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Cornell ME/CFS Collaborative Research Center

Award Number: U54AI178855
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2017
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Cornell ME/CFS Collaborative Research Center - Project Summary: Overall Despite the enormous suffering endured by millions of people worldwide, the underlying causes of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are unknown and effective therapies are lacking. ME/CFS is characterized by debilitating fatigue, musculoskeletal pain, headaches, cognitive difficulties orthostatic intolerance, and sleep disturbances. The absence of simple objective tests prevents many from obtaining an appropriate diagnosis and inhibits drug development because of the lack of biomarkers to monitor the efficacy of experimental therapies. In order to gain fundamental mechanistic insights into ME/CFS, we will leverage the experience, capabilities and varied backgrounds of researchers from four different colleges at Cornell University, Florida Atlantic University, the Hospital for Special Surgery, and an ME/CFS expert physician. We will take advantage of an enormous amount of data already obtained from patients and controls both before and after symptom provocation through exercise, as well as a valuable set of new samples. Three research projects will seek to (1) use cutting-edge multi-omic single cell profiling to examine alterations in cell types, gene expression, and cell-cell interactions that occur in ME/CFS muscle (Project 1), (2) identify tissue injured in ME/CFS following exercise through characterization of RNA released into circulation and (3) identify the RNA and protein cargo of extracellular vesicles in ME/CFS patients that may alter function of target cells (Project 2) and (4) Use genomic and computational methods to better understand the gene regulatory mechanisms that result in immune dysregulation in ME/CFS and systematically identify ME/CFS-specific alterations in signaling across the immune system (Project 3). These three research projects are supported by a Research Core that will act as a resource for genomics technology expertise, reagents, and services and for data management and integrated analysis. Multi-omic analysis and predictive modeling carried out in all three Projects will provide a foundation for future development of therapeutics and diagnostic tests. All Center activities will be coordinated through an Administrative Core, which will foster synergy and integration within the Center, while also being the platform for collaboration with other ME/CFS Collaborative Research Centers, a Patient/Advocate/Caregiver Committee, other ME/CFS researchers, and the Data Management Coordinating Center. The Administrative Core will also be responsible for outreach activities that are designed to increase awareness and understanding of ME/CFS within the research community, health professionals, and the general public, and will administer a pilot project program designed to bring new ideas and researchers into the ME/CFS field.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,883,800 )
2026	2026	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Allergy and Infectious Diseases Research	001	9	4/3/2026	NON-COMPETING CONTINUATION	$1,883,800
2026	2025	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Allergy and Infectious Diseases Research	000	8	3/10/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,883,800

Issue Date FY: 2025 ( Subtotal = $1,903,222 )
2025	2025	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Allergy and Infectious Diseases Research	001	8	7/23/2025	NON-COMPETING CONTINUATION	$1,903,222
2025	2024	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Allergy and Infectious Diseases Research	000	7	2/12/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,903,222

Issue Date FY: 2024 ( Subtotal = $1,866,110 )
2024	2024	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Allergy and Infectious Diseases Research	001	7	3/13/2024	NON-COMPETING CONTINUATION	$1,866,110
2024	2023	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Allergy and Infectious Diseases Research	000	6	12/27/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $1,866,110

Issue Date FY: 2023 ( Subtotal = $2,562,524 )
2023	2023	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Allergy and Infectious Diseases Research	001	6	8/22/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$666,130
2023	2023	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Allergy and Infectious Diseases Research	000	6	4/11/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,896,394
														Subtotal = $2,562,524

Grand Total All Awards = $8,215,656

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Cornell ME/CFS Collaborative Research Center

Award Number: U54AI178855

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2017

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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