Wednesday, July 16, 2025 7/16/2025

Systems biology of the tumor immune microenvironment

Award Number: U54CA209975
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2022

Group Awards By:

View Award Description

Systems biology of the tumor immune microenvironment - Systems biology of the tumor immune microenvironment Project Summary- Research activities proposed for the extension year will exploit syngeneic murine cancer models established with U54 funding (Projects 1, 3) and recent single cell epigenetic/multiomic and spatial transcriptomic technologies deployed at our Center (Projects 1, 2, Shared Resource Core), enabling experimental and computational modeling of tumor-immune interactions with high fidelity to human tumor biology and at rich single cell and spatial resolution. Below we outline six major activities for the extension year, each led by a Center investigator and contributing to the original specific aims of our U54 proposal. 1. Modeling T cell, stromal, and cancer cell co-evolution in melanoma (Project 1). 2. Learning gene regulatory programs governing tumor-associated T cell states (Project 1). 3. Spatial analyses of Treg cell-mediated cellular communications in the lung adenocarcinoma microenvironment (Project 2). 4. Immune surveillance of metastasis in a syngeneic murine lung adenocarcinoma model (Project 3). 5. Tissue mimetic modeling of the response of metastatic lineages to nutrient gradients (Project 3). 6. Computational integration of single cell RNA and ATAC sequencing data (Shared Resource Core). .


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$156,126 )
2023	2021	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVENUE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	5	4/7/2023	SUPPLEMENT FOR EXPANSION	-$156,126
														Subtotal = -$156,126

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	004	5	5/13/2022	SUPPLEMENT FOR EXPANSION	$330,912
2022	2021	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	002	5	5/6/2022	SUPPLEMENT FOR EXPANSION	-$330,912
2022	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	003	5	5/13/2022	NON-COMPETING CONTINUATION	$112,910
2022	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	5	11/22/2021	NON-COMPETING CONTINUATION	$0
2022	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	001	5	5/6/2022	NON-COMPETING CONTINUATION	-$112,910
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $330,912 )
2021	2021	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	5	7/6/2021	SUPPLEMENT FOR EXPANSION	$330,912
														Subtotal = $330,912

Issue Date FY: 2020 ( Subtotal = $2,312,460 )
2020	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	001	5	7/31/2020	NON-COMPETING CONTINUATION	$2,312,460
2020	2019	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	4	7/30/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,312,460

Issue Date FY: 2019 ( Subtotal = $2,296,097 )
2019	2019	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	4	7/19/2019	NON-COMPETING CONTINUATION	$2,296,097
														Subtotal = $2,296,097

Issue Date FY: 2018 ( Subtotal = $2,409,446 )
2018	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	001	3	7/27/2018	NON-COMPETING CONTINUATION	$171,700
2018	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	002	3	8/13/2018	NON-COMPETING CONTINUATION	$140,229
2018	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	3	7/11/2018	NON-COMPETING CONTINUATION	$2,097,517
														Subtotal = $2,409,446

Issue Date FY: 2017 ( Subtotal = $2,187,373 )
2017	2017	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	001	2	8/29/2017	NON-COMPETING CONTINUATION	$89,856
2017	2017	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	2	7/31/2017	NON-COMPETING CONTINUATION	$2,097,517
														Subtotal = $2,187,373

Issue Date FY: 2016 ( Subtotal = $2,290,451 )
2016	2016	SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVENUE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	1	8/26/2016	NEW	$2,119,051
2016	2016	SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVENUE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	001	1	9/2/2016	SUPPLEMENT FOR EXPANSION	$171,400
														Subtotal = $2,290,451

Grand Total All Awards = $11,670,613

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Systems biology of the tumor immune microenvironment

Award Number: U54CA209975

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2022

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer