWH) live longer due to effective antiretroviral therapy (ART), their incidence of diseases of aging, including cancer, is increasing. Human papillomavirus (HPV) is the causal agent for almost all cervical and anal cancers, and ~50% of head and neck cancers. Cervical cancer, an AlDS- defining malignancy, is a leading cause of cancer deaths in women worldwide. The transforming capability of HPV is enhanced in women LWH (WLWH), whose HPV-related cervical lesions are more prevalent, more likely to progress, and more likely to become cancer. HPV also causes transformation of the anal mucosa. Men who have sex with men (MSM) constitute a substantial proportion of persons living with HIV (PLWH) around the world, and the incidence of HPV-related anal cancer is growing among MSM living with HIV. The incidence of cervical and anal cancers has not declined with the introduction of ART and remains elevated several fold in women and men LWH. We propose to establish an HIV-Associated HPV-related Malignancies Research Center (HAMRC) in Rwanda and the Democratic Republic of Congo (DRC), a partnership of four institutions: Albert Einstein College of Medicine, the University of Rwanda (UR), Rwanda Military Hospital (major teaching hospital for UR), and Université Protestante au Congo (UPC), to investigate HIV/HPV related cancers in Africa. This is an extension of our current U54-funded Rwanda/Einstein Research Consortium for HIV/HPV Malignancies, which has been highly successful in performing high-value rigorous research and developing laboratory and investigator research capacity. We will build upon and strengthen our existing partnerships to create a dynamic, integrated and flexible platform with academic, clinical and administrative expertise to support and foster the growth of scientific knowledge in HPV-related cancers in PLWH. We propose two research projects to be conducted over five years that can quickly impact the prevention of HIV/HPV cancers by supporting evidence-based decision-making to improve health outcomes: 1.) population based effectiveness of HPV vaccination in Rwandan women; and 2.) HPV prevalence and disease burden in men who have sex with men (MSM) in DRC and Rwanda. Embedded in both of these projects will be studies of the interaction of the local microbial flora with cervicovaginal, anal, and penile HPV infection. We propose to support both projects by developing laboratory capacity in molecular diagnostics in DRC, and in next generation sequencing (NGS) in Rwanda. Leadership will be provided by a team of four multiple principal investigators (MPIs): Kathryn Anastos MD, Leon Mutesa MD PhD, Marcel Yotebieng MD PhD, and Philip Castle PhD MPH, bringing strong experience in each or our three countries, Rwanda, DRC and the United States. Our Center, a collaboration of US, Rwandan and DRC institutions will serve as a national and regional resource hub in research, training, and career development for African scientific leaders in HIV/HPV-related cancers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$12,976 )
2026	2024	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	000	5	11/21/2025	NON-COMPETING CONTINUATION	-$12,976
														Subtotal = -$12,976

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	000	5	11/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,100,145 )
2024	2024	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	002	5	7/8/2024	NON-COMPETING CONTINUATION	$124,200
2024	2024	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	001	5	6/4/2024	NON-COMPETING CONTINUATION	$37,205
2024	2024	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	000	5	5/31/2024	NON-COMPETING CONTINUATION	$938,740
														Subtotal = $1,100,145

Issue Date FY: 2023 ( Subtotal = $1,120,233 )
2023	2023	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	002	4	9/15/2023	NON-COMPETING CONTINUATION	$133,995
2023	2023	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	001	4	5/31/2023	NON-COMPETING CONTINUATION	$986,238
2023	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	000	3	3/20/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,120,233

Issue Date FY: 2022 ( Subtotal = $963,221 )
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	001	3	6/28/2022	NON-COMPETING CONTINUATION	$963,221
2022	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	000	2	12/22/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $963,221

Issue Date FY: 2021 ( Subtotal = $966,003 )
2021	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	000	2	5/27/2021	NON-COMPETING CONTINUATION	$966,003
														Subtotal = $966,003

Issue Date FY: 2020 ( Subtotal = $988,290 )
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	000	1	9/21/2020	NEW	$988,290
														Subtotal = $988,290

Grand Total All Awards = $5,124,916

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Einstein/Rwanda/DRC Consortium for Research in HIV/HPV/Malignancies

Award Number: U54CA254568

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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