Wednesday, October 9, 2024 10/9/2024

Disparities in breast cancer treatment using Granulocyte colony-stimulating factors and CDK4/6 inhibitors between African and European ancestry individuals in two large Electronic Health Records

Award Number: U54CA163072
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY: OVERALL Cancer health disparities based on factors such as race and ethnicity are the result of a combination of socioeconomic, environmental, behavioral, and biological factors. These disparities impact cancer incidence, prevalence, mortality, survivorship, financial burden, and screening rates. The long-standing and mature Meharry Medical College (MMC), Vanderbilt-Ingram Cancer Center (VICC), Tennessee State University (TSU) Cancer Partnership (MVTCP), continues to provide and expand upon an exceptional cancer research and training environment to support the efforts of diverse investigators in addressing disparities. These efforts span across multiple disciplines to study the determinants of cancer health disparities at an NCI-designated comprehensive cancer center (VICC) along with enhancing research infrastructure, capacity-building, and impact at two minority- serving institutions (MMC and TSU). Collectively, over the past twenty years of partnership, these collaborative efforts provide a robust infrastructure to address and overcome cancer disparities while expanding research opportunities, recruitment and training. Our Triad has benefited from sustained and strong collaborative interactions between the three partner institutions, resulting in robust community and educational outcomes. Moreover, the geographical placement of this Triad in Tennessee, a region with some of the highest cancer incidence and mortality rates in the United States, also provides a unique opportunity for our Partnership to positively impact outcomes for cancer patients in this geographical region. This region continues to have significant cancer health disparities in lung, breast, prostate, and colorectal cancers. In order to meet our ultimate goals of overcoming cancer disparities while simultaneously strengthening research impact, the overall objectives of this competing renewal application are to: 1) increase the participation in traditional, investigator- initiated cancer research projects awarded to MMC and TSU faculty with collaborative guidance by senior VICC faculty; 2) increase the number of investigator-initiated awards to VICC junior faculty that address cancer disparities; 3) recruit, train and retain early-stage investigators to become independent leaders in cancer health disparities and cancer research and training; 4) expand MVTCP participation in national oncology treatment and interventional trials; 5) strengthen the physical and intellectual infrastructure for research at MMC and TSU; 6) facilitate partnerships between community organizations and academic researchers, leading to hypothesis- driven research projects that include the involvement of a community health educator; 7) increase the number of MMC and TSU trainees engaged in cancer research; and 8) increase awareness of cancer research opportunities and careers for minority high school, undergraduate, graduate and medical students through the Pathway to Discovery program.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,707,811 )
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	003	15	9/25/2024	NON-COMPETING CONTINUATION	$112,244
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	001	15	8/30/2024	NON-COMPETING CONTINUATION	$1,395,567
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	002	15	9/9/2024	SUPPLEMENT FOR EXPANSION	$200,000
2024	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	14	3/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,707,811

Issue Date FY: 2023 ( Subtotal = $1,503,787 )
2023	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	001	14	9/7/2023	NON-COMPETING CONTINUATION	$1,503,787
2023	2022	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	13	6/15/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,503,787

Issue Date FY: 2022 ( Subtotal = $1,511,193 )
2022	2022	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	004	13	8/30/2022	NON-COMPETING CONTINUATION	$1,511,193
2022	2021	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	002	12	1/5/2022	COMPETING CONTINUATION	$347,470
2022	2021	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	003	12	4/12/2022	COMPETING CONTINUATION	$0
2022	2021	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	12	10/13/2021	COMPETING CONTINUATION	$0
2022	2020	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	001	11	1/5/2022	NON-COMPETING CONTINUATION	-$347,470
														Subtotal = $1,511,193

Issue Date FY: 2021 ( Subtotal = $1,550,457 )
2021	2021	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	001	12	9/21/2021	COMPETING CONTINUATION	$1,550,457
2021	2020	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	11	6/10/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,550,457

Issue Date FY: 2020 ( Subtotal = $1,107,640 )
2020	2020	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	001	11	9/1/2020	NON-COMPETING CONTINUATION	$1,107,640
2020	2019	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	10	5/25/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,107,640

Issue Date FY: 2019 ( Subtotal = $1,083,735 )
2019	2019	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	001	10	8/27/2019	NON-COMPETING CONTINUATION	$1,083,735
2019	2018	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	9	7/12/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,083,735

Issue Date FY: 2018 ( Subtotal = $1,336,925 )
2018	2018	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	001	9	9/17/2018	SUPPLEMENT FOR EXPANSION	$104,015
2018	2018	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	9	8/20/2018	NON-COMPETING CONTINUATION	$1,232,910
														Subtotal = $1,336,925

Issue Date FY: 2017 ( Subtotal = $1,233,813 )
2017	2017	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	002	8	8/24/2017	NON-COMPETING CONTINUATION	$1,233,813
2017	2016	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	7	3/6/2017	COMPETING CONTINUATION	$89,023
2017	2015	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	001	6	3/6/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$89,023
														Subtotal = $1,233,813

Issue Date FY: 2016 ( Subtotal = $1,225,501 )
2016	2016	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	003	7	9/22/2016	COMPETING CONTINUATION	$1,225,501
2016	2015	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	001	6	5/13/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$558,241
2016	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	5	5/13/2016	NON-COMPETING CONTINUATION	-$558,241
2016	2015	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	372320011	DAVIDSON	USA	Cancer Centers Support Grants	002	6	9/19/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $1,225,501

Issue Date FY: 2015 ( Subtotal = $1,223,060 )
2015	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	5	8/18/2015	NON-COMPETING CONTINUATION	$1,223,060
														Subtotal = $1,223,060

Issue Date FY: 2014 ( Subtotal = $1,269,768 )
2014	2014	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	001	4	9/9/2014	NON-COMPETING CONTINUATION	$99,849
2014	2014	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	4	8/20/2014	NON-COMPETING CONTINUATION	$1,169,919
														Subtotal = $1,269,768

Issue Date FY: 2013 ( Subtotal = $800,339 )
2013	2013	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	3	8/21/2013	NON-COMPETING CONTINUATION	$800,339
														Subtotal = $800,339

Issue Date FY: 2012 ( Subtotal = $1,044,393 )
2012	2012	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	2	9/7/2012	NON-COMPETING CONTINUATION	$1,044,393
														Subtotal = $1,044,393

Issue Date FY: 2011 ( Subtotal = $1,066,141 )
2011	2011	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Centers Support Grants	000	1	9/23/2011	NEW	$1,066,141
														Subtotal = $1,066,141

Grand Total All Awards = $17,664,563

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Disparities in breast cancer treatment using Granulocyte colony-stimulating factors and CDK4/6 inhibitors between African and European ancestry individuals in two large Electronic Health Records

Award Number: U54CA163072

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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