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SARC Sarcoma SPORE

Award Number: U54CA168512
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/26/2012
PERIOD OF PERFORMANCE END DATE: 08/31/2018

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SARC Sarcoma SPORE - DESCRIPTION (provided by applicant): This application represents unprecedented cooperation among excellent institutions, major sarcoma dedicated non-profit organizations, and the NCI intramural Program. This SPORE originates from SARC, a non-for-profit consortium that facilitates the conduct of research among national centers of excellence in sarcoma. The main goals of the SARC Sarcoma SPORE are the translation of biological and technological advances into improvements in prevention, diagnostics, predictors of outcome, and - particularly - advances in the treatment of sarcoma. The SARC Sarcoma SPORE is anchored by multiple researchers from SARC, Harvard, MD Anderson Cancer Center, and the NCI intramural program, but also includes key individual researchers from Stanford University, Columbia University and The University of Michigan. The researchers represent medical and pediatric oncology and the projects explore both soft tissue and bone sarcomas. Four major projects are proposed: 1) HDACi-based therapeutic strategies for the treatment of genetically complex STS; 2) Identification of therapeutic windows for NFI-related malignant peripheral nerve sheath tumor; 3) Investigation of G-protein coupled receptors as biomarkers of aggressive disease and novel therapeutic targets in Ewing sarcoma; and 4) Development of quantitative imaging biomarkers for assessing therapeutic response to sarcoma therapy using advanced approaches in PET and MRl. These projects are integrated and supported by 4 cores: 1) Administration, Evaluation and Planning; 2) Tissue and Pathology; 3) Clinical Trials; and 4) Biostatistics. The SPORE application outlines a Developmental Research Program that includes a plan for selection of new projects as well as 14 proposed developmental pilot projects. We also include a Career Developmental Program that outlines a mechanism for the identification and support of talented young investigators in translational or clinical sarcoma research. The projects, cores and programs are highly integrated and are poised to take maximum advantage of the SPORE mechanism to achieve translational goals. This SPORE joins state-of-the-art research projects with the multi-institution, collaborative strength of SARC and commitments from leading institutions to produce translational advances.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = -$1 )
2019	2016	SARC	24 FRANK LLOYD WRIGHT DR STE A3100	ANN ARBOR	MI	48105	WASHTENAW	USA	Cancer Centers Support Grants	000	5	2/14/2019	SUPPLEMENT FOR EXPANSION	-$1
														Subtotal = -$1

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	SARC	24 FRANK LLOYD WRIGHT DR STE A3100	ANN ARBOR	MI	48105	WASHTENAW	USA	Cancer Centers Support Grants	001	5	1/24/2017	EXTENSION WITH OR WITHOUT FUNDS	$17,129
2017	2015	SARC	24 FRANK LLOYD WRIGHT DR STE A3100	ANN ARBOR	MI	48105	WASHTENAW	USA	Cancer Centers Support Grants	000	4	1/24/2017	NON-COMPETING CONTINUATION	-$17,129
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $2,209,691 )
2016	2016	SARC INC	110 MILLER	ANN ARBOR	MI	48104	WASHTENAW	USA	Cancer Centers Support Grants	000	5	8/23/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,161,999
2016	2016	SARC INC	110 MILLER	ANN ARBOR	MI	48104	WASHTENAW	USA	Cancer Centers Support Grants	001	5	8/29/2016	SUPPLEMENT FOR EXPANSION	$47,692
														Subtotal = $2,209,691

Issue Date FY: 2015 ( Subtotal = $2,185,000 )
2015	2015	SARC INC	110 MILLER	ANN ARBOR	MI	48104	WASHTENAW	USA	Cancer Centers Support Grants	000	4	8/26/2015	NON-COMPETING CONTINUATION	$2,185,000
														Subtotal = $2,185,000

Issue Date FY: 2014 ( Subtotal = $2,162,001 )
2014	2014	SARC INC	110 MILLER	ANN ARBOR	MI	48104	WASHTENAW	USA	Cancer Centers Support Grants	000	3	9/15/2014	NON-COMPETING CONTINUATION	$2,162,001
														Subtotal = $2,162,001

Issue Date FY: 2013 ( Subtotal = $2,150,500 )
2013	2013	SARC INC	110 MILLER	ANN ARBOR	MI	48104	WASHTENAW	USA	Cancer Centers Support Grants	002	2	8/22/2013	NON-COMPETING CONTINUATION	$2,150,500
2013	2012	SARC INC	110 MILLER	ANN ARBOR	MI	48104	WASHTENAW	USA	Cancer Centers Support Grants	001	1	2/8/2013	NEW	$0
2013	2012	SARC INC	110 MILLER	ANN ARBOR	MI	48104	WASHTENAW	USA	Cancer Centers Support Grants	000	1	10/18/2012	NEW	$0
														Subtotal = $2,150,500

Issue Date FY: 2012 ( Subtotal = $2,300,000 )
2012	2012	SARC INC	110 MILLER	ANN ARBOR	MI	48104	WASHTENAW	USA	Cancer Centers Support Grants	000	1	9/26/2012	NEW	$2,300,000
2012	2012	SARC INC	110 MILLER	ANN ARBOR	MI	48104	WASHTENAW	USA	Cancer Centers Support Grants	001	1	10/18/2012	NEW	$0
														Subtotal = $2,300,000

Grand Total All Awards = $11,007,191

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SARC Sarcoma SPORE

Award Number: U54CA168512

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/26/2012

PERIOD OF PERFORMANCE END DATE: 08/31/2018

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